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Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with a risk associated with hormonal and repr...
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity an...
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
The long-term symptoms of COVID-19 are the subject of public and scientific discussions. Understanding how those long COVI...
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
Massive evidence shows that intestinal tryptophan metabolites affected by intestinal flora can modulate the progression of...
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
Human Inborn Errors of Immunity (IEIs) encompass a clinically and genetically heterogeneous group of disorders, ranging fr...
Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis
Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis
Acute lung injury (ALI) is characterized by acute respiratory failure with tachypnea and widespread alveolar infiltrates, ...
FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1
FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1
Esophageal cancer (EC) is the 9th most frequently diagnosed malignancy globally with unfavorable prognosis. Immune escape ...
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in huma...
The immunosuppressive landscape in tumor microenvironment
The immunosuppressive landscape in tumor microenvironment
Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical ...
DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1β in vitro
DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1β in vitro
The pathological manifestation of the inflammatory process primarily stems from the heightened release of pro-inflammatory...
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis
Various lymphocyte subpopulations, including NK cells as well as γδ T cells, have been considered an important e...
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and car...
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial
The gut microbiome can modulate systemic inflammation and is therefore target for immunomodulation. Immunomodulating effec...
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response
Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe complication of sepsis characterized by acu...
Long non-coding RNA ENSMUST00000197208 promotes a shift in the Th17/Treg ratio via the P2X7R-NLRP3 inflammasome axis in collagen-induced arthritis
Long non-coding RNA ENSMUST00000197208 promotes a shift in the Th17/Treg ratio via the P2X7R-NLRP3 inflammasome axis in collagen-induced arthritis
Recently, long non‑coding RNAs (lncRNAs) have been implicated in several human diseases, including arthritis. Howeve...
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer
The ubiquitin–proteasome system (UPS) is an essential regulatory system for maintaining homeostasis, and its dysfunc...
Immune cells and hypertension
Immune cells and hypertension
Hypertension is one of the leading causes of death due to target organ injury from cardiovascular disease. Although there ...
Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor
Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor
Cite this articleKnoche, S.M., Larson, A.C., Brumfield, G.L. et al. Correction: Major histocompatibility complex class I m...
Fructus lycii oligosaccharide alleviates acute liver injury via PI3K/Akt/mTOR pathway
Fructus lycii oligosaccharide alleviates acute liver injury via PI3K/Akt/mTOR pathway
Regulating the immune-environment is essential for treating acute liver injury (ALI). However, the deficiency of an effect...
Comparative analyses of various IgE-mediated and non-IgE-mediated inducers of mast cell degranulation for in vitro study
Comparative analyses of various IgE-mediated and non-IgE-mediated inducers of mast cell degranulation for in vitro study
In vitro investigations of mast cell (MC) degranulation are essential for studying many diseases, particularly allergy and...
Impact of microparticles released during murine systemic inflammation on macrophage activity and reactive nitrogen species regulation
Impact of microparticles released during murine systemic inflammation on macrophage activity and reactive nitrogen species regulation
Microparticles (MPs) packaged with numerous bioactive molecules are essential vehicles in cellular communication in variou...
Insights into the immunological description of cryoglobulins with regard to detection and characterization in Slovenian rheumatological patients
Insights into the immunological description of cryoglobulins with regard to detection and characterization in Slovenian rheumatological patients
The detection of cryoglobulins (CG) used to diagnose cryoglobulinemic vasculitis requires strict adherence to protocol, wi...
Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy
Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy
Food allergy (FA) is a common immune disorder that involves dysfunctional immune regulation. More remedies for restoring i...
Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort
Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort
Autoantibodies are the hallmark of autoimmunity, and specifically, antinuclear antibodies (ANA) are one of the most releva...
Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study
Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study
Behçet disease (BD) is an autoimmune and autoinflammatory disease mainly affecting the Silk Road countries. The inter...
Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1
Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1
Allergic rhinitis (AR) is a common allergic disease with increasing prevalence globally. However, the molecular mechanism ...
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease
IL-39 (Interleukin-39) is a heterodimeric cytokine composed of IL-23p19 and EBI3 (Epstein-Barr virus-induced gene 3) subun...
Rational design of multi-epitope-based vaccine by exploring all dengue virus serotypes proteome: an immunoinformatic approach
Rational design of multi-epitope-based vaccine by exploring all dengue virus serotypes proteome: an immunoinformatic approach
Millions of people’s lives are being devastated by dengue virus (DENV), a severe tropical and subtropical illness sp...
Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study
Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study
TOB/BTG is a family of antiproliferative proteins that play an important role in the regulation of immune responses, actin...
Association study between killer immunoglobulin-like receptor polymorphisms and susceptibility to COVID-19 disease: a systematic review and meta-analysis
Association study between killer immunoglobulin-like receptor polymorphisms and susceptibility to COVID-19 disease: a systematic review and meta-analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a known virus that leads to a respiratory disease called c...
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