Murphy M, Bennett K, Wright M, et al. Potentially inappropriate prescribing in older adults with cancer receiving specialist palliative care: a retrospective observational study. Int J Clin Pharm. 2023;45(1):174–83. https://doi.org/10.1007/s11096-022-01506-4.

Article  PubMed  Google Scholar 

Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):1–10. https://doi.org/10.1186/s12877-017-0621-2.

Article  Google Scholar 

Alwidyan T, McCorry NK, Black C, et al. Prescribing and deprescribing in older people with life-limiting illnesses receiving hospice care at the end of life: a longitudinal, retrospective cohort study. Palliat Med. 2023;38(1):121–30. https://doi.org/10.1177/02692163231209024.

Article  PubMed  PubMed Central  Google Scholar 

Paque K, De Schreye R, Elseviers M, et al. Discontinuation of medications at the end of life: a population study in Belgium, based on linked administrative databases. Br J Clin Pharmacol. 2019;85(4):827–37. https://doi.org/10.1111/bcp.13874.

Article  PubMed  PubMed Central  Google Scholar 

Wenedy A, Lim YQ, Lin Ronggui CK, et al. A study of medication use of cancer and non-cancer patients in home hospice care in Singapore: a retrospective study from 2011 to 2015. J Palliat Med. 2019;22(10):1243–51. https://doi.org/10.1089/jpm.2018.0559.

Article  PubMed  Google Scholar 

Sato K, Miyashita M, Morita T, et al. End-of-life medical treatments in the last two weeks of life in palliative care units in Japan, 2005–2006: a nationwide retrospective cohort survey. J Palliat Med. 2016;19(11):1188–96. https://doi.org/10.1089/jpm.2016.0108.

Article  PubMed  Google Scholar 

Curtin D, Gallagher P, O’Mahony D. Deprescribing in older people approaching end-of-life: development and validation of STOPPFrail version 2. Age Ageing. 2021;50(2):465–71. https://doi.org/10.1093/ageing/afaa159.

Article  PubMed  Google Scholar 

Lee GB, Hosking SM, Etherton-Beer C, et al. Defining polypharmacy in older adults: a cross-sectional comparison of prevalence estimates calculated according to active ingredient and unique product counts. Int J Clin Pharm. 2025;47:1–10. https://doi.org/10.1007/s11096-025-01882-7.

Scott I, Hilmer S, Reeve E, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175(5):827–34. https://doi.org/10.1001/jamainternmed.2015.0324.

Article  PubMed  Google Scholar 

World Health Organization. Medication safety in polypharmacy: technical report. 2019. https://iris.who.int/bitstream/handle/10665/325454/WHO-UHC-SDS-2019.11-eng.pdf?sequence=1. Accessed 23 Jun 2025.

Hurley E, Dalton K, Byrne S, et al. Pharmacist-led deprescribing using STOPPFrail for frail older adults in nursing homes. J Am Med Dir Assoc. 2024;25(9): 105122. https://doi.org/10.1016/j.jamda.2024.105122.

Article  PubMed  Google Scholar 

Cardona M, Stehlik P, Fawzy P, et al. Effectiveness and sustainability of deprescribing for hospitalized older patients near end of life: a systematic review. Expert Opin Drug Saf. 2021;20(1):81–91. https://doi.org/10.1080/14740338.2021.1853704.

Article  PubMed  Google Scholar 

Curtin D, Jennings E, Daunt R, et al. Deprescribing in older people approaching end of life: a randomized controlled trial using STOPPFrail criteria. J Am Geriatr Soc. 2020;68(4):762–9. https://doi.org/10.1111/jgs.16278.

Article  PubMed  Google Scholar 

Hedman C, Frisk G, Björkhem-Bergman L. Deprescribing in palliative cancer care. Life (Basel). 2022;12(5): 613. https://doi.org/10.3390/life12050613.

Article  PubMed  CAS  Google Scholar 

Alwidyan T, McCorry NK, Parsons C. Healthcare professionals’ perspectives of deprescribing in older patients at the end of life in hospice care: a qualitative study using the theoretical domains framework. Int J Pharm Pract. 2023;31(3):305–13. https://doi.org/10.1093/ijpp/riad005.

Article  PubMed  Google Scholar 

Alwidyan T, Shamieh O, Parsons C, et al. Impact of the deprescribing timing on medicines optimisation in older cancer patients receiving hospice care at the end of life: a comparative cohort study. Eur Geriatr Med. 2025. https://doi.org/10.1007/s41999-025-01217-9.

Article  PubMed  Google Scholar 

Wang J, Shen JY, Yu F, et al. Challenges in deprescribing among older adults in post-acute care transitions to home. J Am Med Dir Assoc. 2024;25(1):138-45.e6. https://doi.org/10.1016/j.jamda.2023.09.021.

Article  PubMed  Google Scholar 

Le V, Patel N, Nguyen Q, et al. Retrospective analysis of a pilot pharmacist-led hospice deprescribing program initiative. J Am Geriatr Soc. 2021;69(5):1370–6. https://doi.org/10.1111/jgs.17122.

Article  PubMed  Google Scholar 

Marin H, Mayo P, Thai V, et al. The impact of palliative care consults on deprescribing in palliative cancer patients. Sup Care Cancer. 2020;28(9):4107–13. https://doi.org/10.1007/s00520-019-05234-w.

Article  Google Scholar 

Dalin DA, Vermehren C, Jensen AK, et al. Systematic medication review in general practice by an interdisciplinary team: a thorough but laborious method to address polypharmacy among elderly patients. Pharmacy (Basel). 2020;8(2): 57. https://doi.org/10.3390/pharmacy8020057.

Article  PubMed  Google Scholar 

Radcliffe E, Servin R, Cox N, et al. What makes a multidisciplinary medication review and deprescribing intervention for older people work well in primary care? A realist review and synthesis. BMC Geriatr. 2023;23(1):591. https://doi.org/10.1186/s12877-023-04256-8.

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization. Medication without harm: policy brief. 2024. https://iris.who.int/bitstream/handle/10665/376212/9789240062764-eng.pdf?sequence=1. Accessed 23 Jun 2025

World Health Organization. Medication without harm. 2017. https://iris.who.int/bitstream/handle/10665/255263/WHO-HIS-SDS-2017.6-eng.pdf. Accessed 23 Jun 2025

Tjia J, Clayton MF, Puerto G, et al. Shared medication PLanning in home hospice to address medication regimen complexity and family caregiver burden: a brief report. J Palliat Med. 2024;27(12):1653–6. https://doi.org/10.1089/jpm.2024.0229.

Article  PubMed  Google Scholar 

Vasilevskis EE, Shah AS, Hollingsworth EK, et al. Deprescribing medications among older adults from end of hospitalization through postacute care: a Shed-MEDS randomized clinical trial. JAMA Intern Med. 2023;183(3):223–31. https://doi.org/10.1001/jamainternmed.2022.6545.

Article  PubMed  PubMed Central  Google Scholar 

Elsten EE, Pot IE, Geijteman EC, et al. Recommendations for deprescribing of medication in the last phase of life: an international Delphi study. J Pain Symptom Manage. 2024;68(5):443-55.e2. https://doi.org/10.1016/j.jpainsymman.2024.07.029.

Article  PubMed  Google Scholar 

Greater Manchester Health and Social Care Partnership. Palliative care pain and symptom control guidelines for adults. 2019. https://www.england.nhs.uk/north-west/wp-content/uploads/sites/48/2020/01/Palliative-Care-Pain-and-Symptom-Control-Guidelines.pdf. Accessed 7 Jan 2024

Hui D, Nooruddin Z, Didwaniya N, et al. Concepts and definitions for “actively dying”,“end of life”,“terminally ill”,“terminal care”, and “transition of care”: a systematic review. J Pain Symptom Manage. 2014;47(1):77–89. https://doi.org/10.1016/j.jpainsymman.2013.02.021.

Article  PubMed  Google Scholar 

George J, Phun Y-T, Bailey MJ, et al. Development and validation of the medication regimen complexity index. Ann Pharmacother. 2004;38(9):1369–76.

Article  PubMed  Google Scholar 

Tjia J, Karakida M, Alcusky M, et al. Perspectives on deprescribing in palliative care. Expert Rev Clin Pharmacol. 2023;16(5):411–21. https://doi.org/10.1080/17512433.2023.2197592.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lavan AH, O’Mahony D, Gallagher P. Stoppfrail (screening tool of older persons’ prescriptions in frail adults with a limited life expectancy) criteria: application to a representative population awaiting long-term nursing care. Eur J Clin Pharmacol. 2019;75(5):723–31. https://doi.org/10.1007/s00228-019-02630-3.

Article  PubMed  Google Scholar 

Sevilla-Sánchez D, Molist-Brunet N, Espaulella-Panicot J, et al. Potentially inappropriate medication in palliative care patients according to STOPP-frail criteria. Eur Geriatr Med. 2018;9(4):543–50. https://doi.org/10.1007/s41999-018-0073-z.

Article  PubMed  Google Scholar 

Masumoto S, Hosoi T, Nakamura T, et al. Polypharmacy and potentially inappropriate medications in patients with advanced cancer: prevalence and associated factors at the end of life. J Palliat Med. 2024;27(6):749–55. https://doi.org/10.1089/jpm.2023.0520.

Article  PubMed  Google Scholar 

Kim S, Park S, Yoo SH, et al. Potentially inappropriate medication use based on two deprescribing criteria and related factors in patients with terminal cancer: a cross-sectional study. J Geriatr Oncol. 2023;14(3): 101472. https://doi.org/10.1016/j.jgo.2023.101472.

Article  PubMed