Potentiation of analgesic activity following the complexation of Sobral, Faria & Proença () leaf essential oil with β-cyclodextrin

Ahrar J, Nematullah Md, Rahman MA (2025) Insights into morphine: extraction, structural characterization, and pharmacological properties. LabMed Discovery. https://doi.org/10.1016/j.lmd.2025.100043

Article  Google Scholar 

Alves CCF, Oliveira JD, Estevam EBB, Xavier MN, Nicolella HD, Furtado RA, Tavares DC, Miranda MLD (2020) Antiproliferative activity of essential oils from three plants of the Brazilian cerrado: Campomanesia adamantium (myrtaceae), Protium ovatum (burseraceae) and Cardiopetalum calophyllum (annonaceae). Braz J Biol 80(2):290–294. https://doi.org/10.1590/1519-6984.192643

Article  PubMed  CAS  Google Scholar 

Antonelo FA, Rodrigues MS, Cruz LC, Pagnoncelli MG, Cunha MAAda, Bonatto SJR, Busso C, Wagner Júnior A, Montanher PF (2023) Bioactive compounds derived from Brazilian Myrtaceae species: chemical composition and antioxidant, antimicrobial and cytotoxic activities. Biocatal Agric Biotechnol. https://doi.org/10.1016/j.bcab.2023.102629

Article  Google Scholar 

Borges PP, Benvenutti L, Lana Schneider A, Franke Echterhoff MR, Gonçalves Lopes B, Siebert DA, Micke GA, Vitali L, Alberton MD, Quintão NLM, Santin JR, Daufenback Machado I (2024) Effects of Myrcia pubipetala Miq (Myrtaceae) extract on innate inflammatory response. Nat Prod Res 38(10):1771–1775. https://doi.org/10.1080/14786419.2023.2215904

Article  PubMed  CAS  Google Scholar 

Bunnell AA, Marshall EM, Estes SK, Deadmond MC, Loesgen S, Strother JA (2025) Embryonic zebrafish irritant-evoked hyperlocomotion (EZIH) as a high-throughput behavioral model for nociception. Behav Brain Res 485:115526. https://doi.org/10.1016/j.bbr.2025.115526

Article  PubMed  Google Scholar 

Cheng H, Liang M, Dai S, Lu X, Huang Q, Lai F, Ma L, Li W, Liu X (2023) Oxidation characteristics and hazardous of α-pinene, β-pinene and turpentine. Arab J Chem 16(12):105322. https://doi.org/10.1016/J.ARABJC.2023.105322

Article  CAS  Google Scholar 

Costa WK, da Cruz RCD, da Silva Carvalho K, de Souza IA, dos Santos Correia MT, de Oliveira AM, da Silva MV (2024) Insecticidal activity of essential oil from leaves of Eugenia stipitata McVaugh against Aedes aegypti. Parasitol Int. https://doi.org/10.1016/j.parint.2023.102820

Article  PubMed  Google Scholar 

Costa WK, de Oliveira JRS, de Oliveira AM, da Santos IBS, da Cunha RX, de Freitas AFS, da Silva JWLM, de Silva VBG, de Aguiar JCROF, da Silva AG, do Navarro DMAF, de Lima VLM, da Silva MV (2020). Essential oil from Eugenia stipitata McVaugh leaves has antinociceptive, anti-inflammatory and antipyretic activities without showing toxicity in mice. In. Crops Prod. https://doi.org/10.1016/j.indcrop.2019.112059

Dahiya M, Kumar A, Yadav M, Chauhan S (2025) β-pinene ameliorates ICV-STZ induced Alzheimer’s pathology via antioxidant, anticholinesterase, and mitochondrial protective effects: in-silico and in-vivo studies. Eur J Pharmacol 991:177307. https://doi.org/10.1016/J.EJPHAR.2025.177307

Article  PubMed  CAS  Google Scholar 

Daviaud C, Ferraz CAA, e Silva MG, de Alencar Filho EB, Evangelista Mendes de Lima SY, Dumontet V, Júnior LJQ, da Silva Almeida JRG, Picot L, Baranger K, de Oliveira Júnior RG, Grougnet R (2025) Polymethoxyflavones from Gardenia oudiepe and semi-synthetic derivatives reduce nociception in mice: Evidence for the involvement of the MAPK pathway. Biomed Pharmacother. https://doi.org/10.1016/j.biopha.2024.117742

de Jesus ENS, Tavares MS, Barros PAC, Miller DC, da Silva PIC, Freitas JJS, de Lima AB, Setzer WN, da Silva JKR, Figueiredo PLB (2023) Chemical composition, antinociceptive and anti-inflammatory activities of the curzerene type essential oil of Eugenia uniflora from Brazil. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2023.116859

Article  PubMed  Google Scholar 

de Melo Candeia GLO, Costa WK, de Oliveira AM, Napoleão TH, Guedes Paiva PM, Ferreira MRA, Lira Soares LA (2022) Anti-inflammatory, antinociceptive effects and involvement of opioid receptors in the antinociceptive activity of Eugenia uniflora leaves obtained with water, ethanol, and propylene glycol mixture. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2022.115508

de Souza Sampaio R, Petícia do Nascimento E, Alencar de Menezes IR, dos Sales, VS, Brito Pereira, AO, Mendes de Lacerda G, Santos ES, Pereira Lopes MJ, Gomes da Silva L, de Araújo Delmondes G, Vieira, NB, Zaia, VM, Bezerra DS, Martins da Costa, JG, Bezerra Felipe CF, Kerntopf MR (2020). Antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil in mice. Food and Chemical Toxicology, 135. https://doi.org/10.1016/j.fct.2019.111053

de Veras BO, Dos Santos YQ, Oliveira FG, Almeida JR, da Silva AG, Correia MT, Diniz KM, de Oliveira JR, Lima VL, Navarro DM, de Aguiar JC (2019) Algrizea minor sobral, faria and proença (Myrteae, Myrtaceae): composição química, atividade antinociceptiva, antimicrobiana e antioxidante do óleo essencial. Pesquisa de Produtos Naturais 34(20): 3013–3017. https://doi.org/10.1080/14786419.2019.1602832

de Veras BO, de Medeiros Moura GM, de Barros AV, da Silva MV, de Assis PAC, de Oliveira Farias JCR, Navarro DMDAF, Ximenes RM, Wanderley AG, de Oliveira MBM, de Sousa Lopes AC (2023) Antinociceptive and anti-inflammatory activities of essential oil of the leaves of Amburana cearensis (Allemão) AC Smith. from the semi-arid region of Northeastern Brazil. J Ethnopharmacol 317:116858. https://doi.org/10.1016/j.jep.2023.116858

Dewi IP, Dachriyanus Aldi Y, Ismail NH, Osman CP, Putra PP, Wahyuni FS (2025) A new xanthone from Garcinia cowa Roxb. and its anti-inflammatory activity. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2025.119380

Article  PubMed  Google Scholar 

Duan Y, Deng J, Wang L, Yang Z, Zhao H, Xie Q, Nie Y (2025) Improvement of essential oil yield in the pyrolysis oil of Cinnamomum camphora leaves using a microwave-assisted segment heating method: product analysis, mechanism and kinetic model. J Anal Appl Pyrolysis. https://doi.org/10.1016/j.jaap.2025.107065

Article  Google Scholar 

Felipe CFB, Albuquerque AMS, de Pontes JLX, de Melo JÍV, Rodrigues TCML, de Sousa AMP, Monteiro ÁB, Ribeiro AEDS, Lopes JP, de Menezes IRA, de Almeida RN (2019) Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice. Fundam Clin Pharmacol 33(2):181–190. https://doi.org/10.1111/fcp.12416

Article  PubMed  CAS  Google Scholar 

Fernandes PHE, dos Alves CSC, da Almeida JRGS, de Veras BO, da Silva MV (2024) Development of a gastroprotector from Algrizea minor essential oil complexed with β-Cyclodextrin. J Drug Deliv Sci Technol. https://doi.org/10.1016/j.jddst.2024.105505

Froz MJdaL, Barros LdeSP, de Jesus ENS, Tavares MS, Mourão RHV, Silva RC, de Lima AB, da Silva PIC, Freitas JJS, Setzer WN, da Silva JKR, Negrão JNC, Figueiredo PLB (2024) Lippia alba essential oil: a powerful and valuable antinociceptive and anti-inflammatory medicinal plant from Brazil. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2024.118459

Article  PubMed  Google Scholar 

Gélinas C, Shahiri T S, Wang HT, Gallani MC, Oulehri W, Laporta D, Richebé P (2025) Validation of the nociception level index for the detection of nociception and pain in critically ill adults: protocol for an observational study. JMIR Res Protoc 14:e60672. https://doi.org/10.2196/60672

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Pu J, Yang Z, Zhang S, Zhang Z, Lu Q, Song D, Li X, Fang Z, Liu Y, Hu B (2024) Development of a Syzygium aromaticum, L. essential oil/hydroxypropyl-β-cyclodextrin inclusion complex: preparation, characterization, and evaluation. Ind Crops Prod. https://doi.org/10.1016/j.indcrop.2024.118500

Article  Google Scholar 

Ibrahim IA, Al-Qadhi HI (2025) The anti ulcerogenic effect of sildenafil and moringa on ulcers in rats. Tissue Cell. https://doi.org/10.1016/j.tice.2024.102685

Article  PubMed  Google Scholar 

Iqbal U, Malik A, Sial NT, Mehmood MH, Uttra AM, Tulain UR, Erum A, Fayyaz-ur-Rehman M, Welson NN, Mahmoud MH, Alexiou A, Papadakis M, El-Saber Bathia G (2025) Eucalyptol attenuates indomethacin-induced gastric ulcers in rats by modulating the ICAM-1, eNOS and COX/LOX pathways: insights from in silico, in vitro and in vivo approaches. Food Chem Toxicol. https://doi.org/10.1016/j.fct.2025.115319

Article  PubMed  Google Scholar 

Norton SA, Blaydon LM, Niehaus M, Miller AP, Hill PL, Oltmanns TF, Bogdan R (2024) Inflammation is associated with pain and fatigue in older adults. Brain Behav Immunity Health 42:100874. https://doi.org/10.1016/j.bbih.2024.100874

Article  CAS  Google Scholar 

Proença CEB, Lughadha EMN, Lucas EJ, Woodgyer EM (2006) Algrizea (Myrteae, Myrtaceae): a new genus from the highlands of Brazil. Syst Bot 31(2):320–326. https://doi.org/10.1600/036364406777585874

Article  Google Scholar 

Radulović NS, Randjelović PJ, Stojanović NM, Cakić ND, Bogdanović GA, Živanović AV (2015) Aboriginal bush foods: a major phloroglucinol from Crimson Bottlebrush flowers (Callistemon citrinus, Myrtaceae) displays strong antinociceptive and anti-inflammatory activity. Food Res Int 77:280–289. https://doi.org/10.1016/j.foodres.2015.02.023

Article  CAS  Google Scholar 

Saleem BAA, Mohammed SA, Al-Taee AT (2025) Non-extractive spectrophotometric estimation of indomethacin in pharmaceuticals and biological fluids via ion-pair complexes. J Indian Chem Soc. https://doi.org/10.1016/j.jics.2024.101532

Article  Google Scholar 

Santos ES, de Sousa Machado ST, Rodrigues FB, da Silva YA, Matias LCX, Lopes MJP, Gomes ADS, Ribeiro TF, de Oliveira Garcia FA, Coutinho HDM, Felipe CFB, de Araújo Neves S, Kerntopf MR (2023) Potential anti-inflammatory, hypoglycemic, and hypolipidemic activities of alpha-pinene in diabetic rats. Process Biochem 126:80–86. https://doi.org/10.1016/J.PROCBIO.2022.12.023

Article  CAS  Google Scholar 

Shams SS, Shahi M, Azarakhshi F (2025) Theoretical insights into the interaction of 6-thioguanine anticancer drug with β-cyclodextrin as a pharmaceutical nanocarrier via density functional theory. Results Chem. https://doi.org/10.1016/j.rechem.2025.102159

Article  Google Scholar 

Sharma N, Sharma A, Lee HJ (2025) Direct fluorescence quenching based detection of indomethacin drug in biological fluids using carbon dots derived from waste Myrica esculenta seeds. J Environ Chem Eng. https://doi.org/10.1016/j.jece.2025.115745

Article  Google Scholar 

Silva VBG, da Fonsêca BMB, de Oliveira Farias JCR, Navarro DMDAF, de Oliveira AM, Napoleão TH, dos Santos Correia MT, de Menezes Lima VL, Costa WK, da Silva MV (2023) Chemical composition, antinociceptive and anti-inflammatory effects in mice of the essential oil of Psidium cattleyanum Sabine leaves. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2023.116443

Sobral M, Faria JEQ Jr., Proença CEB (2010) A new species of Algrizea (Myrteae, Myrtaceae) from Bahia, Brazil. Neodiversity 5(1): 1–6. https://doi.org/10.13102/neod.51.1

Souza MA, Kunh K, Sanaiotto O, Provinelli AC, Barufke M, Schindler MSZ, Mazon SC, Oliveira JV, Brusco I, Scapinello J, Magro JD, Müller LG (2024) Anti-inflammatory and antinociceptive effects of Aloysia gratissima leaves essential oil: an in vivo study. J Tradit Complement Med. https://doi.org/10.1016/j.jtcme.2024.10.002

Article  Google Scholar 

Wang X, Cui H, Wang W, Zhao Q, You J, Li X, Ma Y, Wang L (2025) Utilizing Litsea cubeba essential oil as a natural solution to combat Citrobacter freundii infections in turbot. Aquaculture 603:742416. https://doi.org/10.1016/j.aquaculture.2025.742416

Article  CAS  Google Scholar 

Yang J, Kok CR, Ciftci D, Hutkins R, Ciftci ON (2025) Hollow solid lipid particles loaded with essential oils via supercritical carbon dioxide to develop novel antimicrobial lipids with controlled release for food applications. Innovat Food Sci Emerg Technol. https://doi.org/10.1016/j.ifset.2025.103980

Article  Google Scholar 

Zamyad M, Abbasnejad M, Esmaeili-Mahani S, Mostafavi A, Sheibani V (2019) The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats. Arq Neuropsiquiatr 77(2):106–114.

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