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The m6A demethylase FTO controls Th1 differentiation and immunity against infections

CD4+ T cells represent a critical component of the adaptive immune system and are essential for defense against viral, fun...

Molecular Immunology

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Total free lipids from MDR strain of Mycobacterium tuberculosis “M” reduce T cell activation and CTL activity in healthy individuals

Tuberculosis (TB) continues to be the leading cause of death worldwide from a single infectious agent, with an estimated 7...

Molecular Immunology

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Clinical characteristics and outcomes of pediatric anterior and intermediate uveitis in China

Pediatric uveitis is relatively uncommon, representing 5–16 % of all uveitis cases in most tertiary care centers worldwide...

Molecular Immunology

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TSPAN15 enhances EMT-mediated metastasis of HCC by promoting autophagy through BTRC-mediated PDCD4 degradation

According to the World Health Organization, it is estimated that more than 1 million patients will die of hepatocellular c...

Molecular Immunology

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NLRP3 regulates macrophage function by M-CSF/M-CSFR signaling in acute radiation-induced lung injury

Radiation-induced lung injury (RILI) is the most common and major complication of chest radiotherapy, including radiation ...

Molecular Immunology

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LncRNA SNHG12 promotes EMT and metastasis of colorectal cancer via regulating TGF-β/Smad2/3 signaling pathway

ObjectiveIn this study, we aimed to explore the molecular mechanism of SNHG12 promoting colorectal cancer (CRC) progressio...

Molecular Immunology

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Helicobacter pylori delays neutrophil apoptosis but also drives the formation of cells with a leaky plasma membrane: Implications for inflammation

Opisthorchis viverrini (OV) infection is a major public health problem in South East Asia and is endemic in the Lower Meko...

Molecular Immunology

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Indications of trained innate immunity by Escherichia coli vaccination or chitin feed supplementation assessed during Ascaridia galli infection in chickens

Infections with the gastrointestinal roundworm Ascaridia galli, cause health problems and economic losses in laying hen hu...

Molecular Immunology

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Comparative transcriptomic analyses of macrophages infected with Toxoplasma gondii strains of different virulence provide molecular insights into the response of macrophage in phagocytosis and polarization to infection

Macrophages are essential for the proliferation and spread of Toxoplasma gondii. Modulating macrophage activation to impro...

Molecular Immunology

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Differences in complement activation of serum-resistant and serum-sensitive Klebsiella pneumoniae isolates

The genetically heterogeneous opportunistic gram-negative bacteria Klebsiella pneumoniae are a common cause of sepsis and ...

Molecular Immunology

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Using novel approaches to conjugate peptides of Macrotermes bellicosus and Curcuma longa for targeted intervention of irritable bowl diseases caused by tumor necrosis factor superfamily member 15 (TNFSF15)

Irritable Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, remains a challenging condition linked...

Molecular Immunology

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Proteome-wide reverse vaccinology to identify potential vaccine candidates against Staphylococcus aureus

Staphylococcus aureus (S. aureus), a Gram-positive facultative anaerobic bacterium, has the potential to become a highly v...

Molecular Immunology

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Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), constitutes a range of ch...

Molecular Immunology

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SAA1 deletion ameliorates cardiac injury after myocardial infarction by promoting macrophage transformation to reparative subtype

Among the various factors leading to fatalities from cardiovascular diseases, acute myocardial infarction (AMI) stands as ...

Molecular Immunology

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CRISPR-Cas9 engineering of human T regulatory cells – Design and optimization of a manufacturing process

Regulatory T cells (Tregs) are a subset of CD4 + T cells that comprise 5–10 % of the total CD4 + T cell population. Tregs,...

Molecular Immunology

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Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma

Psoralidin is a major component of the traditional Chinese medicine Psoraleae Fructus, which is derived from the dried mat...

Molecular Immunology

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NSUN3-mediated m5C modification of TAK1 promotes sepsis-induced pulmonary injury through regulating inflammation

Sepsis-induced pulmonary injury (SPI), also referred to as sepsis-associated acute lung injury (ALI), is a severe complica...

Molecular Immunology

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Trogocytosis-mediated acquisition of MHC class II molecules from plasmacytoid dendritic cells confers donor-specific immune tolerance to CD8+CD45RClow/- regulatory T cells

Extensive evidence supports the pivotal role of CD8+Tregs in transplantation and immunological disorders (Yao et al., 2017...

Molecular Immunology

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DNA vaccination combined with immune checkpoint inhibition eradicates tumors, inducing life-long immunity against breast cancer in mice

Allan Noé Domínguez-Romero: Visualization, Methodology, Formal analysis, Data curation, Conceptualization. Karen Manoutcha...

Molecular Immunology

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Klotho promotes bone formation in rheumatoid arthritis-associated osteoporosis by modulating the Fgf23/Fgfr1/NF-κB pathway and inhibiting ferroptosis

AimsRheumatoid arthritis (RA) frequently leads to osteoporosis (OP) and increased fracture risk. The protein Klotho plays ...

Molecular Immunology

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The role of post-translational modifications of cGAS in γδ T cells