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The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic
Abstract Keith Reemtsma was a pioneer in xenotransplantation, the Honorary Founding President of the International Xenotra...
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival
Abstract Porcine islet xenotransplantation is a viable strategy to treat diabetes. Its translation has been limited by the...
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants
Abstract Background Islet xenotransplantation is a promising concept for beta-cell replacement therapy. Reporter genes for...
MRI monitoring of transplanted neonatal porcine islets labeled with polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles in a mouse model
MRI monitoring of transplanted neonatal porcine islets labeled with polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles in a mouse model
Abstract Islet transplantation is a potential treatment option for certain patients with type 1 diabetes; however, it stil...
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation
Abstract Background The supply of human organs available for transplantation remains grossly inadequate globally. Animal-t...
Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation
Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation
Early View LETTER TO THE EDITOR David K.C. Cooper, Corresponding Author ...
Genetically engineered pig kidney transplantation in a brain‐dead human subject
Genetically engineered pig kidney transplantation in a brain‐dead human subject
Abstract In September 2021, a kidney (with donor-specific thymic tissue) from an α1, 3-galactosyltransferase gene-kn...
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation
Abstract The initial clinical trials of pig solid organ xenotransplantation (XTx) are drawing closer and could begin in th...
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells
Abstract Background We demonstrated that neonatal porcine bone marrow-derived mesenchymal stem cell (npBM-MSCs) could impr...
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models
Abstract The transplantation of organs across species offers the potential to solve the shortage of human organs. While ac...
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons
Abstract Introduction Pigs deficient in three glycosyltransferase enzymes (triple-knockout [TKO] pigs, that is, not expres...
Updateon xenotransplantation for May/June 2021
Updateon xenotransplantation for May/June 2021
Corresponding Author Centre for Transplant & Renal Research, Westmead Insti...
Porcine‐derived medical therapies for SARS‐CoV‐2: Traversing Muslim bioethical concerns and assuring equity
Porcine‐derived medical therapies for SARS‐CoV‐2: Traversing Muslim bioethical concerns and assuring equity
Corresponding Author Initiative on Islam and Medicine, Brookfield, Wisconsin, U...
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation
Abstract Background Nephrotic syndrome is a common complication of pig-to-baboon kidney xenotransplantation (KXTx) that ad...
Sensitive detection systems for infectious agents in xenotransplantation*
Sensitive detection systems for infectious agents in xenotransplantation*
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganism...
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses
Abstract Background Islet transplantation with neonatal porcine islets (NPIs) is a promising treatment for type 1 diabetes...
Generation of glycans depleted decellularized porcine pericardium, using digestive enzymatic supplements and enzymatic mixtures for food industry
Generation of glycans depleted decellularized porcine pericardium, using digestive enzymatic supplements and enzymatic mixtures for food industry
Abstract Background Xenogeneic pericardium has been used largely for various applications in cardiovascular surgery. Never...
Semi‐automated digital quantification of cellular infiltrates for in vivo evaluation of transplanted islets of Langerhans encapsulated with bioactive materials
Semi‐automated digital quantification of cellular infiltrates for in vivo evaluation of transplanted islets of Langerhans encapsulated with bioactive materials
Abstract Background In the field of xenotransplantation, digital image analysis (DIA) is an asset to quantify heterogeneou...
Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture
Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture
Abstract Background Porcine islet xenotransplantation is a promising treatment for type 1 diabetes as an alternative to hu...
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation
Abstract The current evidence is that sensitization to a pig xenograft does not result in the development of antibodies th...
Incompatibility between recipient CD47 and donor SIRPα is not a key risk factor for thrombocytopenia or anemia following rat liver xenotransplantation in mice
Incompatibility between recipient CD47 and donor SIRPα is not a key risk factor for thrombocytopenia or anemia following rat liver xenotransplantation in mice
Abstract Liver xenotransplantation (LXT) is greatly impeded by severe thrombocytopenia, anemia, and coagulopathy. Hepatic ...
Xenotransplantation Literature Update January/February 2021
Xenotransplantation Literature Update January/February 2021
Corresponding Author Department of Surgery, Schulze Diabetes Institute, Univers...
High‐quality porcine islets isolated from aged miniature pigs
High‐quality porcine islets isolated from aged miniature pigs
Corresponding Author Islet Cell Transplantation Project, Diabetes Research Cent...
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice
Abstract Background Alginate-encapsulated islet xenografts have restored normoglycemia in diabetic animals for various per...
Specificity profile of αGal antibodies in αGalT KO mice as probed with comprehensive printed glycan array: Comparison with human anti‐Galili antibodies
Specificity profile of αGal antibodies in αGalT KO mice as probed with comprehensive printed glycan array: Comparison with human anti‐Galili antibodies
Abstract Background The α1,3-galactosyltransferase gene-knockout (GalT KO) mice are able to produce natural anti-&#x...
Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters
Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters
Abstract Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation...
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture
Abstract Background Necrostatin-1 (Nec-1) supplementation to tissue culture media on day 3 has recently been shown to augm...
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation
Abstract Background Neonatal porcine islets (NPIs) can restore glucose control in mice, pigs, and non-human primates, repr...
Deceased humans and living pigs as sources of kidneys for clinical transplantation—Can they be compared?
Deceased humans and living pigs as sources of kidneys for clinical transplantation—Can they be compared?
Volume 28, Issue 3 e12670 LETTER TO THE EDITOR Abhijit Jagdale, Xen...
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats
Abstract Background The human-to-rat hematopoietic stem cell transplantation (HSCT) model is rare, unlike its human-to-mou...
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