Associations of accelerated epigenetic aging with cancer and mortality risk in the USA

Van Herck Y, Feyaerts A, Alibhai S, Papamichael D, Decoster L, Lambrechts Y, et al. Is cancer biology different in older patients? Lancet Healthy Longev. 2021;2(10):e663–77. https://doi.org/10.1016/s2666-7568(21)00179-3.

Article  PubMed  Google Scholar 

Yousefi PD, Suderman M, Langdon R, Whitehurst O, Davey Smith G, Relton CL. DNA methylation-based predictors of health: applications and statistical considerations. Nat Rev Genet. 2022;23(6):369–83. https://doi.org/10.1038/s41576-022-00465-w.

Article  CAS  PubMed  Google Scholar 

Reale A, Tagliatesta S, Zardo G, Zampieri M. Counteracting aged DNA methylation states to combat ageing and age-related diseases. Mech Ageing Dev. 2022;206:111695. https://doi.org/10.1016/j.mad.2022.111695.

Article  CAS  PubMed  Google Scholar 

Kivimäki M, Frank P, Pentti J, Xu X, Vahtera J, Ervasti J, et al. Obesity and risk of diseases associated with hallmarks of cellular ageing: a multicohort study. Lancet Healthy Longev. 2024;5(7):e454–63. https://doi.org/10.1016/s2666-7568(24)00087-4.

Article  PubMed  Google Scholar 

Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115. https://doi.org/10.1186/gb-2013-14-10-r115.

Article  PubMed  PubMed Central  Google Scholar 

Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–67. https://doi.org/10.1016/j.molcel.2012.10.016.

Article  CAS  PubMed  Google Scholar 

Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573–91. https://doi.org/10.18632/aging.101414.

Article  PubMed  Google Scholar 

Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019;11(2):303–27. https://doi.org/10.18632/aging.101684.

Article  CAS  PubMed  Google Scholar 

Lin Q, Weidner CI, Costa IG, Marioni RE, Ferreira MR, Deary IJ, et al. DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy. Aging (Albany NY). 2016;8(2):394–401. https://doi.org/10.18632/aging.100908.

Article  CAS  PubMed  Google Scholar 

Zhang Q, Vallerga CL, Walker RM, Lin T, Henders AK, Montgomery GW, et al. Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Med. 2019;11(1):54. https://doi.org/10.1186/s13073-019-0667-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horvath S, Ritz BR. Increased epigenetic age and granulocyte counts in the blood of Parkinson’s disease patients. Aging (Albany NY). 2015;7(12):1130–42. https://doi.org/10.18632/aging.100859.

Article  CAS  PubMed  Google Scholar 

Li X, Zhang Y, Gào X, Holleczek B, Schöttker B, Brenner H. Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study. EBioMedicine. 2021;74:103686. https://doi.org/10.1016/j.ebiom.2021.103686.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Schöttker B, Holleczek B, Brenner H. Associations of DNA methylation algorithms of aging and cancer risk: results from a prospective cohort study. EBioMedicine. 2022;81:104083. https://doi.org/10.1016/j.ebiom.2022.104083.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui X, Sun S, Zhang H, Gong Y, Hao D, Xu Y, et al. Associations of DNA methylation algorithms of aging with cardiovascular disease and mortality risk among US older adults. J Am Heart Assoc. 2025;14(9):e040374. https://doi.org/10.1161/jaha.124.040374.

Article  PubMed  PubMed Central  Google Scholar 

Centers for Disease Control and Prevention (CDC). About the National Health and Nutrition Examination Survey. 2020. Available from: https://www.cdc.gov/nchs/nhanes/?CDC_AAref_Val=https://www.cdc.gov/nchs/nhanes/index.htm.

Centers for Disease Control and Prevention (CDC). NCHS Ethics Review Board (ERB) Approval. Available from: https://www.cdc.gov/nchs/nhanes/about/erb.html.

CDC/National Center for Health Statistics. NHANES 1999–2002 DNA methylation array and epigenetic biomarkers. 2024. Available from: https://wwwn.cdc.gov/nchs/nhanes/dnam/.

Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, et al. Epigenetic clock for skin and blood cells applied to hutchinson gilford progeria Syndrome and ex vivo studies. Aging (Albany NY). 2018;10(7):1758–75. https://doi.org/10.18632/aging.101508.

Article  CAS  PubMed  Google Scholar 

Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol. 2014;15(2):R24. https://doi.org/10.1186/gb-2014-15-2-r24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vidal-Bralo L, Lopez-Golan Y, Gonzalez A. simplified assay for epigenetic age estimation in whole blood of adults. Front Genet. 2016;7:126. https://doi.org/10.3389/fgene.2016.00126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu AT, Binder AM, Zhang J, Yan Q, Reiner AP, Cox SR, et al. DNA methylation GrimAge version 2. Aging (Albany NY). 2022;14(23):9484–549. https://doi.org/10.18632/aging.204434.

Article  CAS  PubMed  Google Scholar 

Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJ, Houts R, Huffman K. Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. Elife. 2020;9:e54870.

CAS  PubMed  PubMed Central  Google Scholar 

Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, et al. DNA methylation-based estimator of telomere length. Aging (Albany NY). 2019;11(16):5895–923. https://doi.org/10.18632/aging.102173.

Article  CAS  PubMed  Google Scholar 

Centers for Disease Control and Prevention (CDC). National Health and Nutrition Examination Survey-Medical Conditions (MCQ). 2004. Available from: https://wwwn.cdc.gov/Nchs/Data/Nhanes/Public/2001/DataFiles/MCQ_B.htm.

Centers for Disease Control and Prevention (CDC). 2019 Public-use linked mortality files. 2021. Available from: https://www.cdc.gov/nchs/data-linkage/mortality-public.htm.

Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012;13:86. https://doi.org/10.1186/1471-2105-13-86.

Article  PubMed  PubMed Central  Google Scholar 

Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81(3):11.

Google Scholar 

Duan R, Fu Q, Sun Y, Li Q. Epigenetic clock: a promising biomarker and practical tool in aging. Ageing Res Rev. 2022;81:101743. https://doi.org/10.1016/j.arr.2022.101743.

Article  CAS  PubMed  Google Scholar 

Oblak L, van der Zaag J, Higgins-Chen AT, Levine ME, Boks MP. A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration. Ageing Res Rev. 2021;69:101348. https://doi.org/10.1016/j.arr.2021.101348.

Article  CAS  PubMed  Google Scholar 

Chervova O, Panteleeva K, Chernysheva E, Widayati TA, Baronik ŽF, Hrbková N, et al. Breaking new ground on human health and well-being with epigenetic clocks: a systematic review and meta-analysis of epigenetic age acceleration associations. Ageing Res Rev. 2024;102:102552. https://doi.org/10.1016/j.arr.2024.102552.

Article  CAS  PubMed  Google Scholar 

Dugué PA, Bassett JK, Wong EM, Joo JE, Li S, Yu C, Schmidt DF, Makalic E, Doo NW, Buchanan DD, Hodge AM. Biological aging measures based on blood DNA methylation and risk of cancer: a prospective study. JNCI Cancer Spectrum. 2021;5(1):pkaa109.

PubMed  Google Scholar 

Wang C, Ni W, Yao Y, Just A, Heiss J, Wei Y, et al. DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: the NAS, and KORA F4. EBioMedicine. 2021;63:103151. https://doi.org/10.1016/j.ebiom.2020.103151.

Article  CAS 

Comments (0)

No login
gif