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Persistence of hepatitis E vaccine-induced antibody response across different dosage schedules and baseline serostatus
Persistence of hepatitis E vaccine-induced antibody response across different dosage schedules and baseline serostatus
Hepatitis E virus (HEV) infection is a major cause of acute viral hepatitis worldwide. The efficacy and safety of the HEV2...
Systematic review of the impact of intestinal microbiota on vaccine responses
Systematic review of the impact of intestinal microbiota on vaccine responses
The intestinal microbiota plays a critical role in host immunity and might contribute to the significant variation between...
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe vi...
Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation
Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation
We previously reported that mice immunized twice with a lipid nanoparticle vaccine comprising four monkeypox viral mRNAs r...
Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis
Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis
Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic revi...
DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection
DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection
DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed...
A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma
A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly prevalent malignancy with limited treatment efficacy despite advances in immune...
Development of broadly protective influenza B vaccines
Development of broadly protective influenza B vaccines
Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans ...
Intradermal vaccination with a phytoglycogen nanoparticle and STING agonist induces cytotoxic T lymphocyte-mediated antitumor immunity
Intradermal vaccination with a phytoglycogen nanoparticle and STING agonist induces cytotoxic T lymphocyte-mediated antitumor immunity
A critical aspect of cancer vaccine development is the formulation with effective adjuvants. This study evaluated whether ...
A rationally designed antigen elicits protective antibodies against multiple nosocomial Gram-positive pathogens
A rationally designed antigen elicits protective antibodies against multiple nosocomial Gram-positive pathogens
ESKAPE pathogens are responsible for complicated nosocomial infections worldwide and are often resistant to commonly used ...
A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes
A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes
The global spread of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses threatens poultry and public health...
A multi-targeting immunotherapy ameliorates multiple facets of Alzheimer’s disease in 3xTg mice
A multi-targeting immunotherapy ameliorates multiple facets of Alzheimer’s disease in 3xTg mice
Alzheimer’s disease (AD) is an intricate disorder involving amyloid deposits, neurofibrillary tangles, and chronic n...
Telomeric repeats in the commercial SB-1 vaccine facilitate viral integration and contribute to vaccine efficacy
Telomeric repeats in the commercial SB-1 vaccine facilitate viral integration and contribute to vaccine efficacy
Marek’s disease virus (MDV) integrates its genome into the telomeres of host chromosomes and causes fatal lymphomas ...
Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy
Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy
Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutra...
Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection
Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection
At the start of the Zika virus (ZIKV) epidemic in 2015, ZIKV spread across South and Central America, and reached parts of...
Using matrix assisted laser desorption ionisation mass spectrometry combined with machine learning for vaccine authenticity screening
Using matrix assisted laser desorption ionisation mass spectrometry combined with machine learning for vaccine authenticity screening
The global population is increasingly reliant on vaccines to maintain population health with billions of doses used annual...
Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination
Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination
The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality. Spike messenger RNA (mRNA...
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies...
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced ...
The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy
Vaccine development requires the conduct of clinical trials to generate the necessary safety, quality and efficacy data ne...
Author Correction: Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Strep A: challenges, opportunities, vaccine-based solutions, and economics
This collection of articles focuses on Streptococcus pyogenes (Strep A) vaccine research and innovation, with a focus on e...
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary
On 27–29th of September 2022, Wellcome convened an international multi-stakeholder workshop to discuss the use of Co...
Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Populations are ageing worldwide, with considerable time lived in ill-health, putting upwards pressure on healthcare budge...
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulati...
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
The Centers for Disease Control and Prevention announced in January 2023 a potential connection between administration of ...
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can i...
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bn...
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date ha...
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