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CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 gene editing technology, as an innovative biomedical tool, holds significant potential in the prevention and t...
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based m...
p16 Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
p16 Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
Severe sepsis can promote myocardial injury and cardiac dysfunction, but role of p16 in sepsis-induced myocardial injury r...
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observe...
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of ca...
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertensio...
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
Myocardial ischemia/reperfusion (I/R)-induced cell death, such as autophagy and ferroptosis, is a major contributor to car...
Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2
Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2
Here, we focused on the function of SOS2 in heart failure (HF) after acute myocardial infarction (AMI) and investigated th...
Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study
Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study
Lymphatic dysfunction contributes to congestion and end-organ damage in heart failure (HF), yet current therapies do not d...
Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism
Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism
Ischemic heart disease (IHD), especially acute myocardial infarction (AMI), has a high mortality rate and poses a great th...
Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway
Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway
Although apelin-13 has cardioprotective impact, its short half-life in the bloodstream has challenged its clinical applica...
Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data
Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data
Computational simulations are a powerful tool in the understanding, diagnosing, and treatment of cardiovascular diseases. ...
New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases
New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases
Post-translational modifications (PTMs), which are covalent alterations of proteins after their synthesis, are critical fo...
A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model
A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model
Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute p...
Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction
Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) constitute a promising therapy for myocardial infar...
RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management
RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management
Cardio-Kidney-Metabolic (CKM) Syndrome involves metabolic, kidney, and cardiovascular dysfunction, disproportionately affe...
Inhibition of Egr2 Protects against TAC-induced Heart Failure in Mice by Suppressing Inflammation and Apoptosis Via Targeting Acot1 in Cardiomyocytes
Inhibition of Egr2 Protects against TAC-induced Heart Failure in Mice by Suppressing Inflammation and Apoptosis Via Targeting Acot1 in Cardiomyocytes
Heart failure (HF) is a clinical syndrome caused by structural or functional abnormalities in heart. Egr2 has been reporte...
PLK1 Downregulation Attenuates ET-1-Induced Cardiomyocyte Hypertrophy by Suppressing the ERK1/2 Pathway
PLK1 Downregulation Attenuates ET-1-Induced Cardiomyocyte Hypertrophy by Suppressing the ERK1/2 Pathway
Cardiomyocyte hypertrophy is a key remodeling response to cardiac stress and an independent risk factor for heart failure....
A Kernel Attention-based Transformer Model for Survival Prediction of Heart Disease Patients
A Kernel Attention-based Transformer Model for Survival Prediction of Heart Disease Patients
Survival analysis is employed to scrutinize time-to-event data, with emphasis on comprehending the duration until the occu...
H-FABP as a Biomarker in Transient Ischemic Attack
H-FABP as a Biomarker in Transient Ischemic Attack
The study investigates the utility of heart fatty-acid binding protein (H-FABP) in distinguishing TIA from mimics. Data fr...
Clinical Outcome of Hypertrophic Cardiomyopathy in Probands with the Founder Variant c.913_914del in MYBPC3: A Slovenian Cohort Study
Clinical Outcome of Hypertrophic Cardiomyopathy in Probands with the Founder Variant c.913_914del in MYBPC3: A Slovenian Cohort Study
Hypertrophic cardiomyopathy is often caused by pathogenic MYBPC3 variants. The study of Italian patients with HCM and MYBP...
Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease
Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease
Intrapericardial administration has been proposed as an alternative delivery route of pharmacological agents via the bilam...
Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis
Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis
Comment on: Prieto-Vila M, Yoshioka Y, Kuriyama N, Okamura A, Yamamoto Y, Muranaka A,...
An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access
An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access
For the past 20 years, transcatheter aortic valve replacement (TAVR) has been the treatment of choice for symptom...
AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway
AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway
Absent in melanoma 2(AIM2) exacerbates atherosclerosis by inflammasome assembly. However, AIM2-mediated inflammation in di...
Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models
Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models
The Impella CP is a percutaneously inserted temporary left ventricular assist device used in clinical practice and in tran...
Assessment of CMR Feature-Tracking Age- and Sex-Dependent Right Ventricular Strain in a Healthy Caucasian Cohort
Assessment of CMR Feature-Tracking Age- and Sex-Dependent Right Ventricular Strain in a Healthy Caucasian Cohort
Right ventricular (RV) strain offers crucial diagnostic insights in cardiovascular and pulmonary disorders. Nonetheless, t...
Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics?
Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics?
Epidemiological studies have revealed that patients with higher levels of high-density lipoprotein cholesterol (HDL-C) wer...
Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) – A Prospective, Multicentre Cohort Study
Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) – A Prospective, Multicentre Cohort Study
Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the ...
Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics
Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics
After an arterial switch operation for complete transposition of the great arteries, neo-aortic root dilatation occurs, wi...
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