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Evaluation of XSB-001 (Ranibizumab Biosimilar) Physicochemical and Biological Stability in Prepared Syringes for Intravitreal Injection
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Key Learnings from Clinical Research and Real-World Evidence on Asfotase Alfa Effectiveness in Hypophosphatasia: 10 Years Post-Approval
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Firsekibart, an Anti-interleukin-1β Monoclonal Antibody, in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
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Real-World Effectiveness and Safety of Infliximab Biosimilar CT-P13 for Rheumatic Diseases: A National Observational Cohort Study (ReFLECT)
ReFLECT was a French multicenter, observational cohort study evaluating the effectiveness and safety of CT-P13, an inflixi...
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Pharmacokinetic Bioequivalence, Safety, and Immunogenicity of DMB-3115, an Ustekinumab Biosimilar, and EU- and US-Stelara in Healthy Adult Participants: A Randomized, Double-Blind, Single-Dose Study
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Body Mass Index Progression, Development of Complications and Healthcare Costs Over 8 Years in UK Individuals Living With Overweight/Obesity
A detailed understanding of the risk factors for and impacts of body mass index (BMI) progression in people living with ob...
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Efficacy and Safety Maintained up to 3 Years in Adults with Paroxysmal Nocturnal Hemoglobinuria Receiving Pegcetacoplan
Pegcetacoplan, the first C3 and C3b inhibitor for paroxysmal nocturnal hemoglobinuria (PNH), demonstrated efficacy and saf...
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Long-Term Safety and Efficacy of Pemafibrate to Treat Hyperlipidemia: Post-marketing Surveillance Over a 24-Month Observation Period in Japan
Pemafibrate was well tolerated and effective in clinical trials that led to its approval to treat hyperlipidemia. However,...
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Preferences for Injectable Lipid-Lowering Therapies in Japanese Patients with Atherosclerotic Cardiovascular Disease: Findings from a Japanese Cross-sectional Study
Understanding patient preferences for injectable lipid-lowering therapies (LLTs) is crucial for optimizing adherence and o...
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Superior Bioavailability of a Novel 1.5% Ashwagandha Formulation (Zenroot™): A Randomized, Double-Blind, Single-Dose, Comparative, Oral Bioavailability Study in Healthy Adults
Ashwagandha has multiple medicinal properties and is widely used as a supplement to address various health conditions incl...
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Clinical and Humanistic Burden of Adult Obesity in Asia–Pacific: A Systematic Literature Review
Obesity continues to be an increasing global health concern. However, the burden of obesity within the Asia–Pacific ...
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Five Data-Informed Principles for Advancing Inclusive Research in Clinical Trials: A Pharma Perspective
Advancing inclusive research (AIR) in clinical trials requires frameworks and metrics for assessing real-world data and me...
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Comparative Effectiveness of Ciltacabtagene Autoleucel in CARTITUDE-4 Versus Real-World Physician’s Choice of Therapy from the Flatiron Registry in Lenalidomide-Refractory Multiple Myeloma
Ciltacabtagene autoleucel (cilta-cel) is approved for relapsed or refractory multiple myeloma (RRMM). In the CARTITUDE-4 s...
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Semaglutide 2.4 mg Clinical Outcomes in Patients with Obesity or Overweight: A Real-World Retrospective Comparative Cohort Study
This study compared the effectiveness of semaglutide 2.4 mg vs. no treatment with obesity medication (OM) for red...
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Real-World Weight Loss Among Patients Initiating Semaglutide 2.4 mg and Enrolled in WeGoTogether, a Digital Self-Support Application
Semaglutide injection 2.4 mg (Wegovy®; hereafter referred to as semaglutide) was approved by the US Food and...
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Evaluation of Glycemia Risk Index and Continuous Glucose Monitoring Outcomes Following the Transition to an Advanced Hybrid Closed-Loop System in Type 1 Diabetes
Advanced hybrid closed-loop (AHCL) systems have shown promise in improving glycemic control in adults with type 1 diabetes...
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Correction to: Evolving Role of Viltolarsen for Treatment of Duchenne Muscular Dystrophy
Bladen CL, Salgado D, Monges S, Foncuberta ME, Kekou K, Kosma K, Dawkins H, Lamont L, Roy AJ, Chamova T, Guergueltcheva V,...
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Impact of Continuous Glucose Monitoring and its Glucometrics in Clinical Practice in Spain and Future Perspectives: A Narrative Review
Continuous glucose monitoring (CGM) devices allow for 24-h real-time measurement of interstitial glucose levels and have c...
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Content Validity and Psychometric Evaluation of the Crohn’s Symptom Severity (CSS) Questionnaire in Patients with Moderately to Severely Active Crohn’s Disease
Individuals living with Crohn’s disease (CD) experience burdensome symptoms. As such, it is important to measure CD ...
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Psychological Factors Related to Treatment Outcomes in Head and Neck Cancer
Patients with head and neck cancer (HNC) often demonstrate stress, distress, anxiety, depression, and are at risk for&...
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A Real-World Comparison of Clinical Effectiveness in Patients with Rheumatoid Arthritis Treated with Upadacitinib, Tumor Necrosis Factor Inhibitors, and Other Advanced Therapies After Switching from an Initial Tumor Necrosis Factor Inhibitor
This study compared the clinical effectiveness of switching from tumor necrosis factor inhibitor (TNFi) to upadacitinib (T...
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Matched Comparison Examining the Effect of Obesity on Clinical, Economic, and Humanistic Outcomes in Patients with Bipolar I Disorder
Bipolar I disorder (BD-I) is associated with an increased risk of obesity, but few studies have evaluated the rea...
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Comparative Efficacy and Safety of Upadacitinib vs. Vedolizumab, Ustekinumab, and Tofacitinib After Induction and Maintenance for Ulcerative Colitis: Three Matching-Adjusted Indirect Comparisons
Evidence on the comparative efficacy and safety of approved therapies for ulcerative colitis (UC) during induction and mai...
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The Economic Burden of Childhood Ocular Morbidity in Bangladesh
Childhood eye morbidity is a great public health problem, especially in low-income countries. This study aimed to determin...
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The Broader Effects of Delayed Progression to End-Stage Kidney Disease: Delaying the Inevitable or a Meaningful Change?
A global rise in the prevalence of patients with chronic kidney disease (CKD) with end-stage kidney disease (ESKD) has led...
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Adherence, Persistence, Healthcare Resource Use, and Costs in Tofacitinib-Treated Patients with Psoriatic Arthritis: Data from Two United States Claims Databases
Associations between increased functional disability and higher healthcare resource utilization (HCRU) and costs were repo...
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Effects of Glucagon-Like Peptide 1 Receptor Agonists on Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Meta-analysis
Despite the technological advancements in catheter ablation strategies, the recurrence of atrial fibrillation (AF) post-ab...
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Real-World Treatment Persistence Among Advanced Therapy-Naïve or -Experienced Patients with Ulcerative Colitis Initiated on Ustekinumab or Adalimumab
Persistence on advanced therapies in ulcerative colitis (UC) is a useful real-world treatment performance measure. This st...
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Clinical and Humanistic Burden of Non-inhibitor Haemophilia A in Five European Countries: Insights from the CHESS II Study
Haemophilia A (HA) is a congenital bleeding disorder caused by a deficiency/absence of factor VIII (FVII...
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