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Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis
Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis
IntroductionColonisation of the gut microbiome during the neonatal period is crucial for establishing a defence against en...
Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer
Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer
In an article published in April 2022 in Gut, the authors introduced an enhancer-based classification system known as EpiC...
Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021
Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021
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Concerns about instrumental variable selection for biological effect versus uptake of proton pump inhibitors in Mendelian randomisation analysis
Concerns about instrumental variable selection for biological effect versus uptake of proton pump inhibitors in Mendelian randomisation analysis
A recent population-based cohort study found an association between proton pump inhibitor (PPI) prescription and risk of i...
Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg)
Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg)
Introduction Helicobacter pylori is a Gram-negative, microaerophilic bacterium that infects more than half of the human po...
Alcohol-associated hepatitis: a neutrophile disease?
Alcohol-associated hepatitis: a neutrophile disease?
Alcohol-associated hepatitis (AH) is the acute deterioration of alcohol-related liver disease (ArLD) with rapid onset or w...
Gastrointestinal syndromes in Parkinsons disease: risk factors or comorbidities?
Gastrointestinal syndromes in Parkinsons disease: risk factors or comorbidities?
With great interest, we read the article by Konings et al,1 in which the authors conducted a combined case–control and coh...
Oral bacteria accelerate pancreatic cancer development in mice
Oral bacteria accelerate pancreatic cancer development in mice
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Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Chronic obstructive pulmonary disease (COPD) is most often caused by long-term cigarette smoke (CS) inhalation and include...
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Serum antibodies to the autoantigen transglutaminase 2 (TG2) are increasingly harnessed to diagnose coeliac disease. Diagn...
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
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Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes
Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes
Video Abstract Disclaimer: this video summarises a scientific article published by BMJ Publishing Group Limited (BMJ). The...
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
Tumour-reactive T cells infiltrating solid tumours are often rendered exhausted, a cell differentiation state characterise...
Is acute necrotising pancreatitis a chronic disease?
Is acute necrotising pancreatitis a chronic disease?
Acute pancreatitis (AP) is a common disease with an annual incidence of 34 (23–49) per 100 000 population.1 Patients with ...
Ferritin--a promising biomarker in MASLD
Ferritin--a promising biomarker in MASLD
Human ferritins are expressed in essentially all cells of the human body. From an evolutionary perspective, human ferritin...
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
MessageEndoscopic neoplasia detection in inflammatory bowel disease (IBD) remains challenging. We developed and validated ...
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Chronic liver diseases are prevalent, particularly among patients with type 2 diabetes, who have a higher incidence of met...
Unusual cause of abdominal pain
Unusual cause of abdominal pain
An 18-year-old woman presented with a 4-day history of worsening abdominal pain. Physical examination revealed tenderness ...
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
IntroductionBarrett’s oesophagus (BO) is a precursor lesion for oesophageal adenocarcinoma (OAC) and provides an opportuni...
Fibrosis in IBD: from pathogenesis to therapeutic targets
Fibrosis in IBD: from pathogenesis to therapeutic targets
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Toning down the role of eosinophils in eosinophilic oesophagitis
Toning down the role of eosinophils in eosinophilic oesophagitis
Eosinophilic oesophagitis (EoE) is an immune-mediated disease of uncertain aetiology. The diagnosis of EoE relies on the e...
Antibiotic use and inflammatory bowel disease: number needed to harm? Authors reply
Antibiotic use and inflammatory bowel disease: number needed to harm? Authors reply
We thank Ludvigsson for his interest in our work and for providing additional insights. As noted, our joint works implicat...
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Oesophageal adenocarcinoma (OAC) is a devastating disease with an average 5-year survival of around 15%.1 Moreover, rates ...
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Recently, Lopes et al quantified the effect of modifiable lifestyle factors in inflammatory bowel disease (IBD) prevention...
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
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NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma
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Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
The gastrointestinal ecosystem has received the most attention when examining the contributions of the human microbiome to...
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma
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Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
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Diagnostic dilemma: a patient with diarrhoea
Diagnostic dilemma: a patient with diarrhoea
A Sudanese man in his early 40s was admitted to our tertiary healthcare centre with a 3-month history of abdominal pain, f...
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