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Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization
Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization
Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected proces...
Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach
Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach
Delirium is a severe and common complication among critically ill patients, particularly those with SARS-CoV-2 infection, ...
Associations of accelerated epigenetic aging with cancer and mortality risk in the USA
Associations of accelerated epigenetic aging with cancer and mortality risk in the USA
DNA methylation (DNAm) algorithms have been developed to assess biological aging and its association with cancer. Despite ...
Psychological predictors of gerascophobia among middle-aged and older adults: the role of health anxiety and body image satisfaction
Psychological predictors of gerascophobia among middle-aged and older adults: the role of health anxiety and body image satisfaction
Gerascophobia—the excessive fear of aging—is linked to health anxiety and negative body perceptions. While hea...
A proper combination of movement and stillness: the interaction effect of sleep duration and physical activity on longitudinal cognitive performance in Chinese middle-aged and older adults
A proper combination of movement and stillness: the interaction effect of sleep duration and physical activity on longitudinal cognitive performance in Chinese middle-aged and older adults
Previous studies have shown that both nighttime sleep duration (NSD) and physical activity (PA) are independently associat...
Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis
Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis
Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) have been linked to osteoporosis and osteoarthritis...
Design and test–retest reliability of a new test to assess motor competence in healthy older adults
Design and test–retest reliability of a new test to assess motor competence in healthy older adults
The objective of this study was to design and analyze the test–retest reliability of a test to assess holistic motor...
Alterations in mitochondria and cellular senescence in aged sEH null female kidneys
Alterations in mitochondria and cellular senescence in aged sEH null female kidneys
Age-related structural and functional deterioration of the kidneys is common among elderly individuals and contributes to ...
Cellular senescence—from solid organs to vascularized composite allotransplants
Cellular senescence—from solid organs to vascularized composite allotransplants
Vascularized composite allotransplantation (VCA) has emerged as a novel therapy approach to restore form and function in p...
Dual-channel mechanism of groove music fused with Tai Chi to improve cognitive-emotional abilities in older adults based on a coupled fNIRS-EMG analysis: a randomized controlled study
Dual-channel mechanism of groove music fused with Tai Chi to improve cognitive-emotional abilities in older adults based on a coupled fNIRS-EMG analysis: a randomized controlled study
This study aimed to investigate the dual-pathway mechanisms underlying cognitive-emotional integration in older adults thr...
Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis
Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis
Reduced peak oxygen uptake (V̇O₂peak) is a hallmark of heart failure (HF) and aging, but studies on V̇O...
Ultra-processed foods, biological ageing, and all-cause mortality risk: a prospective cohort study using 172,225 participants from UK Biobank
Ultra-processed foods, biological ageing, and all-cause mortality risk: a prospective cohort study using 172,225 participants from UK Biobank
Ultra-processed foods (UPF) are increasingly linked to negative health outcomes, including chronic diseases and mortality....
Task-specific dynamical entropy variations in EEG as a biomarker for Parkinson’s disease progression
Task-specific dynamical entropy variations in EEG as a biomarker for Parkinson’s disease progression
Uncovering the neuronal mechanisms un-derlying optimal behavioral performance is essential to understand how the brain dyn...
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults
Diet is widely considered essential in dementia, but its association with white matter lesions (WMLs) remains unclear. Thi...
Health-related quality of life trajectories and loss of independence among community-dwelling older adults
Health-related quality of life trajectories and loss of independence among community-dwelling older adults
Health-related quality of life (HRQOL) is a key determinant of loss of independence (LOI) among older adults. However, the...
A simple blood biomarker based on gene expression describes cardiovascular health-related biological age
A simple blood biomarker based on gene expression describes cardiovascular health-related biological age
The need to monitor the aging process as a risk factor for disease and mortality beyond chronological age (CA) has led to ...
Methylation array signals are predictive of chronological age without bisulfite conversion
Methylation array signals are predictive of chronological age without bisulfite conversion
DNA methylation data has been used to make “epigenetic clocks” which attempt to measure chronological and biol...
High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats
High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats
Aging is associated with metabolic decline in the brain, increasing susceptibility to neurodegenerative diseases. While ex...
Comparison of the acute effects of breaking up prolonged sitting time with single-task or a dual-task walking on cognitive function and cerebral blood flow in older adults: a randomized crossover trial
Comparison of the acute effects of breaking up prolonged sitting time with single-task or a dual-task walking on cognitive function and cerebral blood flow in older adults: a randomized crossover trial
This randomized cross-over study examined the acute effects of single-task or dual-task walking physical activity (PA) bre...
Treatment of age-related decreases in GTP levels restores endocytosis and autophagy
Treatment of age-related decreases in GTP levels restores endocytosis and autophagy
Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged o...
Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diver...
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
The prevalence of hypertension increases with age and is the leading modifiable risk factor for cognitive impairment and d...
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frai...
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty is considered a clinical entity associated with a high risk for adverse health outcomes. However, its cl...
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Frailty is a complex condition characterized by a decline in multiple physiological systems, compromising an individual...
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation ...
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