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Identification of PANoptosis-relevant subgroups and predicting signature to evaluate the prognosis and immune landscape of patients with biliary tract cancer
Identification of PANoptosis-relevant subgroups and predicting signature to evaluate the prognosis and immune landscape of patients with biliary tract cancer
This study conducted molecular subtyping of biliary tract cancer patients based on 19 PANoptosis-related gene signatures. ...
Management and treatment of severe immune-related hepatotoxicity based on clinical and pathological characteristics
Management and treatment of severe immune-related hepatotoxicity based on clinical and pathological characteristics
The management of severe immune-related hepatotoxicity (irH) needs to be further optimized. This study aims to analyze the...
APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024
APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024
In Asia–Pacific region, hepatocellular carcinoma is a serious health threat attributing to over 600,000 deaths each ...
The effect of transition timing of regorafenib on treatment outcomes in unresectable hepatocellular carcinoma: a real-world study
The effect of transition timing of regorafenib on treatment outcomes in unresectable hepatocellular carcinoma: a real-world study
Regorafenib is the recommended second-line therapy for unresectable hepatocellular carcinoma (uHCC). Our study aimed to as...
Effects of dapagliflozin on liver steatosis in patients with nonalcoholic fatty liver disease: a randomized controlled trial
Effects of dapagliflozin on liver steatosis in patients with nonalcoholic fatty liver disease: a randomized controlled trial
Nonalcoholic fatty liver disease (NAFLD) is a common liver comorbidity with considerable global consequences. This study e...
Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
The pivotal role of antibody-producing B cells in controlling hepatitis B virus (HBV) infection is well-established. Howev...
Low-risk individuals with primary biliary cholangitis and significant liver stiffness: prognosis and treatment
Low-risk individuals with primary biliary cholangitis and significant liver stiffness: prognosis and treatment
Some patients treated with ursodeoxycholic acid (UDCA) or combined fenofibrate had well-controlled biochemical parameters ...
MAFLD but not MASLD increases risk of all-cause mortality in regional Australia, with components of metabolic syndrome exacerbating factors: 20 year longitudinal, cohort study
MAFLD but not MASLD increases risk of all-cause mortality in regional Australia, with components of metabolic syndrome exacerbating factors: 20 year longitudinal, cohort study
Controversy remains whether the mortality risk in people with fatty liver disease (FLD) including metabolic-(dysfunction) ...
Targeted APT8(16–34) obtained by cell-SELEX and its internalization with miR-23-5p into activated hepatic stellate cells
Targeted APT8(16–34) obtained by cell-SELEX and its internalization with miR-23-5p into activated hepatic stellate cells
The activation of hepatic stellate cells play a pivotal role in the pathogenesis of hepatic fibrosis. However, the current...
Global, regional, and national temporal trends in incidence and mortality for liver cancer due to hepatitis B, 1990–2021: a decomposition and age-period-cohort analysis for the Global Burden of Disease Study 2021
Global, regional, and national temporal trends in incidence and mortality for liver cancer due to hepatitis B, 1990–2021: a decomposition and age-period-cohort analysis for the Global Burden of Disease Study 2021
This study comprehensively assessed the burden of liver cancer due to hepatitis B (LCHB) from 1990 to 2021, analyzing temp...
Rheumatoid factor levels indicate cryoglobulinemia severity in hepatitis B e antigen-negative hepatitis B virus carriers: a 7-year prospective cohort study
Rheumatoid factor levels indicate cryoglobulinemia severity in hepatitis B e antigen-negative hepatitis B virus carriers: a 7-year prospective cohort study
The phenotype of cryoglobulinemia in hepatitis B virus (HBV) carriers remains elusive. A 7-year prospective cohort of 648 ...
Predictive model for HBsAg clearance rate in chronic hepatitis B patients treated with pegylated interferon α-2b for 48 weeks
Predictive model for HBsAg clearance rate in chronic hepatitis B patients treated with pegylated interferon α-2b for 48 weeks
Chronic hepatitis B (CHB) is a major global health concern. This study aims to investigate the factors influencing hepatit...
Cell-free DNA methylation-based inflammation score as a marker for hepatocellular carcinoma among people living with HIV
Cell-free DNA methylation-based inflammation score as a marker for hepatocellular carcinoma among people living with HIV
People living with the human immunodeficiency virus (HIV) are at a greater risk of developing hepatocellular carcinoma (HC...
Nomograms should be noted
Nomograms should be noted
Omata M, Cheng AL, Kokudo N, Kudo M, Lee JM, Jia J, et al. Asia-Pacific clinical practice guidelines on the management of ...
Artificial intelligence in liver imaging: methods and applications
Artificial intelligence in liver imaging: methods and applications
Liver disease is regarded as one of the major health threats to humans. Radiographic assessments hold promise in terms of ...
Prevalence and impact on the outcome of myosteatosis in patients with cirrhosis: a systematic review and meta-analysis
Prevalence and impact on the outcome of myosteatosis in patients with cirrhosis: a systematic review and meta-analysis
Myosteatosis in cirrhotic patients has been evaluated in limited studies with conflicting results and no systematic review...
An algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
An algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
Both European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and t...
Dairy products intake and prevalence, incidence, and recovery of non-alcoholic fatty liver disease in Chinese population
Dairy products intake and prevalence, incidence, and recovery of non-alcoholic fatty liver disease in Chinese population
Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern. Modifiable factors such as diet and lifestyl...
Liver fibrosis showed a two-phase regression rate during long-term anti-HBV therapy by three-time biopsies assessments
Liver fibrosis showed a two-phase regression rate during long-term anti-HBV therapy by three-time biopsies assessments
Evidence has proven that liver fibrosis or even cirrhosis can be reversed by anti-HBV treatment. However, the difference o...
APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure
APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predi...
MAFLD as part of systemic metabolic dysregulation
MAFLD as part of systemic metabolic dysregulation
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. In recent years, a ne...
Efficacy and safety of precision-guided transjugular extrahepatic portosystemic shunt (TEPS) in the management of cavernous transformation of the portal vein with portal hypertension: a case series
Efficacy and safety of precision-guided transjugular extrahepatic portosystemic shunt (TEPS) in the management of cavernous transformation of the portal vein with portal hypertension: a case series
Performing a Transjugular intrahepatic portal system shunt (TIPS) in patients with portal vein cavernous transformation (C...
PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
To investigate whether protein induced by vitamin K antagonist-II (PIVKA-II) combined with alpha-fetoprotein (AFP) can imp...
The contribution of genetics and epigenetics to MAFLD susceptibility
The contribution of genetics and epigenetics to MAFLD susceptibility
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of devel...
Predicting response to non-selective beta-blockers with liver–spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices
Predicting response to non-selective beta-blockers with liver–spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices
Non-selective beta-blockers (NSBB) are used for primary prophylaxis in patients with liver cirrhosis and high-risk varices...
Incidence and predictors of hepatocellular carcinoma in NAFLD without diagnosed cirrhosis: a nationwide real-world U.S. study
Incidence and predictors of hepatocellular carcinoma in NAFLD without diagnosed cirrhosis: a nationwide real-world U.S. study
A substantial proportion of patients with nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) ...
Recompensation in treatment-naïve HBV-related decompensated cirrhosis: a 5-year multi-center observational study comparing patients with ascites and bleeding
Recompensation in treatment-naïve HBV-related decompensated cirrhosis: a 5-year multi-center observational study comparing patients with ascites and bleeding
Recompensation between patients with ascites and bleeding was unknown in treatment-naïve HBV-related decompensated ci...
How non-alcoholic fatty liver disease and cirrhosis affect the heart
How non-alcoholic fatty liver disease and cirrhosis affect the heart
Liver diseases affect the heart and the vascular system. Cardiovascular complications appear to be a leading cause of deat...
Ending stigmatizing language in alcohol and liver disease: a liver societies’ statement
Ending stigmatizing language in alcohol and liver disease: a liver societies’ statement
Authors and AffiliationsConsortiaEuropean Association for the Study of the LiverAmerican Association for the Study of Live...
Serial circulating tumor DNA profiling predicts tumor recurrence after liver transplantation for liver cancer
Serial circulating tumor DNA profiling predicts tumor recurrence after liver transplantation for liver cancer
Minimal residual disease (MRD) is proposed to be responsible for tumor recurrence. The role of circulating tumor DNA (ctDN...
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