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Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder
WHAT IS ALREADY KNOWN ON THIS TOPICGenetic and environmental factors contribute to the pathogenesis of schizophrenia (SZ) ...
Estimating the smallest worthwhile difference of antidepressants: a cross-sectional survey
BackgroundDepression is the second leading cause of disability worldwide1 with millions seeking treatment through antidepr...
Thematic analysis of Prevention of Future Death reports for suicide: January 2021 to October 2022
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionIn the last three d...
Perfect storm: emotionally based school avoidance in the post-COVID-19 pandemic context
School absenteeism spiked during the COVID-19 pandemic and shows little sign of returning to pre-pandemic levels. In Engla...
Comorbid physical health burden of serious mental health disorders in 32 European countries
WHAT IS ALREADY KNOWN ON THIS TOPICPeople with mental health disorders experience worse physical health compared with the ...
Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study
BackgroundThe Global Burden of Disease Study in 2019 has revealed that mental disorders have consistently ranked among the...
Psychosis with use of amphetamine drugs, methylphenidate and atomoxetine in adolescent and adults
WHAT IS ALREADY KNOWN ON THIS TOPICInternational guidelines recommend psychostimulants (eg, methylphenidate, dexamfetamine...
Effectiveness of an online recovery training for employees exposed to blurred boundaries between work and non-work: Bayesian analysis of a randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSFor the first time, it is shown, that an online recovery training i...
Experiences and impact of psychiatric inpatient admissions far away from home: a qualitative study with young people, parents/carers and healthcare professionals
WHAT IS ALREADY KNOWN ON THIS TOPICService demand for inpatient care sometimes results in young people (YP) being admitted...
Mortality and adverse events associated with statin use in primary care patients with depression: a real-world, population-based cohort study
BackgroundStatins are a class of cholesterol-lowering drugs licensed for the prevention and treatment of cardiovascular an...
Hypersexuality in neurological disorders: A systematic review
WHAT IS ALREADY KNOWN ON THIS TOPICHypersexuality is an understudied behavioural complication across neurological conditio...
Paediatric traumatic brain injury and attention-deficit/hyperactivity disorder medication in Finland: a nationwide register-based cohort study
BackgroundA traumatic brain injury (TBI) is characterised by a disruption of normal brain function or structure caused by ...
Changes in the prevalence of mental health problems during the first year of the pandemic: a systematic review and dose-response meta-analysis
IntroductionMental health is a major public health concern.1 Mental health conditions have long been and still are underdi...
Severe psychiatric disorders are associated with increased risk of dementia
WHAT IS ALREADY KNOWN ON THIS TOPICSevere mental illness has been shown to increase the risk of dementia in later life. Th...
Exploring the minimal important difference in the treatment of paediatric obsessive-compulsive disorder using selective serotonin reuptake inhibitors
BackgroundThe Children’s Yale-Brown Obsessive-Compulsive Scale (CYBOCS) is a clinician rated instrument developed to quant...
Acceptability, use and safety of the BlueIce self-harm prevention app: qualitative findings from the Beating Adolescent Self-Harm (BASH) randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICAround one in four children and young people under the age of 18 will self-harm.Most se...
Exploring early discontinuation of mental health outpatient treatment: language, demographics and clinical characteristics among migrant populations in Japan
IntroductionAs the rate of migrant population in Japan and globally is growing, so are the needs of mental health treatmen...
Prioritised research questions in serious mental illness: a priority setting based on evidence gaps
BackgroundIn 2021, the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) published a...
Brighter future for light therapy: harmonising the reporting of light interventions in psychiatry
The use of light for therapeutic purposes dates back millennia. Light therapy, as a possible treatment for seasonal affect...
Quality of melatonin use in children and adolescents: findings from a UK clinical audit
WHAT IS ALREADY KNOWN ON THIS TOPICMelatonin is commonly prescribed in UK services for children and adolescents, principal...
Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis
WHAT IS ALREADY KNOWN ON THIS TOPICTricyclic antidepressants are used to treat major depressive disorder worldwide.The Nat...
Waiting-list interventions for children and young people using child and adolescent mental health services: a systematic review
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSWaiting list interventions have the potential to support children, ...
Framework for understanding movement and physical activity in patients diagnosed with psychosis
WHAT IS ALREADY KNOWN ON THIS TOPICA recognised priority in mental healthcare is to increase physical activity and decreas...
Single session of interpretation bias modification helped to improve fear of COVID-19 and COVID-19-related post-traumatic stress symptoms
BackgroundPost-traumatic stress symptoms (PTSS) include re-experiencing the traumatic experience, avoidance of stimuli ass...
Estimating the joint association of adverse childhood experiences and asthma with subsequent depressive symptoms: a marginal structural modelling approach
WHAT IS ALREADY KNOWN ON THIS TOPICAdverse childhood experiences (ACEs) and asthma are independent risk factors for elevat...
Influence of study characteristics, methodological rigour and publication bias on efficacy of pharmacotherapy in obsessive-compulsive disorder: a systematic review and meta-analysis of randomised, placebo-controlled trials
BackgroundObsessive-compulsive disorder (OCD) is characterised by persistent thoughts, images and/or sensory perceptions t...
Are web-based stress management interventions effective as an indirect treatment for depression? An individual participant data meta-analysis of six randomised trials
WHAT IS ALREADY KNOWN ON THIS TOPICWeb-based interventions have been shown to be effective in treating depression, but upt...
All-cause and suicide mortalities among adolescents and young adults who contacted specialised gender identity services in Finland in 1996-2019: a register study
WHAT IS ALREADY KNOWN ON THIS TOPICNo previous study has examined all-cause and suicide mortalities of gender-referred ado...
Predictors of increased affective symptoms and suicidal ideation during the COVID-19 pandemic: results from a large-scale study of 14 271 Thai adults
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSDuring the COVID-19 pandemic, an increase in affective symptoms pri...
Internet-based behavioural activation therapy versus online psychoeducation for self-reported suicidal ideation in individuals with depression in Indonesia: a secondary analysis of an RCT
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionSoutheast Asia has ...
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