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Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization
Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization
Vitamin D3-loaded lipid nanoparticles (Vit D3-LNP), integrated into an azulene cream, were developed to enhance the topica...
Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implant
Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implant
Knee osteoarthritis (OA), a degenerative joint disease, is increasingly prevalent worldwide and often results from a menis...
Isolation of bacterial extracellular vesicles from raw samples using a portable microstructured electrochemical device
Isolation of bacterial extracellular vesicles from raw samples using a portable microstructured electrochemical device
Bacterial extracellular vesicles (EVs) are nanosized vesicles released by both Gram-negative and Gram-positive bacteria, p...
Microneedle-mediated delivery of hydroxypropyl--cyclodextrin-encapsulated (Danggui) essential oil for acne treatment: efficacy and mechanisms
Microneedle-mediated delivery of hydroxypropyl--cyclodextrin-encapsulated (Danggui) essential oil for acne treatment: efficacy and mechanisms
Acne is a multifactorial dermatological condition driven by Propionibacterium acnes (P. acnes) infection, inflammation, an...
Oral colon-targeted paeonol emulsion for ameliorating ulcerative colitis based on charge adsorption
Oral colon-targeted paeonol emulsion for ameliorating ulcerative colitis based on charge adsorption
Ulcerative colitis (UC), an inflammatory bowel disease, poses a severe threat to human health. Paeonol has demonstrated po...
Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template
Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template
Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting ...
Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery
Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery
Hypoxia is a key feature of solid tumors, contributing to therapeutic resistance and poor prognosis. Targeting hypoxic env...
Muscle-targeting LNP vaccines enable potent immune responses against varicella zoster virus
Muscle-targeting LNP vaccines enable potent immune responses against varicella zoster virus
Messenger RNA (mRNA) therapeutics have shown considerable promise across a wide range of medical applications with lipid n...
Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson’s disease treatment by intranasal administration
Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson’s disease treatment by intranasal administration
The main aim of this work was to synthesize new chitosan amphiphilic derivatives able to self-assembly encapsulating subst...
Delivery of monoclonal antibodies to the brain: the impact of nanocarrier structure
Delivery of monoclonal antibodies to the brain: the impact of nanocarrier structure
Monoclonal antibodies (mAbs) are promising therapeutic agents for neurological disorders due to their high specificity. Ho...
Development of a microneedle patch for delivery of mRNA-lipid nanoparticles
Development of a microneedle patch for delivery of mRNA-lipid nanoparticles
mRNA delivered by microneedle patch (MNP) can enable painless delivery, reduced need for healthcare expertise, and improve...
Exploring topical atorvastatin hyalurosomal gel as an adjuvant for reducing systemic corticosteroid dosage: a randomized clinical trial in severe oral lichen planus patients
Exploring topical atorvastatin hyalurosomal gel as an adjuvant for reducing systemic corticosteroid dosage: a randomized clinical trial in severe oral lichen planus patients
Oral lichen planus (OLP) is a chronic inflammatory disorder with limited topical treatment options and long-term corticost...
Current status of Liraglutide delivery systems for the management of type 2 diabetes mellitus
Current status of Liraglutide delivery systems for the management of type 2 diabetes mellitus
Diabetes is a metabolic disorder of increasing global concern. Characterized by constantly elevated levels of glucose, sev...
Application and development prospects of bio-based smart responsive hydrogels in insulin delivery
Application and development prospects of bio-based smart responsive hydrogels in insulin delivery
The increasing prevalence of diabetes has made insulin formulations a cornerstone in the management of the disease. Howeve...
Image-guided in vivo evaluation and comparison of bone-targeting peptides for therapeutic intervention
Image-guided in vivo evaluation and comparison of bone-targeting peptides for therapeutic intervention
Hydroxyapatite (HA)-binding peptides hold strong potential for bone-targeted therapies due to their high affinity for mine...
Toward a harmonized regulatory framework for 3D-printed pharmaceutical products: the role of critical feedstock materials and process parameters
Toward a harmonized regulatory framework for 3D-printed pharmaceutical products: the role of critical feedstock materials and process parameters
The commercialization of additive manufacturing (AM) in pharmaceuticals manufacturing has attracted significant attention ...
PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
Melanoma is the main cause of death among skin cancers and its incidence worldwide has been experiencing an appalling incr...
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis (LF) occurs when the liver tissue responds to injury or inflammation by producing excessive amounts of scar...
Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery
Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery
The success of colon-targeted oral hybrid systems relies in the proper control over the release of the entrapped nanostruc...
Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
The first line of glaucoma treatment focuses on reducing intraocular pressure (IOP) through the prescription of topical pr...
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Several efforts have been extensively accomplished for the amelioration of the cancer treatments using different types of ...
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Allergic disease is a major global health concern that imposes significant life-altering and economic burdens on affected ...
Protease-activated CendR peptides targeting tenascin-C: mitigating off-target tissue accumulation
Protease-activated CendR peptides targeting tenascin-C: mitigating off-target tissue accumulation
To achieve precision and selectivity, anticancer compounds and nanoparticles (NPs) can be targeted with affinity ligands t...
Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that...
OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
Cerebrovascular impairment represents one of the main causes of death worldwide with a mortality rate of 5.5 million per y...
Lipid nanoparticles-based RNA therapies for breast cancer treatment
Lipid nanoparticles-based RNA therapies for breast cancer treatment
Breast cancer (BC) prevails as a major burden on global healthcare, being the most prevalent form of cancer among women. B...
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Fabry disease (FD) results from a lack of activity of the lysosomal enzyme α-Galactosidase A (α-Gal A), leading ...
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strate...
Glycyrrhizin functionalized CuS Nanoprobes for NIR Light-based therapeutic mitigation of acne vulgaris
Glycyrrhizin functionalized CuS Nanoprobes for NIR Light-based therapeutic mitigation of acne vulgaris
Acne Vulgaris or Acne is a multifactorial bacterial infection caused by Propionibacterium acne, leading to inflammation an...
In vivo evaluation of a Nano-enabled therapeutic vitreous substitute for the precise delivery of triamcinolone to the posterior segment of the eye
In vivo evaluation of a Nano-enabled therapeutic vitreous substitute for the precise delivery of triamcinolone to the posterior segment of the eye
This study focused on the design of a thermoresponsive, nano-enabled vitreous substitute for the treatment of retinal dise...
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