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Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
BackgroundHyponatremia is a common electrolyte disturbance and known adverse drug reaction of diuretics. Women tend to be ...
Editorial: Advanced neural stem cell therapies for spinal cord injury
This edition of Frontiers in Pharmacology is dedicated to sharing the progress in spinal cord injury research. A total of ...
KIF11 promotes vascular smooth muscle cell proliferation by regulating cell cycle progression and accelerates neointimal formation after arterial injury in mice
KIF11 promotes vascular smooth muscle cell proliferation by regulating cell cycle progression and accelerates neointimal formation after arterial injury in mice
Background and aims: One of the primary causes of lumen narrowing is vascular injury induced during medical procedures. Va...
Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets
Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets
BackgroundAtrial fibrillation (AF) and breast cancer pose significant risks to human health. The reasons behind the concur...
Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients
Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients
Introduction and Background: Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels and is...
Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis
Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis
Introduction: Isoproterenol (ISO) is regarded as an adrenergic non-selective β agonist. It regulates myocardial contractil...
Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records
Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records
Background and ObjectiveChronic atrophic gastritis (CAG) is a complex chronic disease caused by multiple factors that freq...
The first-in-class pro-apoptotic peptide PEP-010 is effective in monotherapy and in combination with paclitaxel on resistant ovarian adenocarcinoma cell models
The first-in-class pro-apoptotic peptide PEP-010 is effective in monotherapy and in combination with paclitaxel on resistant ovarian adenocarcinoma cell models
Ovarian adenocarcinoma is the gynecological malignancy with the worst prognosis and the highest mortality rate. In the fir...
The forensic aspects of suicide and neurotrophin factors: a research study
The forensic aspects of suicide and neurotrophin factors: a research study
Introduction: Suicide represents a significant public health problem whose neurobiology is not yet fully understood. In ma...
The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
IntroductionPregnancy results in significant changes in drug pharmacokinetics (PK). While previous studies have elucidated...
CKD-497 inhibits NF-kB signaling and ameliorates inflammation and pulmonary fibrosis in ovalbumin-induced asthma and particulate matter-induced airway inflammatory diseases
CKD-497 inhibits NF-kB signaling and ameliorates inflammation and pulmonary fibrosis in ovalbumin-induced asthma and particulate matter-induced airway inflammatory diseases
Introduction: Air pollution, allergens, and bacterial infections are major contributors to pathological respiratory disord...
Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas
Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas
Introduction: Ferroptosis is a new mode of programmed cell death distinct from necrosis, apoptosis, and autophagy, induced...
Research progress and prospect of postoperative adjuvant therapy for resectable intrahepatic cholangiocarcinoma
Research progress and prospect of postoperative adjuvant therapy for resectable intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary malignancy of the liver, following hepatocellular ...
The application of rhubarb concoctions in traditional Chinese medicine and its compounds, processing methods, pharmacology, toxicology and clinical research
The application of rhubarb concoctions in traditional Chinese medicine and its compounds, processing methods, pharmacology, toxicology and clinical research
ObjectiveThis study reviews the development of rhubarb processing and the current status of pharmacological research. We s...
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity
With the advancing comprehension of immunology, an increasing number of immunotherapies are being explored and implemented...
Effect of dexmedetomidine on ncRNA and mRNA profiles of cerebral ischemia-reperfusion injury in transient middle cerebral artery occlusion rats model
Effect of dexmedetomidine on ncRNA and mRNA profiles of cerebral ischemia-reperfusion injury in transient middle cerebral artery occlusion rats model
Ischemic stroke poses a significant global health burden, with rapid revascularization treatments being crucial but often ...
EMT-related gene classifications predict the prognosis, immune infiltration, and therapeutic response of osteosarcoma
EMT-related gene classifications predict the prognosis, immune infiltration, and therapeutic response of osteosarcoma
BackgroundOsteosarcoma (OS), a bone tumor with high ability of invasion and metastasis, has seriously affected the health ...
Indications and adverse events of teriparatide: based on FDA adverse event reporting system (FAERS)
Indications and adverse events of teriparatide: based on FDA adverse event reporting system (FAERS)
BackgroundTeriparatide is approved for osteoporosis. Post-marketing surveillance is critical given its widespread use.Obje...
DaiTongXiao improves gout nephropathy by inhibiting inflammatory response through the TLR4/MyD88/NF-κB pathway
DaiTongXiao improves gout nephropathy by inhibiting inflammatory response through the TLR4/MyD88/NF-κB pathway
Introduction: Gouty nephropathy (GN) arises from factors like excessive purine intake, metabolic disorders or abnormal syn...
Prescription patterns and therapeutic gaps among persons with epilepsy in Southwestern Nigeria
Prescription patterns and therapeutic gaps among persons with epilepsy in Southwestern Nigeria
Introduction: Pharmacotherapy with antiseizure medications (ASMs) has been a cornerstone for achieving long-term remission...
Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions
Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions
In this review, we cover the current understanding of how radiation therapy, which uses ionizing radiation to kill cancer ...
Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells
Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells
Tetraethylammonium (TEA), a quaternary ammonium compound, is a well-known blocker of potassium channels belonging to vario...
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy
Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhyt...
Implementing the EU HTA regulation: Insights from semi-structured interviews on patient expectations, Belgian and European institutional perspectives, and industry outlooks
Implementing the EU HTA regulation: Insights from semi-structured interviews on patient expectations, Belgian and European institutional perspectives, and industry outlooks
Introduction: The goal of the Health Technology Assessment (HTA) Regulation 2021/2282 is to establish a more harmonized HT...
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Introduction: One of the primary obstacles faced by individuals with advanced colorectal cancer (CRC) is the potential dev...
How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?
How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?
Common bile duct stones, as a type of cholelithiasis, are a benign biliary obstruction that easily acute abdominalgia, and...
Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis
Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis
We performed a Bayesian network meta-analysis to indirectly compare the relative efficacy and safety of the latest JAK inh...
Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair
Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair
Cholangiocarcinoma (CCA) is a highly heterogeneous tumor that occurs in the bile duct epithelium; adenosquamous carcinoma ...
Access to a tailored mobile application enhances medication adherence among young users of antidepressants
Access to a tailored mobile application enhances medication adherence among young users of antidepressants
Introduction:Patients’ adherence to antidepressants is generally reported to be poor. This study examined whether users of...
Editorial: Structural and functional venomics as a powerful approach for drug discovery and development
Editorial: Structural and functional venomics as a powerful approach for drug discovery and development
The diversity of terrestrial and marine venomous creatures is extremely high with more than 200,000 species spread through...
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