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Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
This review explores the pivotal role of the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP...
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Mammalian zinc ectopeptidases have significant functions in deactivating neurological and hormonal peptide signals on the ...
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Polyphenolic compounds are among the most widely researched compounds for various therapeutic applications. However, natur...
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LO...
Talabostat, fibroblast activation protein inhibitor, attenuates inflammation and fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive fibrosis, where activated fibroblasts ...
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Huntington’s disease (HD) is an inherited, autosomal, neurodegenerative ailment that affects the striatum of the bra...
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people ...
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorb...
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enha...
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the mortality rate of myocardial in...
Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
Piperine is an amide alkaloid responsible for producing the pungent smell that comes from black pepper. Piperine has been ...
Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
This study comprehensively explores the complexities of rheumatoid arthritis during pregnancy and its impact on offspring....
Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
Garcinia pedunculata, a tropical plant found abundantly in the north-east region of India, has been used by many tradition...
Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study
Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study
Owing to controversy information surrounds effect of glucocorticoids on the evolution of COVID-19, we evaluate the effects...
Acellular spinal cord scaffold containing quercetin-encapsulated nanoparticles plays an anti-inflammatory role in functional recovery from spinal cord injury in rats
Acellular spinal cord scaffold containing quercetin-encapsulated nanoparticles plays an anti-inflammatory role in functional recovery from spinal cord injury in rats
Inflammatory responses play a crucial role in the pathophysiology of spinal cord injury (SCI) and developing new approache...
Epi-revolution in rheumatology: the potential of histone deacetylase inhibitors for targeted rheumatoid arthritis intervention
Epi-revolution in rheumatology: the potential of histone deacetylase inhibitors for targeted rheumatoid arthritis intervention
Autoimmune diseases hold significant importance in the realm of medical research, prompting a thorough exploration of pote...
Launaea fragilis extract attenuated arthritis in rats through modulation of IL-1β, TNF-α, IL-6, NF-κB, COX-2, IL-4, and IL-10
Launaea fragilis extract attenuated arthritis in rats through modulation of IL-1β, TNF-α, IL-6, NF-κB, COX-2, IL-4, and IL-10
Launaea fragilis (Asso) Pau is a Cholistan desert medicinal plant. Launaea species are used as traditional remedies agains...
Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network
Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network
Micromeria biflora (M.B) Benth has proven anti-inflammatory efficacy, thereby, the goal of the current investigation was t...
Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Pulmonary fibrosis (PF) is the end stage of lung injury and chronic lung diseases that results in diminished lung function...
Ethanol extract of Ziziphus nummularia ameliorates formaldehyde-induced arthritis in rats by regulating oxidative stress biomarkers and haematological profile
Ethanol extract of Ziziphus nummularia ameliorates formaldehyde-induced arthritis in rats by regulating oxidative stress biomarkers and haematological profile
Rheumatoid arthritis is an autoimmune inflammatory disorder that mainly affects bone and cartilage architecture. The conti...
Arbutin attenuates CFA-induced arthritis by modulating expression levels of 5-LOX, NF‑κB, IL-17, PGE-2 and TNF-α
Arbutin attenuates CFA-induced arthritis by modulating expression levels of 5-LOX, NF‑κB, IL-17, PGE-2 and TNF-α
Arbutin, a naturally soluble glycosylated phenol has antioxidant, antimicrobial, antitumor and anti-inflammatory propertie...
Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis
Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis
Inflammatory bowel diseases (IBDs) are prevalent and debilitating diseases with limited clinical treatment strategies. Mes...
Novel combination of Olesoxime/Resveratrol-encapsulated exosomes to improve cognitive function by targeting amyloid β-induced Alzheimer’s disease: investigation on in vitro and in vivo model
Novel combination of Olesoxime/Resveratrol-encapsulated exosomes to improve cognitive function by targeting amyloid β-induced Alzheimer’s disease: investigation on in vitro and in vivo model
Alzheimer's disease (AD) is a fatal neurological illness that worsens with time. Preventing the aggregate formation of...
Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19
Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19
Small intestine damage caused by diclofenac is called diclofenac enteropathy. Berberine (BBR), a class of isoquinoline alk...
Natural agents as wound-healing promoters
Natural agents as wound-healing promoters
The management of acute and chronic wounds resulting from diverse injuries poses a significant challenge to clinical pract...
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite t...
Using aspirin to prevent and treat cancer
Using aspirin to prevent and treat cancer
This review will discuss evidence that aspirin possesses anticancer activity. Long-term observational retrospective studie...
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain wit...
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Hepatic schistosomiasis is a prevalent form of chronic liver disease that drastically affects human health. Nevertheless, ...
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients...
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