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Gut microbiota and metabolites of cirrhotic portal hypertension: a novel target on the therapeutic regulation
Gut microbiota and metabolites of cirrhotic portal hypertension: a novel target on the therapeutic regulation
The regulatory role of gut microbiota and gut-derived metabolites through the gut-liver axis in the development of cirrhot...
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
Defective hepatitis C virus (HCV) genomes with deletion of the envelope region have been occasionally reported by short-re...
Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy
Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy
Prognosis of esophageal adenocarcinoma (EAC) is still poor. Therefore, the development of novel therapeutic modalities is ...
Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases
Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases
Overlapping clinical manifestations of irritable bowel syndrome (IBS) and IBS-like symptoms in patients with inflammatory ...
Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study
Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study
Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancr...
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study
Although atezolizumab plus bevacizumab (Atezo/Bev) therapy has been used as the preferred first-line treatment for advance...
Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses
Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses
Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus characterized by eosinophil ac...
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8
Intestinal fibrosis is one of the most frequent and severe complications of Crohn’s disease. Accumulating studies ha...
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Rapid skeletal muscle loss adversely affects the clinical outcomes of liver cirrhosis. However, the relationships between ...
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Wilson’s disease (WD) is a rare condition resulting from autosomal recessive mutations in ATP7B, a copper transporte...
The potential of an artificial intelligence for diagnosing MRI images in rectal cancer: multicenter collaborative trial
The potential of an artificial intelligence for diagnosing MRI images in rectal cancer: multicenter collaborative trial
An artificial intelligence-based algorithm we developed, mrAI, satisfactorily segmented the rectal tumor, rectum, and meso...
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis
The intake of high-fructose corn syrup (HFCS) may increase the risk of colorectal cancer (CRC). This study aimed to explor...
Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-instituti...
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
Hypoxic microenvironment is a common feature of most solid tumors including hepatocellular carcinoma (HCC). Vasculogenic m...
Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction
Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction
Recently, two molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) have been proposed: the “Classical”...
Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Immune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail...
The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
Achalasia is an esophageal motility disorder with an unknown etiology. We aimed to determine the pathogenesis of achalasia...
Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
The tumor microbiome has been characterized in several malignancies; however, no previous studies have investigated its ro...
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, re...
Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
We compared the efficacy, tolerability, and safety of oral sulfate tablets (OST, which contains simethicone) and 2 L-polye...
Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
Corticosteroids are recommended only for induction of remission in inflammatory bowel disease (IBD), including ulcerative ...
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine
Spermidine suppress oxidative stress and is involved in various disease pathogenesis including ulcerative colitis (UC). Ar...
A novel artificial intelligence-based endoscopic ultrasonography diagnostic system for diagnosing the invasion depth of early gastric cancer
A novel artificial intelligence-based endoscopic ultrasonography diagnostic system for diagnosing the invasion depth of early gastric cancer
We developed an artificial intelligence (AI)-based endoscopic ultrasonography (EUS) system for diagnosing the invasion dep...
What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?
What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?
In primary sclerosing cholangitis (PSC), it is important to understand the cholangiographic findings suggestive of maligna...
ALBI score predicts morphological changes in esophageal varices following direct-acting antiviral-induced sustained virological response in patients with liver cirrhosis
ALBI score predicts morphological changes in esophageal varices following direct-acting antiviral-induced sustained virological response in patients with liver cirrhosis
This study aimed to clarify the morphological changes in esophageal varices after achieving sustained virological response...
High-mobility group box 1 fragment ameliorates chronic pancreatitis induced by caerulein in mice
High-mobility group box 1 fragment ameliorates chronic pancreatitis induced by caerulein in mice
Chronic pancreatitis (CP) is a progressive disease characterized by pancreatic fibrosis for which effective treatment opti...
MicroRNA-223-3p levels in serum-derived extracellular vesicles predict regression of M2BPGi-based liver fibrosis after hepatitis C virus eradication by direct-acting antiviral agents
MicroRNA-223-3p levels in serum-derived extracellular vesicles predict regression of M2BPGi-based liver fibrosis after hepatitis C virus eradication by direct-acting antiviral agents
We retrospectively investigated microRNA (miRNA) levels in serum-derived extracellular vesicles (EVs) as predictive indica...
Reply to “Considerations for evaluating antibiotic prophylaxis in cirrhotic patients with upper gastrointestinal bleeding in real-world data”
Reply to “Considerations for evaluating antibiotic prophylaxis in cirrhotic patients with upper gastrointestinal bleeding in real-world data”
Cite this articleUeno, M., Fujiwara, T., Tokumasu, H. et al. Reply to “Considerations for evaluating antibiotic prophylaxi...
Thiopurines exert harmful effects on spermatogenesis in Nudt15R138C knock-in mice
Thiopurines exert harmful effects on spermatogenesis in Nudt15R138C knock-in mice
The association between thiopurine use and testicular reproductive functions remains unclear. In this study, we investigat...
Considerations for evaluating antibiotic prophylaxis in cirrhotic patients with upper gastrointestinal bleeding in real-world data
Considerations for evaluating antibiotic prophylaxis in cirrhotic patients with upper gastrointestinal bleeding in real-world data
Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1, Okamoto, Kamakura, Kanagawa, 247-8533, JapanC...
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