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In Vitro and In Vivo Catabolite Profiles of Leuprorelin in Rat and the Effects of NADPH in Leuprorelin Catabolism
In Vitro and In Vivo Catabolite Profiles of Leuprorelin in Rat and the Effects of NADPH in Leuprorelin Catabolism
The catabolism of leuprorelin was studied in rat-derived hepatic and extrahepatic in vitro models and in vivo to compare t...
A Comprehensive Review on the Therapeutic Applications of Snake Venom Nerve Growth Factor
A Comprehensive Review on the Therapeutic Applications of Snake Venom Nerve Growth Factor
Nerve growth factor (NGF) is a neurotrophin which is primarily involved in the growth, maintenance, proliferation and surv...
Reading Between the Lines in the Barany Lab: Lessons on Written and Unwritten Science and Mathematics
Reading Between the Lines in the Barany Lab: Lessons on Written and Unwritten Science and Mathematics
I reflect on my childhood experiences in the Barany Lab and connect them to several findings and themes from my subsequent...
Cilengitide Derivatives Suppress TGF-β1-Induced Migration and Invasion in Afatinib-Resistant Non-small Cell Lung Cancer Cells
Cilengitide Derivatives Suppress TGF-β1-Induced Migration and Invasion in Afatinib-Resistant Non-small Cell Lung Cancer Cells
In previous studies, we discussed the effect of cilengitide, a cyclic Arg-Gly-Asp (RGD) peptide, and its derivatives on th...
Modeling and Characterization of Scorpion Venom and Investigation of Its Anticancer Properties
Modeling and Characterization of Scorpion Venom and Investigation of Its Anticancer Properties
Scorpion venom contains various proteins and amino acids, which can be used to develop effective anti-venom medications. B...
Modified SPPS Protocol for the Synthesis of Novel Antimicrobial Peptides
Modified SPPS Protocol for the Synthesis of Novel Antimicrobial Peptides
Solid phase peptide synthesis is a standard synthetic strategy for peptides at both academic and industry level. Due to th...
Anticancer Peptides: Unveiling the Next Frontier in Cancer Treatment
Anticancer Peptides: Unveiling the Next Frontier in Cancer Treatment
Cancer remains a leading cause of mortality worldwide, with traditional chemotherapy frequently limited by issues such as ...
Chromatographic Profiling, Functional and Antimicrobial Properties of Globulin and Albumin Hydrolysates from Seeds
Chromatographic Profiling, Functional and Antimicrobial Properties of Globulin and Albumin Hydrolysates from Seeds
Resistance of microbial strains to conventional antibiotics has led to a continuous search for efficient alternatives such...
Specific TRPM8-II Antigen Determinant Clusters as an Oral Vaccine Prevent Chronic Prostatitis/Chronic Pelvic Pain Syndrome through Induction of Immune Tolerance
Specific TRPM8-II Antigen Determinant Clusters as an Oral Vaccine Prevent Chronic Prostatitis/Chronic Pelvic Pain Syndrome through Induction of Immune Tolerance
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains a significant clinical challenge due to its unclear eti...
Elucidation and Prevention of an Unexpected Methylamine Byproduct Formed During Trifluoroacetic Acid-Mediated Side Chain Deprotection of Azido-Containing Peptides
Elucidation and Prevention of an Unexpected Methylamine Byproduct Formed During Trifluoroacetic Acid-Mediated Side Chain Deprotection of Azido-Containing Peptides
We found that a byproduct characterized by a difference of 12 mass units is formed during TFA-mediated cleavage of azide-c...
Development of a Peptide Inhibitor To Prevent Alpha-Synuclein Fibrillization in Parkinson’s Disease
Development of a Peptide Inhibitor To Prevent Alpha-Synuclein Fibrillization in Parkinson’s Disease
Parkinson’s disease (PD), the second most frequently occurring neurodegenerative disorder. Alpha-synuclein, the prin...
Biodistribution Studies of FITC Labelled DP1 and DP1 Encapsulated Coumarin-6 PLGA Nanoparticles in Murine Model
Biodistribution Studies of FITC Labelled DP1 and DP1 Encapsulated Coumarin-6 PLGA Nanoparticles in Murine Model
Antibacterial host defense peptides (HDPs) are naturally occurring peptides that combat multidrug-resistant infections eff...
Transepithelial Transport of Hemp Protein-Derived Bioactive Peptide Trp–Tyr–Thr (WYT) in Human Caco-2 Cell Monolayers
Transepithelial Transport of Hemp Protein-Derived Bioactive Peptide Trp–Tyr–Thr (WYT) in Human Caco-2 Cell Monolayers
To improve bioactive peptide absorption and bioavailability, in-depth understanding of their transport across the intestin...
Peptides Unplugged: Small Chains Tackling Big Challenges—One Life-Saving Sequence at a Time!
Peptides Unplugged: Small Chains Tackling Big Challenges—One Life-Saving Sequence at a Time!
Peptides have garnered significant attention in recent years as multifunctional and promising therapeutic agents due to th...
Health Potential of Glycomacropeptide: A Review Highlighting Isolation, Characterization Methods, Chemistry and Biological Activities
Health Potential of Glycomacropeptide: A Review Highlighting Isolation, Characterization Methods, Chemistry and Biological Activities
Glycomacropeptide (GMP), a bioactive glycophosphopeptide derived from milk. Diverse methodologies, from conventional to ad...
Abundance of Antimicrobial Peptides in Mesenchymal Stem Cells and Tissues: Variations Among Species
Abundance of Antimicrobial Peptides in Mesenchymal Stem Cells and Tissues: Variations Among Species
Antimicrobial peptides (AMPs) are essential components of the innate immune system in living organisms. They not only have...
Design and Evaluation of ATN-161 Analogues as Fusion Inhibitors Targeting Integrins in SARS-CoV-2
Design and Evaluation of ATN-161 Analogues as Fusion Inhibitors Targeting Integrins in SARS-CoV-2
The COVID-19 pandemic renewed global focus on the development of novel antiviral agents. Peptides, owing to their high spe...
Effects of a Bioactive Tripeptide on the Downregulation of Oxidative Stress and Inflammatory Markers in LPS-Induced Fibroblast Cells
Effects of a Bioactive Tripeptide on the Downregulation of Oxidative Stress and Inflammatory Markers in LPS-Induced Fibroblast Cells
Bioactive peptides, composed of short amino acid sequences, have gained attention for their ability to modulate inflammati...
Production of Active Single-Chain Insulin in : No PTM for Insulin Activation
Production of Active Single-Chain Insulin in : No PTM for Insulin Activation
Severe insulin deficiency in animals causes diabetes mellitus, which is characterized by chronic hyperglycemia. Insulin ha...
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
This review aims to elucidate the mechanisms employed by Host Defense Peptides (HDPs) in propagating their effector functi...
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
The successful synthesis of a peptide requires the synchronization of several processes, including the efficient execution...
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Bacteria produce antimicrobial compounds to compete for nutrients and space in particular habitat. Bacteria of the genus P...
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Despite significant advancements in peptide chemistry, the persistent occurrence of aspartimide formation during peptide s...
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
The lionfish, originally from the Indo-Pacific, has become established in the western Atlantic Ocean and the Caribbean Sea...
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
One of the problems of diabetic patients is the formation of ulcers in the lower areas, especially the legs, and the treat...
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
The antimicrobial activity of two peptides, Uy234 derived from the venom of the scorpion Urodacus yaschenkoi and a consens...
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Basal insulin therapy is conventionally achieved by one of two broad medicinal approaches that entail either protracted ab...
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
The melanocortin system has been implicated in regulating various physiological pathways including skin and hair pigmentat...
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. Natural compounds, such as...
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
The next-generation anti-tumor drug peptide CIGB-300, developed by the Center for Genetic Engineering and Biotechnology (C...
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