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Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
The inhibition of the neonatal Fc receptor (FcRn) is a promising therapeutic pathway in certain autoimmune disorders to re...
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury
After stroke, there is a high incidence of acute lung injury and impairment of intestinal barrier function. In this resear...
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis
Macrophages, the most abundant cells that participate in tumour progression, are the subject of a number of anticancer the...
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria
Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has con...
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
Lung adenocarcinoma (LUAD) is the common form of lung cancer and is prone to distant metastasis. IGF2BP2, an m6A modificat...
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Natural killer (NK) cells are a cytotoxic subset of innate lymphoid cells and have key roles in antitumoral immunity. This...
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review
Currently, COVID-19 is still striking after 4 years of prevalence, with millions of cases and thousands of fatali...
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype
Dendritic cells (DCs) are essential for promoting T lymphocyte responses since they are specialist antigen-presenting cell...
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Investigating the link between Helicobacter pylori infection and psoriatic disease: an immunological study
Helicobacter pylori (Hp) has been postulated as an infectious trigger of psoriatic disease, namely psoriasis (Ps) and psor...
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
This study assessed trends in age-standardized incidence (ASIR), prevalence (ASPR), and mortality rates (ASMR) per 100,000...
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord
Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding ...
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Psoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantl...
Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis
Exploring the landscape of congenital and idiopathic neutropenia in Moroccan children: a comprehensive retrospective analysis
Congenital neutropenia (CoN) is a heterogeneous group of inborn errors of immunity (IEI) characterized by recurrent infect...
The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning
The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning
Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy ...
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study
Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with a risk associated with hormonal and repr...
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity an...
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
The long-term symptoms of COVID-19 are the subject of public and scientific discussions. Understanding how those long COVI...
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
Massive evidence shows that intestinal tryptophan metabolites affected by intestinal flora can modulate the progression of...
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants
Human Inborn Errors of Immunity (IEIs) encompass a clinically and genetically heterogeneous group of disorders, ranging fr...
Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis
Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis
Acute lung injury (ALI) is characterized by acute respiratory failure with tachypnea and widespread alveolar infiltrates, ...
FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1
FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1
Esophageal cancer (EC) is the 9th most frequently diagnosed malignancy globally with unfavorable prognosis. Immune escape ...
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in huma...
The immunosuppressive landscape in tumor microenvironment
The immunosuppressive landscape in tumor microenvironment
Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical ...
DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1β in vitro
DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1β in vitro
The pathological manifestation of the inflammatory process primarily stems from the heightened release of pro-inflammatory...
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis
Various lymphocyte subpopulations, including NK cells as well as γδ T cells, have been considered an important e...
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and car...
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial
The gut microbiome can modulate systemic inflammation and is therefore target for immunomodulation. Immunomodulating effec...
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response
Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe complication of sepsis characterized by acu...
Long non-coding RNA ENSMUST00000197208 promotes a shift in the Th17/Treg ratio via the P2X7R-NLRP3 inflammasome axis in collagen-induced arthritis
Long non-coding RNA ENSMUST00000197208 promotes a shift in the Th17/Treg ratio via the P2X7R-NLRP3 inflammasome axis in collagen-induced arthritis
Recently, long non‑coding RNAs (lncRNAs) have been implicated in several human diseases, including arthritis. Howeve...
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer
The ubiquitin–proteasome system (UPS) is an essential regulatory system for maintaining homeostasis, and its dysfunc...
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