Impact of moderate to vigorous physical activity on systemic vascular resistance in Danish adults with recently diagnosed type 2 diabetes: a cross-sectional study

Rossier BC, Bochud M, Devuyst O. The hypertension pandemic: an evolutionary perspective. Physiology. 2017;32:112–25.

CAS  PubMed  Google Scholar 

Julius S. Phenotypic changes in the transition from prehypertension to established hypertension. In: Berbari AE, Mancia G, editors. Disorders of blood pressure regulation: phenotypes, mechanisms, therapeutic options. Cham: Springer International Publishing; 2018. pp. 587–98.

Lu DY, Fang Q, Bibby D, Arora B, Schiller NB. Association of systemic vascular resistance analog and cardiovascular outcomes: The Heart and Soul Study. J Am Heart Assoc. 2022;11:e026016.

PubMed  PubMed Central  Google Scholar 

Petrie JR, Guzik TJ, Touyz RM. Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Can J Cardiol. 2018;34:575–84.

PubMed  Google Scholar 

Lastra G, Syed S, Kurukulasuriya LR, Manrique C, Sowers JR. Type 2 diabetes mellitus and hypertension. Endocrinol Metab Clin North Am. 2014;43:103–22.

PubMed  Google Scholar 

Rijal A, Nielsen EE, Adhikari TB, Dhakal S, Maagaard M, Piri R, et al. Effects of adding exercise to usual care in patients with either hypertension, type 2 diabetes or cardiovascular disease: a systematic review with meta-analysis and trial sequential analysis. Br J Sports Med. 2023;57:930–9.

PubMed  Google Scholar 

Carey RM, Moran AE, Whelton PK. Treatment of hypertension. JAMA. 2022;328:1849.

CAS  PubMed  Google Scholar 

Fagard RH. Exercise is good for your blood pressure: effects of endurance training and resistance training. Clin Exp Pharmacol Physiol. 2006;33:853–6.

CAS  PubMed  Google Scholar 

McDonnell, Maki-Petaja BJ, Munnery KM, Yasmin M, Wilkinson IB, Cockcroft JR, et al. Habitual exercise and blood pressure: age dependency and underlying mechanisms. Am J Hypertens. 2013;26:334–41.

PubMed  Google Scholar 

Ring M, Eriksson MJ, Fritz T, Nyberg G, Östenson CG, Krook A, et al. Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance. Diab Vasc Dis Res. 2015;12:315–24.

PubMed  Google Scholar 

Loimaala A, Huikuri HV, Kööbi T, Rinne M, Nenonen A, Vuori I. Exercise training improves baroreflex sensitivity in type 2 diabetes. Diabetes. 2003;52:1837–42.

CAS  PubMed  Google Scholar 

Sacre JW, Holland DJ, Jenkins C, Sharman JE. Augmentation index immediately after maximal exercise in patients with type 2 diabetes mellitus. Med Sci Sports Exerc. 2012;44:75–83.

CAS  PubMed  Google Scholar 

Stidsen JV, Nielsen JS, Henriksen JE, Friborg SG, Thomsen RW, Olesen TB, et al. Protocol for the specialist supervised individualised multifactorial treatment of new clinically diagnosed type 2 diabetes in general practice (IDA): a prospective controlled multicentre open-label intervention study. BMJ Open. 2017;7:e017493.

PubMed  PubMed Central  Google Scholar 

Nielsen JS, Thomsen RW, Steffensen C, Christiansen JS. The Danish centre for strategic research in type 2 Diabetes (DD2) study: implementation of a nationwide patient enrollment system. Clin Epidemiol. 2012;4:27–36.

PubMed  PubMed Central  Google Scholar 

Faini A, Omboni S, Tifrea M, Bubenek S, Lazar O, Parati G. Cardiac index assessment: validation of a new non-invasive very low current thoracic bioimpedance device by thermodilution. Blood Press. 2014;23:102–8.

PubMed  Google Scholar 

Talvik A, Rebora P, Heinpalu-Kuum M, Salerno S, Miszkowska-Nagórna E, Liu X, et al. Non-invasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients: effects on home blood pressure in the BEAUTY study. Blood Press. 2018;27:368–75.

PubMed  Google Scholar 

Brønd JC, Aadland E, Andersen LB, Resaland GK, Andersen SA, Arvidsson D. The ActiGraph counts processing and the assessment of vigorous activity. Clin Physiol Funct Imaging. 2019;39:276–83.

PubMed  Google Scholar 

Domazet SL, Tarp J, Thomsen RW, Højlund K, Stidsen JV, Brønd JC, et al. Accelerometer-derived physical activity and sedentary behaviors in individuals with newly diagnosed type 2 diabetes: a cross-sectional study from the Danish nationwide DD2 cohort. Front Sports Act Living. 2022;4:1089579.

PubMed  Google Scholar 

Ahrensberg H, Toftager M, Nørgaard S, Petersen CB. Fysisk aktivitet for voksne (18-64 år): Viden om sundhed og forebyggelse. Sundhedsstyrelsen, 2023. 79 p.

DeMers D, Wachs D. Physiology, Mean Arterial Pressure. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538226/.

Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604.

PubMed  PubMed Central  Google Scholar 

Hill NR, Levy JC, Matthews DR. Expansion of the homeostasis model assessment of β-cell function and insulin resistance to enable clinical trial outcome modeling through the interactive adjustment of physiology and treatment effects: iHOMA2. Diabetes Care. 2013;36:2324–30.

CAS  PubMed  PubMed Central  Google Scholar 

Kähönen E, Aatola H, Lehtimäki T, Haarala A, Sipilä K, Juonala M, et al. Influence of early life risk factors and lifestyle on systemic vascular resistance in later adulthood: the cardiovascular risk in young Finns study. Blood Press. 2021;30:367–75.

PubMed  Google Scholar 

Green DJ, Smith KJ. Effects of exercise on vascular function, structure, and health in humans. Cold Spring Harb Perspect Med. 2018;8:a029819.

PubMed  PubMed Central  Google Scholar 

MacIntosh BR, Murias JM, Keir DA, Weir JM. What is moderate to vigorous exercise intensity? Front Physiol. 2021;12:682233.

PubMed  PubMed Central  Google Scholar 

Bogaert YE, Linas S. The role of obesity in the pathogenesis of hypertension. Nat Clin Pract Nephrol. 2009;5:101–11.

CAS  PubMed  Google Scholar 

Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomed Pharmacother. 2021;137:111315.

CAS  PubMed  Google Scholar 

Di Pino A, DeFronzo RA. Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents. Endocr Rev. 2019;40:1447–67.

PubMed  PubMed Central  Google Scholar 

Thorp AA, Schlaich MP. Relevance of sympathetic nervous system activation in obesity and metabolic syndrome. J Diabetes Res. 2015;2015:341583.

PubMed  PubMed Central  Google Scholar 

Chen J, Wang X, Dong B, Liu C, Zhao J, Dong Y, et al. Cardiac function and exercise capacity in patients with metabolic syndrome: a cross-sectional study. Front Cardiovasc Med. 2022;9:974802.

PubMed  PubMed Central  Google Scholar 

Coutinho T, Borlaug BA, Pellikka PA, Turner ST, Kullo IJ. Sex differences in arterial stiffness and ventricular-arterial interactions. J Am Coll Cardiol. 2013;61:96–103.

PubMed  Google Scholar 

Krzesiński P, Stańczyk A, Gielerak G, Uziębło-Życzkowska B, Kurpaska M, Piotrowicz K, et al. Sex determines cardiovascular hemodynamics in hypertension. J Hum Hypertens. 2015;29:610–7.

PubMed  Google Scholar 

Raj A, Chakole S, Agrawal S, Gupta A, Khekade H, Prasad R, et al. The impact of menopause on cardiovascular aging: a comprehensive review of androgen influences. Cureus. 2023;15:e43569.

PubMed  PubMed Central  Google Scholar 

Joyner MJ, Wallin BG, Charkoudian N. Sex differences and blood pressure regulation in humans. Exp Physiol. 2016;101:349–55.

PubMed  Google Scholar 

Arvidsson D, Fridolfsson J, Börjesson M. Measurement of physical activity in clinical practice using accelerometers. J Intern Med. 2019;286:137–53.

CAS  PubMed  Google Scholar 

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