Production of Active Single-Chain Insulin in : No PTM for Insulin Activation

Adams JP, Holder AL, Catchpole B (2014) Recombinant canine single chain insulin analogues: insulin receptor binding capacity and ability to stimulate glucose uptake. Vet J 202(3):436–442

Article  CAS  PubMed  Google Scholar 

An BC, Lee SS, Jung HS, Kim JY, Lee Y, Lee KW, Lee SY, Tripathi BN, Chung BY (2015) An additional cysteine in a typical 2-Cys Peroxiredoxin of Pseudomonas promotes functional switching between peroxidase and molecular chaperone. FEBS Lett 589(19 Pt B):2831–2840

Article  CAS  PubMed  Google Scholar 

An BC, Hong S, Park HJ, Kim B-K, Ahn JY, Ryu Y, An JH, Chung MJ (2019) Anti-Colorectal Cancer effects of Probiotic-Derived p8 protein. Genes (Basel) 10(8):624

Article  CAS  PubMed  Google Scholar 

Baeshen NA, Baeshen MN, Sheikh A, Bora RS, Ahmed MMM, Ramadan HA, Saini KS, Redwan EM (2014) Cell factories for insulin production. Microb Cell Fact 13(1):141

Article  PubMed  PubMed Central  Google Scholar 

Bekard IB, Dunstan DE (2009) Tyrosine autofluorescence as a measure of bovine insulin fibrillation. Biophys J 97(9):2521–2531

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bliss M (1982) The discovery of insulin, university of Chicago press. Chicago, 155

Brange J, Ribel U, Hansen JF, Dodson G, Hansen MT, Havelund S, Melberg SG, Norris F, Norris K, Snel L, Sorensen AR, Voigt HO (1988) Monomeric insulins obtained by protein engineering and their medical implications. Nature 333:679–682

Article  CAS  PubMed  Google Scholar 

Brange J, Owens DR, Kang S, Volund A (1990) Monomeric insulins and their experimental and clinical implications. Diabetes Care 13:923–954

Article  CAS  PubMed  Google Scholar 

Brange J, Dodson GG, Xiao B (1991) Designing insulin for diabetes therapy by protein engineering. Curr Opin Struct Biol 1:934–940

Article  CAS  Google Scholar 

Deng L, Yang P, Li C, Xie L, Lu W, Zhang Y, Liu M, Wang G (2022) Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue. Genes Dis 10(3):1101–1113

Article  PubMed  PubMed Central  Google Scholar 

Hilgenfeld R, Seipke G, Berchtold H, Owens DR (2014) The evolution of insulin glargine and its continuing contribution to diabetes care. Drugs 74(8):911–927

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34(6):1249–1257

Article  PubMed  PubMed Central  Google Scholar 

Hua Q-X, Mayer JP, Jia W, Zhang W, Weiss MA (2006) The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state. J Biol Chem 281(38):28131–281042

Article  CAS  PubMed  Google Scholar 

Hua QX, Nakagawa SH, Jia W, Huang K, Phillips NB, Hu SQ, Weiss MA (2008) Design of an active ultra-stable single-chain insulin analog: synthesis, structure, and therapeutic implications. J Biol Chem 283:14703–14716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jafari E, Gheysarzadeh A, Mahnam K, Shahmohammadi R, Ansari A, Bakhtyari H, Mofid MR (2018) In Silico interaction of insulin-like growth factor binding protein 3 with insulin-like growth factor 1. Res Pharm Sci 13(4):332–342

Article  PubMed  PubMed Central  Google Scholar 

Jelvehgari M, Zakeri-Milani P, Siahi-Shadbad MR, Loveymi BD, Nokhodchi A, Azari Z, Valizadeh H (2010) Development of pH-sensitive insulin nanoparticles using Eudragit L100-55 and Chitosan with different molecular weights. AAPS PharmSciTech 11(3):1237–1242

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joo JI, Kim DH, Yun JW (2010) Extract of Chaga mushroom (Inonotus obliquus) stimulates 3T3-L1 adipocyte differentiation. Phytother Res 24:1592–1599

Article  PubMed  Google Scholar 

Kahn CR (1985) The molecular mechanism of insulin action. Annu Rev Med 36:429–451

Article  CAS  PubMed  Google Scholar 

Kanatsuna N, Papadopoulos GK, Moustakas AK, Lenmark A (2012) Etiopathogenesis of insulin autoimmunity. Anat Res Int 2012:457546

PubMed  PubMed Central  Google Scholar 

Kjeldsen T, Andersen AS, Hubálek F, Johansson E, Kreiner FF, Schluckebier G, Kurtzhals P (2024) Molecular engineering of insulin for Recombinant expression in yeast. Trends Biotechnol 42(4):464–478

Article  CAS  PubMed  Google Scholar 

Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE-B, Goalstone ML, Draznin B (2001) Insulin-induced adipocyte differentiation. J Biol Chem 276:28430–28435

Article  CAS  PubMed  Google Scholar 

Kristensen C, Andersen AS, Hach M, Wiberg FC, Schaffer L, Kjeldsen T (1995a) A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor. Biochem J 305:981–986

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kristensen C, Andersen AS, Hach M, Wiberg FC, Schäffer L, Kjeldsen T (1995b) A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor. Biochem J 305(Pt 3):981–986

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurtzhals P, Schaffer L, Sorensen A, Kristensen C, Jonassen I, Schmid C, Trub T (2000) Correlations of receptor binding and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 49:999–1005

Article  CAS  PubMed  Google Scholar 

Lane MD, Reed BC, Clements PR (1981) Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. Prog Clin Biol Res 66:523–542

PubMed  Google Scholar 

Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW (2000) Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 408:483–488

Article  CAS  PubMed  Google Scholar 

Li S, Wang L, Chusuei CC, Suarez V (2015) Nontoxic carbon Dots potently inhibit human insulin fibrillation. Chem Mater 27(5):1764–1771

Article  CAS  Google Scholar 

Lovell SC, Davis IW, Arendall WB, De Bakker PI, Word JM, Prisant MG, Richardson JS, Richardson DC (2003) Structure validation by Cα geometry:phi,psi and Cbeta deviation. Proteins 50(3):437–450

Article  CAS  PubMed  Google Scholar 

Majid M, Masoud S, Tarlan A, Nafiseh V, Hossein HF, Morteza G (2020) Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis. Health Promot Perspect 10(2):98–115

Article  Google Scholar 

Mao R, Chen Y, Chi Z, Wang Y (2019) Insulin and its single-chain analogue. Appl Microbiol Biotechnol 103(21–22):8737–8751

Article  CAS  PubMed  Google Scholar 

Markussen J, Hougaard P, Ribel U, Sorrenson A, Sorrenson E (1987) Soluble, prolonged-acting insulin derivatives. II. Degree of Protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30. Protein Eng 1:215–223

Article  CAS  PubMed  Google Scholar 

Markussen J, Fiil N, Hansen MT, Norris K, Ammerer G, Thim L, Voigt HO (1990) DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin. US Patent 4916212

Mikiewicz D, Bierczyńska-Krzysik A, Sobolewska A, Stadnik D, Bogiel M, Pawłowska M, Wójtowicz-Krawiec A, Baran PA, Łukasiewicz N, Romanik-Chruścielewska A, Sokołowska I, Stadnik J, Borowicz P, Płucienniczak G, Płucienniczak A (2017) Soluble insulin analogs combining rapid- and long-acting hypoglycemic properties - From an efficient E. coli expression system to a pharmaceutical formulation. PLoS ONE 12(3):e0172600

Article  PubMed  PubMed Central 

Comments (0)

No login
gif