p16 Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance

Bauer ME, Perez SL, Main EK, Norman GS, Fish LJ, Caldwell MA, Allen C, Hughes BL, Gibbs RS, Smith KL. Near-miss and maternal sepsis mortality: A qualitative study of survivors and support persons. Eur J Obstet Gynecol Reprod Biol. 2024;1(299):136–42. https://doi.org/10.1016/j.ejogrb.2024.05.038.

Article  Google Scholar 

Kimball AB, Jemec GBE, Sayed CJ, Kirby JS, Prens E, Ingram JR, Garg A, Gottlieb AB, Szepietowski JC, Bechara FG, Giamarellos-Bourboulis EJ, Fujita H, Rolleri R, Joshi P, Dokhe P, Muller E, Peterson L, Madden C, Bari M, Zouboulis CC. Efficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double-blind, placebo-controlled, multicentre phase 3 trials. Lancet. 2024;403(10443):2504–19. https://doi.org/10.1016/S0140-6736(24)00101-6.

Article  PubMed  CAS  Google Scholar 

Whitehouse T, Hossain A, Perkins GD, Gordon AC, Bion J, Young D, McAuley D, Singer M, Lord J, Gates S, Veenith T, MacCallum NS, Yeung J, Innes R, Welters I, Boota N, Skilton E, Ghuman B, Hill M, Regan SE, Mistry D, Lall R. STRESS-L Collaborators. Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial. JAMA. 2023;330(17):1641–52. https://doi.org/10.1001/jama.2023.20134.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ren J, Ren B, Fu T, Ma Y, Tan Y, Zhang S, Li Y, Wang Q, Chang X, Tong Y. Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis. Int J Med Sci. 2024;21(6):983–93. https://doi.org/10.7150/ijms.94577.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gu X, Meng H, Peng C, Lin S, Li B, Zhao L, Yang X, Wang G, Cai W, Zhou J, Liu S, Wu P, Du Y, Jin J, Wang X. Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1. Clin Transl Med. 2023;13(6): e1308. https://doi.org/10.1002/ctm2.1308.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang X, Huang G, Zhang Z, Wang F, Liu Q, Du Y, Wang X, Gu X. P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress. Exp Gerontol. 2024;187: 112372. https://doi.org/10.1016/j.exger.2024.112372.

Article  PubMed  CAS  Google Scholar 

Kuroshima T, Kawaguchi S, Okada M. Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy. Int J Mol Sci. 2024;25(9):4710. https://doi.org/10.3390/ijms25094710.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gu X, Peng CY, Lin SY, Qin ZY, Liang JL, Chen HJ, Hou CX, Wang R, Du YQ, Jin JL, Yang ZJ. P16INK4a played a critical role in exacerbating acute tubular necrosis in acute kidney injury. Am J Transl Res. 2019;11(6):3850–61.

PubMed  PubMed Central  CAS  Google Scholar 

Liang Y, Gu T, Peng S, Lin Y, Liu J, Wang X, Huang X, Zhang X, Zhu J, Zhao L, Fan C, Wang G, Gu X, Lin J. p16INK4a Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin. Oxid Med Cell Longev. 2022;21(2022):3415528. https://doi.org/10.1155/2022/3415528.

Article  CAS  Google Scholar 

Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, Wang R, Mao Z, Zhang Y, Li Q, Zuo G, Miao D, Jin J. Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4. Clin Transl Med. 2022;12(4): e574.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sun J, Zhou L, Yang T, Deng B, Bao Y, Gu L, Wang H, Wang L. P16INK4a Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy. Oxid Med Cell Longev. 2023;18(2023):1696190. https://doi.org/10.1155/2023/1696190.

Article  CAS  Google Scholar 

Shi J, Sun J, Liu L, Shan T, Meng H, Yang T, Wang S, Wei T, Chen B, Ma Y, Wang Q, Wang H, Liu J, Wang L. P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway. Biochem Biophys Res Commun. 2022;5(595):62–8.

Article  Google Scholar 

Qi Z, Liu R, Ju H, Huang M, Li Z, Li W, Wang Y. microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis. Int J Biol Sci. 2023;19(13):4223–41. https://doi.org/10.7150/ijbs.82287.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gu X, Zhao L, Ye J, Chen L, Sui C, Li B, Wang X, Zhang J, Du Y. 1,25(OH)2D3 ameliorates doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome and oxidative stress. Exp Ther Med. 2023;26(3):413. https://doi.org/10.3892/etm.2023.12112.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang F, Gu X, Lin S, Wu Q, Sun Y, Zhang Q, Luo A, Feng X, Wang L, Xu L, Sun W, Tan W. Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells. Clin Immunol. 2024;259: 109883.

Article  PubMed  CAS  Google Scholar 

Jin J, Lv X, Chen L, Zhang W, Li J, Wang Q, Wang R, Lu X, Miao D. Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance. Aging Cell. 2014;13(5):797–809. https://doi.org/10.1111/acel.12236.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gu X, Gu B, Lv X, Yu Z, Wang R, Zhou X, Qiao W, Mao Z, Zuo G, Li Q, Miao D, Jin J. 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. Cell Death Dis. 2016;7(10): e2423. https://doi.org/10.1038/cddis.2016.300.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li J, Luo T, Zhao Y, Wang D, Jin Y, Wu Z, Yang G, Qi X. Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis. Biomed Pharmacother. 2024;175: 116748. https://doi.org/10.1016/j.biopha.2024.116748.

Article  PubMed  CAS  Google Scholar 

Saadatian Z, Mansoori Y, Nariman-Saleh-Fam L, Daraei A, Vahed SZ, Navid S, Nariman-Saleh-Fam Z. Peripheral blood mononuclear cells expression of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with significant or insignificant coronary artery stenosis. Sci Rep. 2023;13(1):18438. https://doi.org/10.1038/s41598-023-45146-8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu W, Shao R, Zhang S, Jin L, Liu R, Chen P, Hu J, Ma H, Wu B, Liang W, Luo X, Li J, Chen W, Xiong N, He B. Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study. Crit Care. 2024;28(1):115. https://doi.org/10.1186/s13054-024-04879-2.

Article  PubMed  PubMed Central  Google Scholar 

Liu H, Hu Q, Ren K, Wu P, Wang Y, Lv C. ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway. Mol Med. 2023;29(1):171. https://doi.org/10.1186/s10020-023-00769-5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Garrity K, Docherty C, Mangion K, Woodward R, Shaw M, Roditi G, Shelley B, Quasim T, McCall P, McPeake J. Characterizing Cardiac Function in ICU Survivors of Sepsis: A Pilot Study Protocol. CHEST Crit Care. 2024;2(1): 100050. https://doi.org/10.1016/j.chstcc.2024.100050.

Article  PubMed  PubMed Central  Google Scholar 

Wolf SJ, Audu CO, Moon JY, Joshi AD, Melvin WJ, Barrett EC, Mangum K, de Jimenez GS, Rocco S, Buckley S, Ahmed Z, Wasikowski R, Kahlenberg JM, Tsoi LC, Gudjonsson JE, Gallagher KA. Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL-1R signaling. Diabetes. 2024;13:db230968. https://doi.org/10.2337/db23-0968.

Article  CAS  Google Scholar 

Putnam CD, Broderick L, Hoffman HM. The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity. Immunol Rev. 2024;322(1):259–82. https://doi.org/10.1111/imr.13292.

Article  PubMed  CAS  Google Scholar 

Zhang L, Tang Y, Huang P, Luo S, She Z, Peng H, Chen Y, Luo J, Duan W, Xiong J, Liu L, Liu L. Role of NLRP3 inflammasome in central nervous system diseases. Cell Biosci. 2024;14(1):75. https://doi.org/10.1186/s13578-024-01256-y.

Article  PubMed  PubMed Central  CAS 

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