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Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples
Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples
The HumanMethylationEPIC v2.0 BeadChip (EPIC v2.0) microarray is a widely used tool for genome-wide DNA methylation (DNAm)...
Organotypic Culture of Adult Vascularized Porcine Retina Explants In Vitro on Nanotube Scaffolds
Organotypic Culture of Adult Vascularized Porcine Retina Explants In Vitro on Nanotube Scaffolds
Organotypic long-term cultivation of vascularized retina explants is a major challenge for application in drug development...
SOCS3: An Immunological Biomarker Offering Potential Therapeutic Targets for Malignant Tumors
SOCS3: An Immunological Biomarker Offering Potential Therapeutic Targets for Malignant Tumors
Suppressor of Cytokine Signaling 3 (SOCS3) is a critical regulator of cytokine signaling, primarily acting through the Jan...
Sheet Protector Strategy for Western Blot to Reduce Antibody Consumption and Incubation Time
Sheet Protector Strategy for Western Blot to Reduce Antibody Consumption and Incubation Time
Western blot is one of the most routinely conducted biochemical assays due to its technical ease and relatively low cost. ...
Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy
Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy
HER2 expression has been confirmed to be associated with bladder cancer aggressiveness. Anti-HER2 RC48-ADC is approved in ...
Exploring the Mechanism of Canmei Formula in Preventing and Treating Recurrence of Colorectal Adenoma Based on Data Mining and Algorithm Prediction
Exploring the Mechanism of Canmei Formula in Preventing and Treating Recurrence of Colorectal Adenoma Based on Data Mining and Algorithm Prediction
The high incidence of recurrence and malignant transformation of colorectal adenoma (CRA) are current issues that need to ...
Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research
Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research
T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and e...
Celebrating World Cancer Day: Innovative Biological Approaches to Cancer and their Alignment with Sustainable Development Goals (SDGs)
Celebrating World Cancer Day: Innovative Biological Approaches to Cancer and their Alignment with Sustainable Development Goals (SDGs)
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies
Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies
Cancer poses significant economic and societal burdens on countries in the coming decades. During chemotherapy, patients f...
USP53 Affects the Proliferation and Apoptosis of Breast Cancer Cells by Regulating the Ubiquitination Level of ZMYND11
USP53 Affects the Proliferation and Apoptosis of Breast Cancer Cells by Regulating the Ubiquitination Level of ZMYND11
Breast cancer is the most common female malignancy worldwide. Ubiquitin-specific peptidase 53 (USP53) has been shown to ex...
Photodynamic Therapy: A Novel Approach for Head and Neck Cancer Treatment with Focusing on Oral Cavity
Photodynamic Therapy: A Novel Approach for Head and Neck Cancer Treatment with Focusing on Oral Cavity
Oral cancers, specifically oral squamous cell carcinoma (OSCC), pose a significant global health challenge, with high inci...
Short-term Outcome of RPVBT Combined with Chemotherapy for Patients with Single, < 3 cm, T2 Stage Bladder cancer
Short-term Outcome of RPVBT Combined with Chemotherapy for Patients with Single, < 3 cm, T2 Stage Bladder cancer
To investigate the survival outcome of “radical” GreenLight photoselective vaporization of bladder tumor (RPVB...
Effects and Mechanisms of the Xianhecao-Huanglian Drug Pair on Autophagy-Mediated Intervention in Acute Inflammatory Bowel Disease via the JAK2/STAT3 Pathway
Effects and Mechanisms of the Xianhecao-Huanglian Drug Pair on Autophagy-Mediated Intervention in Acute Inflammatory Bowel Disease via the JAK2/STAT3 Pathway
To explore the effects and mechanisms of the Xianhecao-Huanglian drug pair on autophagy-mediated intervention in acute inf...
Employing Raman Spectroscopy and Machine Learning for the Identification of Breast Cancer
Employing Raman Spectroscopy and Machine Learning for the Identification of Breast Cancer
Breast cancer poses a significant health risk to women worldwide, with approximately 30% being diagnosed annually in the U...
Development of an Interpretable Deep Learning Model for Pathological Tumor Response Assessment After Neoadjuvant Therapy
Development of an Interpretable Deep Learning Model for Pathological Tumor Response Assessment After Neoadjuvant Therapy
Neoadjuvant therapy followed by surgery has become the standard of care for locally advanced esophageal squamous cell carc...
Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy
Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy
The efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tum...
PMS2 amplification contributes brain metastasis from lung cancer
PMS2 amplification contributes brain metastasis from lung cancer
Lung adenocarcinoma metastasizing to the brain results in a notable increase in patient mortality. The high incidence and ...
Breaking the Mucin Barrier: A New Affinity Chromatography-Mass Spectrometry Approach to Unveil Potential Cell Markers and Pathways Altered in Pseudomyxoma Peritonei
Breaking the Mucin Barrier: A New Affinity Chromatography-Mass Spectrometry Approach to Unveil Potential Cell Markers and Pathways Altered in Pseudomyxoma Peritonei
Pseudomyxoma peritonei (PMP) is a rare peritoneal mucinous carcinomatosis with largely unknown underlying molecular mechan...
MicroRNA Nano-Shuttles: Engineering Extracellular Vesicles as a Cutting-Edge Biotechnology Platform for Clinical Use in Therapeutics
MicroRNA Nano-Shuttles: Engineering Extracellular Vesicles as a Cutting-Edge Biotechnology Platform for Clinical Use in Therapeutics
Extracellular vesicles (EVs) are nano-sized, membranous transporters of various active biomolecules with inflicting phenot...
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
The action of mesenchymal stem cells (MSCs) is the subject of intense research in the field of regenerative medicine, incl...
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway
Gastric cancer (GC) is a common malignancy and a leading cause of cancer-related death with high morbidity and mortality. ...
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Renal cancer therapies are challenging owing to the extensive spreading of this cancer to other organs and its ability to ...
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cance...
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
Ischemic stroke (IS) occurs when a blood vessel supplying the brain becomes obstructed, resulting in cerebral ischemia. Th...
Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site
Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site
Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One grou...
Extracellular Vesicles for Drug Delivery in Cancer Treatment
Extracellular Vesicles for Drug Delivery in Cancer Treatment
Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transpo...
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propen...
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Astrocytes have recently gained attention as key contributors to the pathogenesis of neurodegenerative disorders including...
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular ...
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell l...
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