Abal M, Andreu JM, Barasoain I (2003) Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action. Curr Cancer Drug Targets 3(3):193–203

Article  CAS  PubMed  Google Scholar 

Abd El-Aal SA, Abd Elrahman M, Reda AM et al (2022) Galangin mitigates DOX-induced cognitive impairment in rats: implication of NOX-1/Nrf-2/HMGB1/TLR4 and TNF-α/MAPKs/RIPK/MLKL/BDNF. Neurotoxicol 92:77–90.

Article  CAS  Google Scholar 

Abdelkarim M, Perez-Davalos L, Abdelkader Y et al (2023) Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles. Expert Opin Drug Deliv 20(1):13–30

Article  CAS  PubMed  Google Scholar 

Adekola KU, Dalva Aydemir S, Ma S, Zhou Z, Rosen ST, Shanmugam M (2015) Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin. Leuk Lymphoma 56(2):450–459

Article  CAS  PubMed  Google Scholar 

Akbar S, Subhan F, Shahid M, Wadood A et al (2020) 6-Methoxyflavanone abates cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: a behavioral and molecular simulation study. Eur J Pharmacol 872:172972

Article  CAS  PubMed  Google Scholar 

Alcindor T, Beauger N (2011) Oxaliplatin: a review in the era of molecularly targeted therapy. Curr Oncol 18(1):18–25

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alharbi I, Alharbi H, Almogbel Y et al (2020) Effect of metformin on doxorubicin-induced memory dysfunction. Brain sci 10(3):152

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alhowail AH, Bloemer J, Majrashi M et al (2019) Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation. Toxicol Mech Methods 29(6):457–466

Article  CAS  PubMed  Google Scholar 

Ali MA, Menze ET, Tadros MG, Tolba MF (2020) Caffeic acid phenethyl ester counteracts doxorubicin-induced chemobrain in Sprague-Dawley rats: emphasis on the modulation of oxidative stress and neuroinflammation. Neuropharmacol 181:108334

Article  CAS  Google Scholar 

Alrushaid S, Zhao Y, Sayre CL, Maayah ZH et al (2017) Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative. Drug Delivery Translational Res 7:582–597

Article  CAS  Google Scholar 

Alsikhan RS, Aldubayan MA, Almami IS, Alhowail AH (2023) Protective effect of galantamine against doxorubicin-induced neurotoxicity. Brain Sci 13(6):971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aluise CD, Miriyala S, Noel T, Sultana R et al (2011) 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain. Free Radical Biol Med 50(11):1630–1638

Article  CAS  Google Scholar 

Angelini A, Conti P, Ciofani G, Cuccurullo F, Di Ilio C (2013) Modulation of multidrug resistance P-glycoprotein activity by antiemetic compounds in human doxorubicin-resistant sarcoma cells (MES-SA/Dx-5): implications on cancer therapy. J Biol Regul Homeost Agents 27(4):1029–1037

CAS  PubMed  Google Scholar 

Argenziano M, Gigliotti CL, Clemente N, Boggio E, Ferrara B, Trotta F, Pizzimenti S, Barrera G et al (2020) Improvement in the Anti-tumor Efficacy of Doxorubicin Nanosponges in In Vitro and in mice bearing breast tumor models. Cancers 12(1):162. https://doi.org/10.3390/cancers12010162

Article  CAS  PubMed  PubMed Central  Google Scholar 

Argyriou AA, Kyritsis AP, Makatsoris T, Kalofonos HP (2014) Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature. Cancer Manag res 135–147

Armenian S, Bhatia S (2018) Predicting and preventing anthracycline-related cardiotoxicity. Am Soc Clin Oncol Educational Book 38:3–12

Article  PubMed  Google Scholar 

Arndt V, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A et al (2017) Quality of life in long-term and very long-term cancer survivors versus population controls in Germany. Acta Oncol 56(2):190–197

Article  PubMed  Google Scholar 

Ashley N, Poulton J (2009) Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs. Biochem biophysic res comm378(3), 450–455

Asma ST, Acaroz U, Imre K, Morar A, Shah SRA et al (2022) Natural products/bioactive compounds as a source of anticancer drugs. Cancers 14(24):6203

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aviello G, Knaus UG (2017) ROS in gastrointestinal inflammation: rescue or sabotage? Br J Pharmacol 174(12):1704–1718

Article  CAS  PubMed  Google Scholar 

Bagues A, López-Tofiño Y, Llorente-Berzal A, Abalo R (2022) Cannabinoid drugs against chemotherapy-induced adverse effects: focus on nausea/vomiting, peripheral neuropathy and chemofog in animal models. Behav Pharmacol 33(23):105–129

Article  PubMed  Google Scholar 

Bai RY, Staedtke V, Aprhys CM, Gallia GL, Riggins GJ (2011) Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neurooncology 13(9):974–982

CAS  Google Scholar 

Beji S, D’Agostino M, Gambini E, Sileno S et al (2021) Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells. BMC biol 19(1):124

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bientinesi E, Lulli M, Becatti M, Ristori S, Margheri F, Monti D (2022) Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: the role of Quercetin in modulating these processes. Mech Ageing Dev 206:111689

Article  CAS  PubMed  Google Scholar 

Bonavida B, Bharti AC, Aggarwal BB (2017) Role of nutraceuticals in cancer chemosensitization. Academic

Borai IH, Ezz MK, Rizk MZ, Aly HF et al (2017) Therapeutic impact of grape leaves polyphenols on certain biochemical and neurological markers in AlCl3-induced Alzheimer’s disease. Biomed Pharmaco 93:837–851

Article  CAS  Google Scholar 

Brüning A, Burger P, Vogel M, Rahmeh M, Gingelmaier A et al (2009) Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis. Cancer Biol Ther 8(3):226–232

Article  PubMed  Google Scholar 

Bulbake U, Doppalapudi S, Kommineni N, Khan W (2017) Liposomal formulations in clinical use: an updated review. Pharmaceutics 9(2):12

Article  PubMed  PubMed Central  Google Scholar 

Cardinale D, Iacopo F, Cipolla CM (2020) Cardiotoxicity of anthracyclines. Front Cardiovasc med 7:26

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cardoso CV, de Barros MP, Bachi ALL et al (2020) Chemobrain in rats: behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration. Behav Brain Res 378:112233

Article  CAS  PubMed  Google Scholar 

Cavalier AN, Clayton ZS, Hutton DA et al (2021) Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol 152:111451

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chahine N, Nader M, Duca L, Martiny L, Chahine R (2016) Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia-reperfusion in vitro. Drug Chem Toxicol 39(1):87–96

Article  CAS  PubMed  Google Scholar 

Chegaev K, Riganti C, Rolando B, Lazzarato L et al (2013) Doxorubicin-antioxidant co-drugs. Bioorg Med Chem Lett 23(19):5307–5310

Article  CAS  PubMed  Google Scholar 

Chen AM, Zhang M, Wei D, Stueber D, Taratula O, Minko T, He H (2009) Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug resistant cancer cells. Small 5(23):2673

Article  CAS  PubMed