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Quantitative genotoxicity assessment of -nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination
Quantitative genotoxicity assessment of -nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination
The contamination of N-nitrosamines (N-NAs) in pharmaceuticals has raised global concerns, due to potential carcinogenic r...
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
The widespread use of pesticides is increasing the presence of environmental contaminants with potential impacts on biodiv...
Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene
Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene
Dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and UV irradiation in occupational and environmental settings p...
Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease
Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease
Glycogen synthase kinase-3 (GSK-3) is a critical serine/threonine kinase that plays a central role in regulating various c...
Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment
Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment
Cell Painting visualizes toxicity-induced morphological changes by staining cellular structures with fluorescent dyes. Cou...
Construction of testicular organoids and their applications in the field of toxicology
Construction of testicular organoids and their applications in the field of toxicology
The decline in male sperm quality significantly contributes to infertility among couples of reproductive age, threatening ...
The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease
The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease
Alzheimer’s disease (AD), a neurodegenerative “memory killer” demanding urgent global intervention, has ...
Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy
Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy
Phthalates (PAEs) are well-recognized endocrine-disrupting compounds. Despite their established status as such, the associ...
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by
Polygonum multiflorum (PM) has been reported to cause immune-mediated idiosyncratic liver injury. 2,3,5,4’-tetrahydr...
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells
Organophosphate esters (OPEs), commonly used as flame retardants and plasticizers, are ubiquitous environmental contaminan...
Revolutionizing toxicological risk assessment: integrative advances in new approach methodologies (NAMs) and precision toxicology
Revolutionizing toxicological risk assessment: integrative advances in new approach methodologies (NAMs) and precision toxicology
Traditional toxicological paradigms, reliant on animal testing and simplistic in vitro models, face significant limitation...
In vitro metabolic profiling and structure–metabolism relationships of substituted acetyl fentanyl-type new psychoactive substances
In vitro metabolic profiling and structure–metabolism relationships of substituted acetyl fentanyl-type new psychoactive substances
The abuse of fentanyl-type new psychoactive substances (F-NPS), which exhibit the four defining characteristics of new psy...
Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression
Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression
Cellular systems responsible for the formation and removal of reactive oxygen species (ROS), functioning within physiologi...
Immunomodulatory effects of the herbicide glyphosate following occupational exposure
Immunomodulatory effects of the herbicide glyphosate following occupational exposure
Glyphosate, a widely used herbicide, has raised concerns regarding its impact on human health and the environment due to i...
News and views: lysine sorbylation enters the expanding universe of posttranslational modifications
News and views: lysine sorbylation enters the expanding universe of posttranslational modifications
Opinion Letter to Sin et al (Science Advances, 2025), Sorbate induces lysine sorbylation through noncanonical activities o...
In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
Over the past decade, fentanyl-type new psychoactive substances (F-NPS) have emerged as the most representative synthetic ...
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
The tumorigenic dose 50 (TD50) is a widely used measure of carcinogenic potency which has historically been used to determ...
Re-thinking the link between exposure to mercury and blood pressure
Re-thinking the link between exposure to mercury and blood pressure
Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which is a significant c...
Elucidating the Phase I metabolism of psilocin in vitro
Elucidating the Phase I metabolism of psilocin in vitro
Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps rema...
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances...
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Snake envenomation presents a significant global health challenge, especially in rural areas of tropical and subtropical r...
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
The potential risk of chemicals to the human eye is assessed by adopted test guidelines (TGs) for regulatory purposes to e...
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.cig vapi...
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Testing for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious a...
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlo...
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
The kinetically-derived maximal dose (KMD) is defined as the maximum external dose at which kinetics are unchanged relativ...
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Little is known about the impact of environmental pollution on thyroid function in the non-occupationally exposed populati...
Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink
Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink
Femtosecond lasers represent a novel tool for tattoo removal as sources that can be operated at high power, potentially le...
Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases
Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases
Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic a...
Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary
Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary
Exposomics is a field that studies environmental exposures and their impact on human health. The MRM-IDA-EPI method, which...
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