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Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Introduction: Major depressive disorder (MDD), characterized by severe neuropsychiatric symptoms and significant cognitive...
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
IntroductionHelicobacter pylori causes chronic gastric diseases in nearly 50% of people around the world. It is suggested ...
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
BackgroundFluoroquinolones are broad-spectrum antibiotics with significant antimicrobial activity. Despite their therapeut...
Community pharmacists’ role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study
Community pharmacists’ role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study
IntroductionThe misuse or abuse and dependence of medications containing codeine continue to be a major global public heal...
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
IntroductionThe resolution of the skin’s inflammatory response is only possible if its barrier function is restored. TRPV1...
Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation
Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation
BackgroundSkin photoaging induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation manifests as skin roughness, de...
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Squamous cell carcinoma of the head and neck (HNSCC) is a difficult-to-treat cancer and treatment is challenging due to re...
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonl...
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset, limited unresponsiveness ...
Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections
Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections
There is clinical evidence showing that the Pelargonium sidoides root extract EPs 7630 is a safe and effective treatment f...
Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2
Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2
BackgroundDengue virus (DENV) infection, spread by Aedes aegypti mosquitoes, is a significant public health concern in tro...
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Background: Increasing student numbers and logistical challenges in pharmacy education limit patient counselling and clini...
Willingness to pay and price elasticity of demand for long-acting injectable cabotegravir among men who have sex with men in Guangxi, China
Willingness to pay and price elasticity of demand for long-acting injectable cabotegravir among men who have sex with men in Guangxi, China
ObjectivesThere is still no study focused on willingness to pay for long-acting injectable cabotegravir (CAB-LA) after it ...
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
IntroductionEthambutol, a key anti-tuberculosis medication, is associated with optic neuropathy, which can lead to signifi...
Naringenin modulates oxidative stress and lipid metabolism: Insights from network pharmacology, mendelian randomization, and molecular docking
Naringenin modulates oxidative stress and lipid metabolism: Insights from network pharmacology, mendelian randomization, and molecular docking
BackgroundPrevious studies have demonstrated that naringenin possesses lipid-lowering effects; however, the underlying mec...
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
IntroductionPolypharmacy is a growing concern in healthcare systems. While available data on potential drug-drug interacti...
Radiotherapy plus lenvatinib versus radiotherapy plus sorafenib for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study
Radiotherapy plus lenvatinib versus radiotherapy plus sorafenib for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study
Background and AimsPortal vein tumor thrombus (PVTT) occurs frequently in hepatocellular carcinoma (HCC) patients. However...
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
ObjectivesSingle-strand DNA-binding protein 1 (SSB1) plays a crucial role in the cellular response to DNA damage. This stu...
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
IntroductionDue to the high mortality rate and increasing severity of antibiotic resistance, there is a growing interest i...
Rapid identification of chemical profiles in vitro and in vivo of Huan Shao Dan and potential anti-aging metabolites by high-resolution mass spectrometry, sequential metabolism, and deep learning model
Rapid identification of chemical profiles in vitro and in vivo of Huan Shao Dan and potential anti-aging metabolites by high-resolution mass spectrometry, sequential metabolism, and deep learning model
BackgroundAging is marked by the gradual deterioration of cells, tissues, and organs and is a major risk factor for many c...
Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
BackgroundHyponatremia is a common electrolyte disturbance and known adverse drug reaction of diuretics. Women tend to be ...
Editorial: Advanced neural stem cell therapies for spinal cord injury
This edition of Frontiers in Pharmacology is dedicated to sharing the progress in spinal cord injury research. A total of ...
KIF11 promotes vascular smooth muscle cell proliferation by regulating cell cycle progression and accelerates neointimal formation after arterial injury in mice
KIF11 promotes vascular smooth muscle cell proliferation by regulating cell cycle progression and accelerates neointimal formation after arterial injury in mice
Background and aims: One of the primary causes of lumen narrowing is vascular injury induced during medical procedures. Va...
Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets
Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets
BackgroundAtrial fibrillation (AF) and breast cancer pose significant risks to human health. The reasons behind the concur...
Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients
Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients
Introduction and Background: Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels and is...
Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis
Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis
Introduction: Isoproterenol (ISO) is regarded as an adrenergic non-selective β agonist. It regulates myocardial contractil...
Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records
Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records
Background and ObjectiveChronic atrophic gastritis (CAG) is a complex chronic disease caused by multiple factors that freq...
The first-in-class pro-apoptotic peptide PEP-010 is effective in monotherapy and in combination with paclitaxel on resistant ovarian adenocarcinoma cell models
The first-in-class pro-apoptotic peptide PEP-010 is effective in monotherapy and in combination with paclitaxel on resistant ovarian adenocarcinoma cell models
Ovarian adenocarcinoma is the gynecological malignancy with the worst prognosis and the highest mortality rate. In the fir...
The forensic aspects of suicide and neurotrophin factors: a research study
The forensic aspects of suicide and neurotrophin factors: a research study
Introduction: Suicide represents a significant public health problem whose neurobiology is not yet fully understood. In ma...
The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
IntroductionPregnancy results in significant changes in drug pharmacokinetics (PK). While previous studies have elucidated...
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