Ali SA, Alam M, Abbasi A, Undheim EA, Fry BG, Kalbacher H et al (2016) Structure-activity relationship of chlorotoxin-like peptides. Toxins 8(2):36
Article PubMed PubMed Central Google Scholar
Alikhani HK, Bidmeshkipour A, Zargan J (2020) Cytotoxic and apoptotic induction effects of the venom of Iranian scorpion (Odontobuthus Bidentatus) in the Hepatocellular carcinoma cell line (HepG2). Int J Pept Res Ther. 26:1–10
Andersen T, Auk-Emblem P, Dornish M (2015) 3D cell culture in alginate hydrogels. Microarrays 4(2):133–161
Article CAS PubMed PubMed Central Google Scholar
Azimian H, Dayyani M, Toossi MTB, Mahmoudi M (2018) Bax/Bcl-2 expression ratio in prediction of response to breast cancer radiotherapy. Iran J Basic Med Sci 21(3):325
PubMed PubMed Central Google Scholar
Chai J, Yang W, Gao Y, Guo R, Peng Q, Abdel-Rahman MA et al (2021) Antitumor effects of scorpion peptide Smp43 through mitochondrial dysfunction and membrane disruption on hepatocellular carcinoma. J Nat Prod 84(12):3147–3160
Article CAS PubMed Google Scholar
Collins AR (2004) The comet assay for DNA damage and repair. Mol Biotechnol 26(3):249
Article CAS PubMed Google Scholar
D’Suze G, Rosales A, Salazar V, Sevcik CJT (2010) Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line. 56(8):1497–1505
Deshane J, Garner CC (2003) Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. 278(6):4135–4144Sontheimer HJJobc
Díaz-García A, Ruiz-Fuentes JL, Rodríguez-Sánchez H, Castro JAF (2017) Rhopalurus Junceus scorpion venom induces apoptosis in the triple negative human breast cancer cell line MDA-MB-231. J Venom Res 8:9
PubMed PubMed Central Google Scholar
Ding AH, Nathan CF, Stuehr D (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 141(7):2407–2412
Article CAS PubMed Google Scholar
Ding J, Chua P-J, Bay B-H, Gopalakrishnakone P (2014) Scorpion venoms as a potential source of novel cancer therapeutic compounds. Experimental Biology Med 239(4):387–393
Duval K, Grover H, Han L-H, Mou Y, Pegoraro AF, Fredberg J et al (2017) Modeling physiological events in 2D vs. 3D cell culture. Physiology 32(4):266–277
Article CAS PubMed PubMed Central Google Scholar
Edmondson R, Broglie JJ, Adcock AF, Yang L (2014) Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay Drug Dev Technol 12(4):207–218
Article CAS PubMed PubMed Central Google Scholar
Ghosh S, Pulinilkunnil T, Yuen G, Kewalramani G, An D, Qi D et al (2005) Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Am J Physiol Heart Circ Physiol 289(2):H768–H76
Article CAS PubMed Google Scholar
Gomes A, Bhattacharjee P, Mishra R, Biswas AK, Dasgupta SC, Giri B et al (2010) Anticancer potential of animal venoms and toxins
Gupta SD, Gomes A, Debnath A, Saha A, Gomes AJC-bi (2010a) Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins. 183(2):293–303
Gupta SD, Gomes A, Debnath A, Saha A, Gomes A (2010b) Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins. Chemico-Biol Interact 183(2):293–303
Jäger H, Dreker T, Buck A, Giehl K, Gress T, Grissmer SJM (2004) Blockage of intermediate-conductance Ca2+-activated K + channels inhibit human pancreatic cancer cell growth in vitro. 65(3):630–638
Jiang X, Zheng D, Lin J (2004) Effects of nitric oxide on mitochondrial permeability transition and cytochrome C of human hepatocellular carcinoma cell lines. Zhongguo Yi Xue Ke Xue Yuan xue bao. Acta Academiae Medicinae Sinicae 26(5):519–523
Kapałczyńska M, Kolenda T, Przybyła W, Zajączkowska M, Teresiak A, Filas V et al (2018) 2D and 3D cell cultures–a comparison of different types of cancer cell cultures. Archives Med Science: AMS 14(4):910
Karikas G (2010) Anticancer and chemopreventing natural products: some biochemical and therapeutic aspects. J BUON 15(4):627–638
Keshavarz Alikhani H, Bidmeshkipour A, Zargan J (2020) Cytotoxic and apoptotic induction effects of the venom of Iranian scorpion (Odontobuthus Bidentatus) in the Hepatocellular carcinoma cell line (HepG2). Int J Pept Res Ther 26:2475–2484
Ketterer B (1988) Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat Research/Fundamental Mol Mech Mutagen 202(2):343–361
Khemili D, Laraba-Djebari F, Hammoudi-Triki D (2020) Involvement of toll-like receptor 4 in neutrophil-mediated inflammation, oxidative stress and tissue damage induced by scorpion venom. Inflammation 43(1):155–167
Article CAS PubMed Google Scholar
Klöck G, Frank H, Houben R, Zekorn T, Horcher A, Siebers U et al (1994) Production of purified alginates suitable for use in immunoisolated transplantation. 40(5):638–643
Kruger NJ (2009) The Bradford method for protein quantitation. The protein protocols handbook: Springer; pp. 17–24
Lee KY (2012) Mooney DJJPips. Alginate: Prop Biomedical Appl 37(1):106–126
Lourenco WR, Pezier A (2002) Taxonomic consideration of the genus Odontobuthus Vachon (Scorpiones, Buthidae), with description of a new species. Rev Suisse Zool 109(1):115–125
Lv D, Hu Z, Lu L, Lu H, Xu X (2017) Three–dimensional cell culture: a powerful tool in tumor research and drug discovery. Oncol Lett 14(6):6999–7010
PubMed PubMed Central Google Scholar
Masihipour B, Zare A, Navidpour S, Taghavi Moghadam A, Akbari A, Rabiei H (2009) Identification and purification of the three toxins from Odotobuthus Bidentatus, Lourenco and Pezier 2002, venom (scorpions, Buthidae). J Bio Sci 9:494–498
Morrison R, Schleicher SM, Sun Y, Niermann KJ, Kim S, Spratt DE et al (2011) Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis. Journal of oncology. 2011
Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1–2):55–63
Article CAS PubMed Google Scholar
Mouhat S, Jouirou B, Mosbah A, De Waard M, Sabatier J-M (2004) Diversity of folds in animal toxins acting on ion channels. Biochem J 378(3):717–726
Article CAS PubMed PubMed Central Google Scholar
Olivier C, Oliver L, Lalier L, Vallette FM (2021) Drug resistance in glioblastoma: the two faces of oxidative stress. Front Mol Biosci 7:468
Ortiz E, Gurrola GB, Schwartz EF, Possani LD (2015) Scorpion venom components as potential candidates for drug development. Toxicon 93:125–135
Article CAS PubMed Google Scholar
Övey I, Naziroğlu M (2015) Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels. Neuroscience 284:225–233
Repetto G, Del Peso A, Zurita JL (2008) Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc 3(7):1125
Article CAS PubMed Google Scholar
Salehi_Najafabadi Z, Goudarzi H, Sajadi M (2021) Evaluation of in vivo lethality and in vitro cytotoxic effect of Odontobuthus Bidentatus scorpion venom. Archives of Razi Institute
Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 25:192–205
Article CAS PubMed Google Scholar
Shapiro L, Cohen SJB (1997) Novel alginate sponges for cell culture and transplantation. 18(8):583–590
Shehzad A, Ravinayagam V, AlRumaih H, Aljafary M, Almohazey D, Almofty S et al (2019) Application of three-dimensional (3D) tumor cell culture systems and mechanism of drug resistance. Curr Pharm Design 25(34):3599–3607
Siegel RL, Miller KD, Jemal A (2019) Cancer statistics, 2019. Cancer J Clin 69(1):7–34
Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47(2):389–394
Article CAS PubMed Google Scholar
Snyder LR, Kirkland JJ, Glajch JL, Practical (2012) HPLC method development: Wiley
Stock AA, Manzoli V, De Toni T, Abreu MM, Poh Y-C, Ye L et al (2020) Conformal coating of stem cell-derived islets for β cell replacement in type 1 diabetes. Stem cell Rep 14(1):91–104
Sun J-Y, Zhao X, Illeperuma WR, Chaudhuri O, Oh KH, Mooney DJ et al (2012) Highly Stretchable Tough Hydrogels 489(7414):133–136
Comments (0)