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Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies

Cohesin maintains genome integrity through its ability to bind and link DNA molecules via a Structural Maintenance of Chro...

Dna Repair

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Transcription-coupled repair of crosslinking DNA damage

Impediments to faithful transcription must be resolved to ensure accurate gene expression and safeguard normal cellular fu...

Dna Repair

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"Yin-Yang" of PARP1 in genotoxic and inflammatory response

The poly(ADP-ribose) polymerase superfamily (PARP superfamily) comprises a group of enzymes with ADP-ribosyltransferase (A...

Dna Repair

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Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer

The innate immune sensing system plays a critical role in recognizing and responding to DNA damage, which is a key factor ...

Dna Repair

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DNA repair at the crossroads of tumor immunogenicity and cancer therapy: Harnessing innate and adaptive immune pathways for improved therapeutic outcomes

Immunotherapy has revolutionized cancer treatment, particularly with immune checkpoint inhibitors (ICIs), which harness th...

Dna Repair

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Harnessing R-loop dynamics: Challenging cancer therapy resistance

RNA:DNA hybrids are atypical nucleic acid structures that predominantly form during the transcription of RNA, resulting in...

Dna Repair

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FBH1 and the replication stress response: Implications for genome stability and cancer development

Dna Repair

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Base excision repair in human cancer: Emerging diagnostic and therapeutic target

BER is a highly conserved and major DNA repair mechanism [1], [2] which acts like an immune surveillance system for DNA, e...

Dna Repair

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From cooperation to conflicts – A complicated relationship between transcription and replication

Volume 152, August 2025, 103872Author links open overlay panel, Highlights•Transcription and DNA replication share the DNA...

Dna Repair

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Multiple functions of PARP1 in the repair of DNA double strand breaks

Poly ADP-ribose polymerase (PARP) proteins directly contribute to a wide range of essential cellular processes, including ...

Dna Repair

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Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres

Volume 152, August 2025, 103876Author links open overlay panel, AbstractDNA resection is a universal process in genome mai...

Dna Repair

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Cytosolic DNA and intracellular Ca2+: Maintaining genome stability during replication stress

Starting from a single fertilized egg, trillions of rounds of DNA replication must occur during development to generate th...

Dna Repair

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Corrigendum to “Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer” [DNA Repair 152 (2025) 103868]

Available online 5 August 2025, 103878Author links open overlay panelMin-Guk Cho a, Gaorav P. Gupta a b c d eShow moreReco...

Dna Repair

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Proofreading exonuclease activities of Polδ and Polε differentially contribute to the removal of chain-terminating nucleoside analogs

Chain-terminating nucleoside analogs (CTNAs) are incorporated into genome during replication by replicative polymerase del...

Dna Repair

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Contributions of DNA double strand break repair pathways to DNA crosslink repair

DNA crosslink-inducing drugs are widely used in clinical settings for treatment of solid tumors. Double strand breaks (DSB...

Dna Repair

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S-palmitoylation: An oily modification guardinggenome stability

Genomic stability is essential for the faithful preservation and error-free transmission of genetic information across gen...

Dna Repair

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DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies

Impaired genomic stability is a hallmark of many cancers, with the DNA damage response (DDR) mechanisms serving as critica...

Dna Repair

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Insight into meiotic DNA end resection: Mechanisms and regulation

Volume 153, September 2025, 103886Author links open overlay panel, , , AbstractMeiosis generates reproductive cells with a...

Dna Repair

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The B cell dilemma: Diversity or fidelity?

Volume 153, September 2025, 103888Author links open overlay panel, , AbstractThe ability of B lymphocytes to diversify imm...

Dna Repair

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Innate immune sensing and signaling: Co-opted for genome surveillance? Implications for tumorigenesis

Volume 153, September 2025, 103890Author links open overlay panel, AbstractInnate immune signaling is traditionally associ...

Dna Repair

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PrimPol-mediated repriming elicits gap-filling by template switching and promotes cellular tolerance to cidofovir