Deep insight into cytokine storm: from pathogenesis to treatment

Fajgenbaum, D. C. & June, C. H. Cytokine storm. N. Engl. J. Med. 383, 2255–2273 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, L. et al. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduct. Target. Ther. 6, 255 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flemming, A. Sleep deprivation whips up cytokine storm. Nat. Rev. Immunol. 24, 2 (2024).

Article  CAS  PubMed  Google Scholar 

Kang, H. et al. Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome. Cell. Mol. Immunol. 21, 689–706 (2024).

Article  CAS  PubMed  Google Scholar 

Alarabei, A. A. et al. Immunomodulating phytochemicals: an insight into their potential use in cytokine storm situations. Adv. Pharm. Bull. 14, 105–119 (2024).

PubMed  Google Scholar 

Lerro, S. J., Schmerer, F. & Rapalski, A. J. Unusually severe cases seen in an explosive epidemic of influenza and influenza-like syndrome. US Armed Forces Med. J. 9, 487–497 (1958).

CAS  Google Scholar 

Alegre, M. L. et al. Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone. J. Immunol. 146, 1184–1191 (1991).

Article  CAS  PubMed  Google Scholar 

McCarthy, P. L. Jr. et al. Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease. Blood 78, 1915–1918 (1991).

Article  CAS  PubMed  Google Scholar 

Hervé, P. et al. Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease. Blood 79, 3362–3368 (1992).

Article  PubMed  Google Scholar 

Ferrara, J. L., Abhyankar, S. & Gilliland, D. G. Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1. Transpl. Proc. 25, 1216–1217 (1993).

CAS  Google Scholar 

Karki, R. & Kanneganti, T. D. The ‘cytokine storm’: molecular mechanisms and therapeutic prospects. Trends Immunol. 42, 681–705 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baik, A. H. et al. Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies. Circ. Res. 128, 1780–1801 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou, T., Su, T. T., Mudianto, T. & Wang, J. Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies. J. Exp. Med. 217, e20200674 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, G., Wang, H. & Meftahpour, V. Overall review of curative impact and barriers of CAR-T cells in osteosarcoma. EXCLI J. 23, 364–383 (2024).

PubMed  PubMed Central  Google Scholar 

Jin, H., Li, M., Jeong, E., Castro-Martinez, F. & Zuker, C. S. A body-brain circuit that regulates body inflammatory responses. Nature 630, 695–703 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubin, T. S. et al. Perforin and CD107a testing is superior to NK cell function testing for screening patients for genetic HLH. Blood 129, 2993–2999 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fardet, L. et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 66, 2613–2620 (2014).

Article  PubMed  Google Scholar 

Minoia, F. et al. Development and initial validation of the MS score for diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann. Rheum. Dis. 78, 1357–1362 (2019).

Article  CAS  PubMed  Google Scholar 

Lin, Z., Zuo, J. & He, S. Surrogate cytokine agonists: promising agents against COVID-19. Signal Transduct. Target. Ther. 7, 150 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, H. et al. Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis. Cell Discov. 9, 103 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sousa, P. M. B. et al. Fatal myocarditis following COVID-19 mRNA immunization: a case report and differential diagnosis review. Vaccines 12, 194 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Kullberg, R. F. J., de Brabander, J., Boers, L. S., Bos, L. D. J. & Wiersinga, W. J. Reply to: microbial burden-associated cytokine storm may explain non-resolving ARDS in COVID-19 patients. Am. J. Respir. Crit. Care Med. 206, 1183–1184 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Gibson, B. H. Y. et al. Plasmin drives burn-induced systemic inflammatory response syndrome. JCI Insight 6, e154439 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Gentile, L. F. & Moldawer, L. L. HMGB1 as a therapeutic target for sepsis: it’s all in the timing! Expert Opin. Ther. Targets 18, 243–245 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dettmer-Monaco, V. et al. Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis. J. Allergy Clin. Immunol. 153, 243–255.e214 (2024).

Article  CAS  PubMed  Google Scholar 

Sato, A. et al. Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking. Leukemia 29, 145–156 (2015).

Article  CAS  PubMed  Google Scholar 

Zhu, C. et al. Rationally designed approaches to augment CAR-T therapy for solid tumor treatment. Bioact. Mater. 33, 377–395 (2024).

CAS  PubMed  Google Scholar 

Yang, S. et al. Neutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma. Nat. Commun. 15, 360 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian, J. et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol. 21, 893–903 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu, J. et al. Clinical characteristics of 54 medical staff with COVID-19: A retrospective study in a single center in Wuhan, China. J. Med. Virol. 92, 807–813 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, F. et al. The laboratory tests and host immunity of COVID-19 patients with different severity of illness. JCI insight 5, e137799 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Ning, Q. et al. The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication. Signal Transduct. Target. Ther. 7

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