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Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis
Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis
Protein folding is a complex process in which amino acid sequences encode the information required for a polypeptide chain...
TRAIL (DR5) receptor and the modulation of TRAIL pathway in PLWHIV: key mechanisms in the progression of HIV disease
TRAIL (DR5) receptor and the modulation of TRAIL pathway in PLWHIV: key mechanisms in the progression of HIV disease
HIV infection is mainly described by depletion of CD4+ T-cells; however, this not only occurs in infected cells, also aris...
Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells
Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells
Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a ubiquitously expressed mitochondrial enzyme with a role in the de...
Sex alters thyroid hormone’s effect on protein O-GlcNAcylation in the aged mouse heart
Sex alters thyroid hormone’s effect on protein O-GlcNAcylation in the aged mouse heart
The aging heart undergoes physiological changes, many of which are sex dependent and encompass differential responses to c...
Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn’s disease-associated Escherichia coli
Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn’s disease-associated Escherichia coli
Adherent-invasive Escherichia coli (AIEC) is linked to intestinal inflammation in inflammatory bowel disease (IBD). Arthro...
Optimisation of cryopreservation conditions, including storage duration and revival methods, for the viability of human primary cells
Optimisation of cryopreservation conditions, including storage duration and revival methods, for the viability of human primary cells
Cryopreservation is a crucial procedure for safeguarding cells or other biological constructs, showcasing considerable pot...
Evaluation of antibacterial and anticancer properties of secondary metabolites isolated from soil Bacillus spp focusing on two strains of Bacillus licheniformis and Bacillus siamensis
Evaluation of antibacterial and anticancer properties of secondary metabolites isolated from soil Bacillus spp focusing on two strains of Bacillus licheniformis and Bacillus siamensis
Bacillus strains are well recognized for their inherent production of bioactive compounds that exhibit antibacterial and a...
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury
Retinal ischemia–reperfusion (IR) injury is a basic pathological procedure in clinic and associated with various isc...
Induction of chronic asthma up regulated the transcription of senile factors in male rats
Induction of chronic asthma up regulated the transcription of senile factors in male rats
The main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assa...
Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins
Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins
Malignant gliomas exhibit rapid tumor progression and resistance to treatment, leading to high lethality. One of the cause...
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the devel...
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodel...
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases...
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of p...
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hema...
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsib...
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα...
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore ...
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of ap...
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to...
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Patients with intellectual disabilities are shown to have a limited capacity for cooperation, communication,and other biol...
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to i...
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have sugge...
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in t...
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, an...
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progr...
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action...
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcr...
Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
Janus kinase 3 (JAK3) is a member of the JAK family of tyrosine kinase proteins involved in cytokine receptor-mediated int...
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2
DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demon...
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