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BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization
BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization
Osteoporosis is characterized by reduced bone mass due to imbalanced bone metabolism. Exosomes derived from bone mesenchym...
Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling
Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling
Vascular calcification is a crucial pathophysiological process associated with age-related cardiovascular diseases. Elabel...
FUT8 upregulates CD36 and its core fucosylation to accelerate pericyte-myofibroblast transition through the mitochondrial-dependent apoptosis pathway during AKI-CKD
FUT8 upregulates CD36 and its core fucosylation to accelerate pericyte-myofibroblast transition through the mitochondrial-dependent apoptosis pathway during AKI-CKD
Activation of pericytes leads to renal interstitial fibrosis, but the regulatory mechanism of pericytes in the progression...
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2
Hyperoside (quercetin-3-O-β-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericu...
Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases
Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases
Smad5 (small mothers against decapentaplegic 5) protein is a receptor-regulated member of the Smad family proteins, mainly...
Th1 cells reduce the osteoblast-like phenotype in valvular interstitial cells by inhibiting NLRP3 inflammasome activation in macrophages
Th1 cells reduce the osteoblast-like phenotype in valvular interstitial cells by inhibiting NLRP3 inflammasome activation in macrophages
Inflammation is initiates the propagation phase of aortic valve calcification. The activation of NLRP3 signaling in macrop...
Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
Benign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critica...
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory a...
Sirtuins in intervertebral disc degeneration: current understanding
Sirtuins in intervertebral disc degeneration: current understanding
Intervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to...
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing numb...
The role of N-methyladenosine modification in acute and chronic kidney diseases
The role of N-methyladenosine modification in acute and chronic kidney diseases
N6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in...
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series ...
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain...
Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females
Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females
Acute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, an...
The linear ANRIL transcript P14AS regulates the NF-κB signaling to promote colon cancer progression
The linear ANRIL transcript P14AS regulates the NF-κB signaling to promote colon cancer progression
The linear long non-coding RNA P14AS has previously been reported to be dysregulated in colon cancer, but the mechanistic ...
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice
Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease a...
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome
Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute ...
Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression
Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression
Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflammatory activity in the context of several ...
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice
Anxiety and depression-like behaviors in allergic rhinitis (AR) are attracting attention, while the precise mechanism has ...
Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection
Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection
The MeltPro TB assay (MeltPro) is a molecular rapid diagnostic test designed for detecting resistance to antituberculosis ...
PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model
PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model
Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phos...
Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer
Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer
Colorectal cancer (CRC) is the third frequently diagnosed cancer with high incidence and mortality rate worldwide. Our pre...
Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice
Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice
Krüppel-like factor 10 (KLF10) is involved in a positive feedback loop that regulates transforming growth factor ^...
USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice
USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice
Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The...
Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury
Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury
It is widely acknowledged that cisplatin-induced nephrotoxicity hinders its efficacy during clinical therapy. Effective ph...
B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine
B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine
High doses of oral thiamine improve clinical fatigue scores in patients with quiescent inflammatory bowel disease (IBD) an...
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organel...
Leveraging a disulfidptosis-related signature to predict the prognosis and immunotherapy effectiveness of cutaneous melanoma based on machine learning
Leveraging a disulfidptosis-related signature to predict the prognosis and immunotherapy effectiveness of cutaneous melanoma based on machine learning
Disulfidptosis is a recently discovered programmed cell death pathway. However, the exact molecular mechanism of disulfidp...
Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery em...
Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) ...
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