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The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in pre...
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G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic...
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SDF-1α mRNA therapy in peripheral artery disease
Stromal cell-derived factor-1 alpha (SDF-1α) is a promising target for therapeutic angiogenesis in ischemic diseases ...
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Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Vascular repair and regeneration are critical for tissue homeostasis. Endothelial colony forming cells (ECFCs) are vessel-...
Angiogenesis
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Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Vascular endothelial growth factor A (VEGF-A) is a key signalling protein that stimulates blood vessel development and rep...
Angiogenesis
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High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system t...
Angiogenesis
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An endothelial specific mouse model for the capillary malformation mutation p.R183Q
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is ...
Angiogenesis
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Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient ou...
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Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethy...
Angiogenesis
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Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Reconstruction of the microvascular network is essential for tissue regeneration and functional repair. However, inadequat...
Angiogenesis
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Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cau...
Angiogenesis
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Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesi...
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In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
Vascular endothelial cells in vivo are exquisitely regulated by their local environment, which is disrupted or absent when...
Angiogenesis
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Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis
Wound healing is an essential repair process, and impaired wound healing is a common and sometimes debilitating medical pr...
Angiogenesis
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RE: acute aortic dissection in a patient with hereditary hemorrhagic telangiectasia associated with juvenile polyposis due to SMAD4 mutation
Conflict of interest The authors declare no competing inter...
Angiogenesis
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UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes
Epigenetics is increasingly recognized as a crucial factor in angiogenesis. Ubiquitin-like with PHD and RING Finger Domain...
Angiogenesis
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MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14
Critical limb ischemia (CLI) is a refractory peripheral artery disease characterized by tissue ischemia, presenting signif...
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Pathophysiology of endothelial dysfunction in Fontan circulation: from bench to bedside and back again
The Fontan procedure is a definitive surgical approach for complex cardiac malformations, redirecting systemic venous bloo...
Angiogenesis
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G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway
Vascular permeability, crucial for organ function, relies on the endothelial barrier formed by intercellular junctions (AJ...
Angiogenesis
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Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex. The LIC1 s...
Angiogenesis
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Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
Angiogenesis
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Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by ...
Angiogenesis
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Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular g...
Angiogenesis
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Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesi...
Angiogenesis
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Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead...
Angiogenesis
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Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on ...
Angiogenesis
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Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor recep...
Angiogenesis
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Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
COVID-19 is an endothelial disease with two key aspects: endotheliopathy causing coagulopathy and angiogenic disorder, par...
Angiogenesis
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Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist...
Angiogenesis
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A novel quantitative angiogenesis assay based on visualized vascular organoid
Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease pr...
Angiogenesis
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