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Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Alzheimer’s disease (AD) is the most common form of dementia. Characterized by progressive neurodegeneration, AD typ...
Treg Upregulation by Treadmill Training Accelerates Myelin Repair Post-Ischemia
Treg Upregulation by Treadmill Training Accelerates Myelin Repair Post-Ischemia
Regulatory T (Treg) cells contribute to white matter repair following ischemic stroke, but their limited availability in c...
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice
Spinal microglial activation and the polarization towards the M1 phenotype are implicated in the pathological process of n...
Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
The NLRP3 inflammasome signaling cascade activation is a significant contributor to the initiation and progression of Park...
Pharmacological Depletion of Microglia Protects Against Alcohol-Induced Corticolimbic Neurodegeneration During Intoxication in Male Rats
Pharmacological Depletion of Microglia Protects Against Alcohol-Induced Corticolimbic Neurodegeneration During Intoxication in Male Rats
Excessive alcohol use damages the brain, especially corticolimbic regions such as the hippocampus and rhinal cortices, lea...
Vinpocetine and Attenuated Rotenone-Induced Parkinson’s Disease and Restored Dopamine Synthesis in Rats through Modulation of Oxidative Stress, Neuroinflammation, and Lewy Bodies Inclusion
Vinpocetine and Attenuated Rotenone-Induced Parkinson’s Disease and Restored Dopamine Synthesis in Rats through Modulation of Oxidative Stress, Neuroinflammation, and Lewy Bodies Inclusion
Parkinson’s disease (PD) is the main neurodegenerative disorder affecting motor activity, there are different pathop...
A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders
A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders
Most current information about neurological disorders and diseases is derived from direct patient and animal studies. Howe...
Mitigating Remote Organ-Induced Brain Injury in Renal Ischemia-Reperfusion: The Role of Oleuropein in Inhibiting Oxidative Stress, Inflammation, Ferroptosis, and Apoptosis in Male Rats
Mitigating Remote Organ-Induced Brain Injury in Renal Ischemia-Reperfusion: The Role of Oleuropein in Inhibiting Oxidative Stress, Inflammation, Ferroptosis, and Apoptosis in Male Rats
Renal ischemia-reperfusion (RIR) induces brain damage as a distant organ. Oleuropein has antioxidant properties. This stud...
Correction: Reduction of Lewy Body Pathology by Oral Cinnamon
Correction: Reduction of Lewy Body Pathology by Oral Cinnamon
Cite this articleRaha, S., Dutta, D., Roy, A. et al. Correction: Reduction of Lewy Body Pathology by Oral Cinnamon. ...
Modulating Multiple Molecular Trajectories by Nutraceuticals and/or Physical Activity in Attention-Deficit/Hyperactivity Disorder (ADHD)-Like Behaviors in Rat Pups
Modulating Multiple Molecular Trajectories by Nutraceuticals and/or Physical Activity in Attention-Deficit/Hyperactivity Disorder (ADHD)-Like Behaviors in Rat Pups
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition affecting cognitive and social functions...
Correction: Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease
Correction: Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease
Cite this articleRangasamy, S.B., Dasarathi, S., Pahan, P. et al. Correction: Low-Dose Aspirin Upregulates Tyrosine Hydrox...
IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer’s Disease
IL-17 A Exacerbated Neuroinflammatory and Neurodegenerative Biomarkers in Intranasal Amyloid-Beta Model of Alzheimer’s Disease
Proinflammatory cytokines, especially interleukin-17 A (IL-17 A) have been found to be significantly ass...
Revisiting Migraine Pathophysiology: from Neurons To Immune Cells Through Lens of Immune Regulatory Pathways
Revisiting Migraine Pathophysiology: from Neurons To Immune Cells Through Lens of Immune Regulatory Pathways
Migraine is a prevalent neurological disorder characterized by severe, recurrent headaches accompanied by symptoms, such a...
Dapagliflozin Ameliorate Type-2 Diabetes Associated Neuropathy via Regulation of IGF-1R Signaling
Dapagliflozin Ameliorate Type-2 Diabetes Associated Neuropathy via Regulation of IGF-1R Signaling
Dapagliflozin, an approved SGLT2 inhibitor, has been shown to have extra-glycemic effects like cardio-reno protection. How...
Pentoxifylline Prevents Neuroinflammation and Modifies PTEN/TrkB Signaling in an LPS-Induced Depression Model
Pentoxifylline Prevents Neuroinflammation and Modifies PTEN/TrkB Signaling in an LPS-Induced Depression Model
Neuroinflammation affects patients with major depressive disorder and is linked to severe, treatment-resistant symptoms, m...
( +)-Catechin Alleviates CCI-Induced Neuropathic Pain by Modulating Microglia M1 and M2 Polarization via the TLR4/MyD88/NF-κB Signaling Pathway
( +)-Catechin Alleviates CCI-Induced Neuropathic Pain by Modulating Microglia M1 and M2 Polarization via the TLR4/MyD88/NF-κB Signaling Pathway
The aim of this research endeavor was to explore the therapeutic potential of ( +)-catechin in mitigating neuropathi...
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferroptosis in Hippocampal Neurons Via Activating the Nrf2/GPX4/SLC7A11 Pathway
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferroptosis in Hippocampal Neurons Via Activating the Nrf2/GPX4/SLC7A11 Pathway
Post-stroke depression (PSD) poses a serious impact on patients’ life quality. Effective drugs to treat this annoyin...
Irisin Regulates Microglia M1/M2 Polarization and Promotes Autophagy Through the Sirt3 Pathway to Alleviate POCD
Irisin Regulates Microglia M1/M2 Polarization and Promotes Autophagy Through the Sirt3 Pathway to Alleviate POCD
Cognitive impairment following surgical procedures, termed postoperative cognitive dysfunction (POCD), is a significant co...
Antioxidant-Effective Quercetin Through Modulation of Brain Interleukin-13 Mitigates Autistic-Like Behaviors in the Propionic Acid-Induced Autism Model in Rats
Antioxidant-Effective Quercetin Through Modulation of Brain Interleukin-13 Mitigates Autistic-Like Behaviors in the Propionic Acid-Induced Autism Model in Rats
Overproduction of reactive oxygen species occurs when inflammation induces oxidative stress in macrophages and microglia, ...
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis
Newly conducted research suggests that metabolic disorders, like diabetes and obesity, play a significant role as risk fac...
Recombinant Interleukin − 2 2 Immunotherapy Ameliorates Inflammation and Promotes the Release of Monoamine Neurotransmitters in the Gut-Brain Axis of Schistosoma mansoni-Infected Mice
Recombinant Interleukin − 2 2 Immunotherapy Ameliorates Inflammation and Promotes the Release of Monoamine Neurotransmitters in the Gut-Brain Axis of Schistosoma mansoni-Infected Mice
Recombinant interleukin-22 (rIL-22) has been reported as a protective agent in murine models of diseases driven by epithel...
Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response
Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response
Repetitive exposure of innate immune cells to a subthreshold dosage of endotoxin components may modulate inflammatory resp...
Canagliflozin Mitigated Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice: Role of AMPK/SIRT-1 Signaling Pathway in Modulating Neuroinflammation
Canagliflozin Mitigated Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice: Role of AMPK/SIRT-1 Signaling Pathway in Modulating Neuroinflammation
Sporadic Alzheimer’s disease (SAD) represents a major health concern especially among elderly. Noteworthy, neuroinfl...
Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression
Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression
The brain and immune system communicate through complex bidirectional pathways, but the specificity by which the brain per...
Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production
Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production
Neuroinflammation has been considered involved in the process of cerebral ischemia–reperfusion injury (CIRI). Transc...
Correction: FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Correction: FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, JS, 211166, ChinaShu Yao, Longjun Li, ...
Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke
Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke
Recent studies have demonstrated the interaction between gut microbiota and brain on ischemic stroke, but the roles of gut...
Hyperalgesic Effect Evoked by il-16 and its Participation in Inflammatory Hypernociception in Mice
Hyperalgesic Effect Evoked by il-16 and its Participation in Inflammatory Hypernociception in Mice
The systemic administration of interleukin-16 (IL-16, 3–30 ng/kg) induced thermal hyperalgesia in mice, tha...
The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity
The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity
Multiple Sclerosis (MS) is a debilitating disease that severely affects the central nervous system (CNS). Apart from neuro...
Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study
Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study
The mechanisms for neuropathic pain amelioration by sigma-1 receptor inhibition are not fully understood. We studied genom...
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