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Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling
Defining human MC phenotypes in nasal polyposis. To gain deeper insights into the developmental signals directing MC diff...
Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats
Research ArticleOncologyTherapeutics Open Access | 10.1172/JCI181305 Xinxia Zhu,1,2 Russe...
A vaccine against cytomegalovirus: how close are we?
Focusing on platforms that have advanced beyond phase I study, several vaccines have demonstrated varying degrees of prot...
TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa
Mast cells (MCs) are evolutionarily old immune cells, of which humans have 2 largely different types. One is a constituti...
Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium
Review Open Access | 10.1172/JCI183836 James P. Bridges,1,2 Eszter K. Vladar,2 Jonath...
Leptin signaling maintains autonomic stability during severe influenza infection in mice
Research LetterEndocrinologyInfectious disease Open Access | 10.1172/JCI182550 Andrés R. Muño...
Clonal hematopoiesis JAKs up plaque formation
Clonal hematopoiesis (CH) is a condition in which aged hematopoietic stem cells (HSCs) acquire somatic mutations commonly...
A conversation with Zhijian (James) Chen
Zhijian (James) Chen (University of Texas Southwestern and HHMI) has had a storied research career focused on the molecul...
Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma
Research ArticleGeneticsOncology Open Access | 10.1172/JCI182768 Yanni Zeng,1,2,3 Chun-Li...
T helper 2 cell–directed immunotherapy eliminates precancerous skin lesions
Research ArticleDermatologyOncology Open Access | 10.1172/JCI183274 Tomonori Oka,1 Sabrin...
Elevated microRNA-187 causes cardiac endothelial dysplasia to promote congenital heart disease through inhibition of NIPBL
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1/BTK axis
TREM2 expression is upregulated in monocytes/macrophages and is associated with disease severity in sepsis. Sepsis patien...
Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis
Patients with HTG-AP have high serum TGs, serum NEFAs, and worse clinical outcomes. Between August 2019 and November 2021...
APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer’s disease
Research ArticleAgingNeuroscience Open Access | 10.1172/JCI184656 Qiuyun Tian,1 Junjie Li...
Complement-producing maternal microchimeric cells override infection susceptibility in complement-deficient murine offspring
Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Department of Pe...
MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain
Research ArticleImmunologyOncology Open Access | 10.1172/JCI181895 Garry Dolton,1 Hannah ...
68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer
Clinical Research and Public HealthOncology Open Access | 10.1172/JCI185408 Haojun Chen,1,2 ...
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy
Research ArticleCardiology Open Access | 10.1172/JCI181630 Bryan Z. Wang,1 Margaretha A.J...
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice
Research ArticleVascular biology Open Access | 10.1172/JCI182939 Wenli Liu,1 Brian D. Har...
A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations
Research ArticleImmunologyNeuroscience Open Access | 10.1172/JCI177793 Claudia Cantoni,1 ...
Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice
Research ArticleTransplantation Open Access | 10.1172/JCI177460 Nana Talvard-Balland,1,2 ...
Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses
TCR activation induces VEGF-B expression and secretion in T cells. To assess the autocrine metabolic regulators for T cel...
LOXL2-induced PEAR1 Ser891 phosphorylation suppresses CD44 degradation and promotes triple-negative breast cancer metastasis
Sex as a biological variable. This study exclusively examined female human breast tissue microarrays and female mice, bec...
Decoding the decline: unveiling drivers of sarcopenia
Conserved across a majority of mammalian species, sarcopenia is the age-related loss of skeletal muscle mass and function...
Human genetics and epigenetics of alcohol use disorder
While the field of AUD genetics has made considerable progress, substantial gaps persist (similar to other psychiatric di...
Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics
Research ArticleAgingMuscle biology Open Access | 10.1172/JCI172890 Haiming L. Kerr,1,2 K...
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication
Research ArticleEndocrinology Open Access | 10.1172/JCI178303 Hui Wang,1 Shanshan Guo,1 ...
CDKL3 is a targetable regulator of cell cycle progression in cancers
Research ArticleCell biologyTherapeutics Open Access | 10.1172/JCI178428 Haijiao Zhang,1 ...
Peripheral gating of mechanosensation by glial diazepam binding inhibitor
Research ArticleNeuroscience Open Access | 10.1172/JCI176227 Xinmeng Li,1 Arthur Silveira...
It’s good to know what to BACE the specificity of your inhibitors on
A recent breakthrough in the treatment of the initial stages of Alzheimer’s disease (AD) is marked by the first approved ...
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