Huang Z, Liu K, Ma W, Li D, Mo T, Liu Q. The gut microbiome in human health and disease-where are we and where are we going? Bibliometr Anal Front Microbiol. 2022;13:1018594.
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474(11):1823–36.
DeGruttola AK, Low D, Mizoguchi A, Mizoguchi E. Current understanding of dysbiosis in disease in human and animal models. Inflamm Bowel Dis. 2016;22(5):1137–50.
Levy M, Kolodziejczyk AA, Thaiss CA, Elinav E. Dysbiosis and the immune system. Nat Rev Immunol. 2017;17(4):219–32.
Hrncir T. Gut microbiota dysbiosis: triggers, consequences, diagnostic and therapeutic options. Microorganisms. 2022;10(3):578.
PubMed PubMed Central Google Scholar
Li Y, Xia S, Jiang X, et al. gut microbiota and diarrhea: an updated review. Front Cell Infect Microbiol. 2021;11:625210.
PubMed PubMed Central Google Scholar
Schippa S, Conte MP. Dysbiotic events in gut microbiota: impact on human health. Nutrients. 2014;6(12):5786–805.
PubMed PubMed Central Google Scholar
Arifin H, Rakhmawati W, Kurniawati Y, et al. Prevalence and determinants of diarrhea among under-five children in five Southeast Asian countries: evidence from the demographic health survey. J Pediatr Nurs. 2022;66:e37–45.
Ghosh K, Chakraborty AS, SenGupta S. Identifying spatial clustering of diarrhoea among children under 5 years across 707 districts in India: a cross sectional study. BMC Pediatr. 2023;23(1):272.
PubMed PubMed Central Google Scholar
World Health Organization. Diarrhoeal disease 2024. https://www.who.int/news-room/fact-sheets/detail/diarrhoeal-disease. Accessed on 31 January 2025.
Hill C, Guarner F, Reid G, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506–14.
Kesavelu D Sr, Rohit A, Karunasagar I, Karunasagar I. Composition and laboratory correlation of commercial probiotics in India. Cureus. 2020;12(11):e11334.
Merenstein D, Pot B, Leyer G, et al. Emerging issues in probiotic safety: 2023 perspectives. Gut Microbes. 2023;15(1):2185034.
PubMed PubMed Central Google Scholar
Szajewska H, Berni Canani R, Domellöf M, et al. Probiotics for the management of pediatric gastrointestinal disorders: position paper of the ESPGHAN special interest group on gut microbiota and modifications. J Pediatr Gastroenterol Nutr. 2023;76(2):232–47.
Yachha SK, Sarma MS, Mohan N, et al. Indian academy of pediatrics consensus guidelines for probiotic use in childhood diarrhea. Indian Pediatr. 2022;59(7):543–51.
Lefevre M, Racedo SM, Ripert G, et al. Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immun Ageing. 2015;12:24.
PubMed PubMed Central Google Scholar
Llewellyn A, Foey A. Probiotic modulation of innate cell pathogen sensing and signaling events. Nutrients. 2017;9(10):1156.
PubMed PubMed Central Google Scholar
Shida K, Nanno M, Nagata S. Flexible cytokine production by macrophages and T cells in response to probiotic bacteria: a possible mechanism by which probiotics exert multifunctional immune regulatory activities. Gut Microbes. 2011;2(2):109–14.
Ghelardi E, Abreu YAAT, Marzet CB, Álvarez Calatayud G, Perez M 3rd, Moschione Castro AP. Current progress and future perspectives on the use of Bacillus clausii. Microorganisms. 2022;10(6):1246.
CAS PubMed PubMed Central Google Scholar
Plomer M, Iii Perez M, Greifenberg DM. Effect of Bacillus clausii capsules in reducing adverse effects associated with Helicobacter pylori eradication therapy: a randomized, double-blind. Controll Trial Infect Dis Ther. 2020;9(4):867–78.
Sudha MR, Bhonagiri S, Kumar MA. Efficacy of Bacillus clausii strain UBBC-07 in the treatment of patients suffering from acute diarrhoea. Benef Microbes. 2013;4(2):211–6.
Kharwar A, Bazaz MR, Dandekar MP. Quantitative and qualitative characterization of commercially available oral suspension of probiotic products containing Bacillus clausii spores. BMC Microbiol. 2022;22(1):217.
CAS PubMed PubMed Central Google Scholar
Ianiro G, Rizzatti G, Plomer M, et al. Bacillus clausii for the treatment of acute diarrhea in children: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2018;10(8):1074.
PubMed PubMed Central Google Scholar
Lakshmi SG, Jayanthi N, Saravanan M, Ratna MS. Safety assesment of Bacillus clausii UBBC07, a spore forming probiotic. Toxicol Rep. 2017;4:62–71.
CAS PubMed PubMed Central Google Scholar
Dang HT, Tran DM, Phung TTB, et al. Promising clinical and immunological efficacy of Bacillus clausii spore probiotics for supportive treatment of persistent diarrhea in children. Sci Rep. 2024;14(1):6422.
CAS PubMed PubMed Central Google Scholar
Kesavelu D, Jog P. Current understanding of antibiotic-associated dysbiosis and approaches for its management. Ther Adv Infect Dis. 2023;10:20499361231154444.
CAS PubMed PubMed Central Google Scholar
Michel MC, Pellegrino P. A comprehensive review and meta-analysis on the treatment of acute gastroenteritis in children with a Bacillus clausii preparation (Enterogermina(®)). Adv Ther. 2025;42(7):3076–88.
Cutting SM. Bacillus probiotics. Food Microbiol. 2011;28(2):214–20.
Elshaghabee FMF, Rokana N, Gulhane RD, Sharma C, Panwar H. Bacillus as potential probiotics: status, concerns, and future perspectives. Front Microbiol. 2017;8:1490.
PubMed PubMed Central Google Scholar
Khatri I, Sharma G, Subramanian S. Composite genome sequence of Bacillus clausii, a probiotic commercially available as Enterogermina(®), and insights into its probiotic properties. BMC Microbiol. 2019;19(1):307.
CAS PubMed PubMed Central Google Scholar
Kolaček S, Hojsak I, Berni Canani R, et al. Commercial probiotic products: a call for improved quality control. A position paper by the ESPGHAN working group for probiotics and prebiotics. J Pediatr Gastroenterol Nutr. 2017;65(1):117–24.
Korona-Glowniak I, Siwiec R, Luszczewska-Sierakowska I, Maciejewski R, Wrobel R, Malm A. Microbiological evaluation of 10 commercial probiotic products available in Poland. Curr Issues Pharmacy Med Sci. 2019;32:121–4.
Latif A, Shehzad A, Niazi S, et al. Probiotics: mechanism of action, health benefits and their application in food industries. Front Microbiol. 2023;14:1216674.
PubMed PubMed Central Google Scholar
Indian Council of Medical Research Task Force, Co-ordinating Unit ICMR, Co-ordinating Unit DBT. ICMR-DBT guidelines for evaluation of probiotics in food. Indian J Med Res. 2011;134(1):22-5.
Vallabhaneni S, Walker TA, Lockhart SR, et al. Notes from the field: fatal gastrointestinal mucormycosis in a premature infant associated with a contaminated dietary supplement–Connecticut, 2014. MMWR Morb Mortal Wkly Rep. 2015;64(6):155–6.
PubMed PubMed Central Google Scholar
Mazzantini D, Calvigioni M, Celandroni F, Lupetti A, Ghelardi E. Spotlight on the compositional quality of probiotic formulations marketed worldwide. Front Microbiol. 2021;12:693973.
PubMed PubMed Central Google Scholar
Canganella F, Paganini S, Ovidi M, et al. A microbiological investigation on probiotic pharmaceutical products used for human health. Microbiol Res. 1997;152(2):171–9.
Coeuret V, Gueguen M, Vernoux JP. Numbers and strains of lactobacilli in some probiotic products. Int J Food Microbiol. 2004;97(2):147–56.
Drago L, De Vecchi E, Nicola L, Colombo A, Gismondo MR. Microbiological evaluation of commercial probiotic products available in Italy. J Chemother. 2004;16(5):463–7.
Drisko J, Bischoff B, Giles C, Adelson M, Rao RV, McCallum R. Evaluation of five probiotic products for label claims by DNA extraction and polymerase chain reaction analysis. Dig Dis Sci. 2005;50(6):1113–7.
Marinova VY, Rasheva IK, Kizheva YK, Dermenzhieva YD, Hristova PK. Microbiological quality of probiotic dietary supplements. Biotechnol Biotechnol Equip. 2019;33(1):834–41.
Ullah M, Raza A, Ye L, Yu Z. Viability and composition validation of commercial probiotic products by selective culturing combined with next-generation sequencing. Microorganisms. 2019;7(7):188.
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