Pardi N, Hogan MJ, Porter FW, Weissman D. mRNA vaccines — a new era in vaccinology. Nat Rev Drug Discov. 2018;17(4):261–79. https://doi.org/10.1038/nrd.2017.243.
Article PubMed PubMed Central CAS Google Scholar
Chaudhary N, Weissman D, Whitehead KA. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat Rev Drug Discov. 2021;20(11):817–38. https://doi.org/10.1038/s41573-021-00283-5
Article PubMed PubMed Central CAS Google Scholar
Hassett KJ, Benenato KE, Jacquinet E, Lee A, Woods A, Yuzhakov O, Himansu S, Deterling J, Geilich BM, Ketova T, et al. Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines. Mol Ther - Nucleic Acids. 2019;15:1–11. https://doi.org/10.1016/j.omtn.2019.01.013.
Article PubMed PubMed Central CAS Google Scholar
McKay PF, Hu K, Blakney AK, Samnuan K, Brown JC, Penn R, Zhou J, Bouton CR, Rogers P, Polra K, et al. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nat Commun. 2020;11(1):3523. https://doi.org/10.1038/s41467-020-17409-9.
Article PubMed PubMed Central CAS Google Scholar
Alameh M-G, Tombácz I, Bettini E, Lederer K, Sittplangkoon C, Wilmore JR, Gaudette BT, Soliman OY, Pine M, Hicks P, et al. Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Immunity. 2022;55(6):1136–8. https://doi.org/10.1016/j.immuni.2022.05.007.
Article PubMed PubMed Central Google Scholar
Beck JD, Reidenbach D, Salomon N, Sahin U, Türeci Ö, Vormehr M, Kranz LM. mRNA therapeutics in cancer immunotherapy. Mol Cancer. 2021;20(1):69. https://doi.org/10.1186/s12943-021-01348-0
Article PubMed PubMed Central CAS Google Scholar
Liu C, Shi Q, Huang X, Koo S, Kong N, Tao W. mRNA-based cancer therapeutics. Nat Rev Cancer. 2023;23(8):526–43. https://doi.org/10.1038/s41568-023-00586-2.
Article PubMed CAS Google Scholar
Miao L, Li L, Huang Y, Delcassian D, Chahal J, Han J, Shi Y, Sadtler K, Gao W, Lin J, et al. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol. 2019;37(10):1174–85. https://doi.org/10.1038/s41587-019-0247-3.
Article PubMed CAS Google Scholar
Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, et al. An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma. Nature. 2020;585(7823):107–12. https://doi.org/10.1038/s41586-020-2537-9.
Article PubMed CAS Google Scholar
Zhang H, You X, Wang X, Cui L, Wang Z, Xu F, Li M, Yang Z, Liu J, Huang P, et al. Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling. Proc Natl Acad Sci. 2021;118(6):e2005191118. https://doi.org/10.1073/pnas.2005191118.
Article PubMed PubMed Central CAS Google Scholar
Sahu I, Haque AKMA, Weidensee B, Weinmann P, Kormann MSD. Recent developments in mRNA-Based protein supplementation therapy to target lung diseases. Mol Ther. 2019;27(4):803–23. https://doi.org/10.1016/j.ymthe.2019.02.019.
Article PubMed PubMed Central CAS Google Scholar
Vavilis T, Stamoula E, Ainatzoglou A, Sachinidis A, Lamprinou M, Dardalas I, Vizirianakis. IS. mRNA in the context of protein replacement therapy. Pharmaceutics. 2023;15(1):166. https://doi.org/10.3390/pharmaceutics15010166
Article PubMed PubMed Central CAS Google Scholar
Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KML, Tan X, Dunn AL, Kerlin BA, et al. An orthogonal array optimization of Lipid-like nanoparticles for mRNA delivery in vivo. Nano Lett. 2015;15(12):8099–107. https://doi.org/10.1021/acs.nanolett.5b03528.
Article PubMed PubMed Central CAS Google Scholar
Robinson E, MacDonald KD, Slaughter K, McKinney M, Patel S, Sun C, Sahay G. Lipid Nanoparticle-Delivered chemically modified mRNA restores chloride secretion in cystic fibrosis. Mol Ther. 2018;26(8):2034–46. https://doi.org/10.1016/j.ymthe.2018.05.014.
Article PubMed PubMed Central CAS Google Scholar
Veiga N, Goldsmith M, Granot Y, Rosenblum D, Dammes N, Kedmi R, Ramishetti S, Peer D. Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes. Nat Commun. 2018;9(1):1–9. https://doi.org/10.1038/s41467-018-06936-1.
Popovitz J, Sharma R, Hoshyar R, Soo Kim B, Murthy N, Lee K. Gene editing therapeutics based on mRNA delivery. Adv Drug Deliv Rev. 2023;200:115026. https://doi.org/10.1016/j.addr.2023.115026.
Article PubMed CAS Google Scholar
Li W, Wang C, Lu Y. When mRNA Meets gene editing. Nano Res. 2024;17(8):7337–56. https://doi.org/10.1007/s12274-024-6729-8.
Sun YH, Chatterjee S, Lian XZ, Traylor Z, Sattiraju SR, Xiao YF, Dilliard SA, Sung YC, Kim M, Lee SM, et al. In vivo editing of lung stem cells for durable gene correction in mice. Science. 2024;384(6701):1196–202. https://doi.org/10.1126/science.adk9428.
Article PubMed PubMed Central CAS Google Scholar
Li B, Manan RS, Liang S-Q, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D. Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. Nat Biotechnol. 2023;41(10):1410–5. https://doi.org/10.1038/s41587-023-01679-x.
Article PubMed PubMed Central CAS Google Scholar
Qiu M, Glass Z, Chen J, Haas M, Jin X, Zhao X, Rui X, Ye Z, Li Y, Zhang F, et al. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing ofAngptl3. Proc Natl Acad Sci. 2021;118(10):e2020401118. https://doi.org/10.1073/pnas.2020401118.
Article PubMed PubMed Central CAS Google Scholar
Wang T, Upponi JR, Torchilin VP. Design of multifunctional non-viral gene vectors to overcome physiological barriers: dilemmas and strategies. Int J Pharm. 2012;427(1):3–20. https://doi.org/10.1016/j.ijpharm.2011.07.013.
Article PubMed CAS Google Scholar
Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, et al. Efficiency of SiRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013;31(7):653–8. https://doi.org/10.1038/nbt.2614.
Article PubMed PubMed Central CAS Google Scholar
Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nat Rev Genet. 2014;15(8):541–55. https://doi.org/10.1038/nrg3763.
Article PubMed CAS Google Scholar
Sorrentino S. Human extracellular ribonucleases: multiplicity, molecular diversity and catalytic properties of the major RNase types. Cell Mol Life Sci. 1998;54(8):785–94.
Article PubMed PubMed Central CAS Google Scholar
Sean C, Semple AC, Pieter R, Cullis. Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo. Adv Drug Deliv Rev. 1998;32(1,2):3–17.
Hou X, Zaks T, Langer R, Dong Y. Lipid nanoparticles for mRNA delivery. Nat Rev Mater. 2021;6(12):1078–94. https://doi.org/10.1038/s41578-021-00358-0.
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