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Imaging endolymphatic space of the inner ear in vestibular migraine
Imaging endolymphatic space of the inner ear in vestibular migraine
WHAT IS ALREADY KNOWN ON THIS TOPICVertigo attacks in vestibular migraine (VM) and Ménière’s disease (MD) are very similar...
Long-term disability trajectories in multiple sclerosis: a group-based trajectory analysis of the AusLong cohort
Long-term disability trajectories in multiple sclerosis: a group-based trajectory analysis of the AusLong cohort
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Investigating colour vision and its structural correlates 15 years following a first demyelinating event
Investigating colour vision and its structural correlates 15 years following a first demyelinating event
IntroductionAcute optic neuritis is the initial presentation in up to 25% of people with multiple sclerosis (pwMS).1 2 The...
Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis
Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis
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MYH7-related myopathies: clinical, myopathological and genotypic spectrum in a multicentre French cohort
MYH7-related myopathies: clinical, myopathological and genotypic spectrum in a multicentre French cohort
IntroductionMyosin is the major component of the thick filament of the sarcomere structure, playing a key role in cardiac ...
Huntingtons disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration
Huntingtons disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration
IntroductionHuntington’s disease (HD) is the most common inherited adult-onset neurodegenerative disorder with a prevalenc...
Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinsons disease
Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinsons disease
IntroductionAsymmetry of motor symptoms associated with progressive asymmetric degeneration of nigral dopaminergic neurons...
Prevalence of epilepsy: a population-based cohort study in Denmark with comparison to Global Burden of Disease (GBD) prevalence estimates
Prevalence of epilepsy: a population-based cohort study in Denmark with comparison to Global Burden of Disease (GBD) prevalence estimates
IntroductionEpilepsy is a disorder of the brain characterised by an enduring predisposition to generate epileptic seizures...
Risk of fall with device-based advanced treatments in Parkinsons disease: a systematic review and network meta-analysis
Risk of fall with device-based advanced treatments in Parkinsons disease: a systematic review and network meta-analysis
BackgroundParkinson’s disease (PD) is the second most common neurodegenerative disease with a global prevalence of more th...
Cutaneous phosphorylated-synuclein: an early diagnostic biomarker for pure autonomic failure
Cutaneous phosphorylated-synuclein: an early diagnostic biomarker for pure autonomic failure
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Neural (re)organisation of language and memory: implications for neuroplasticity and cognition
Neural (re)organisation of language and memory: implications for neuroplasticity and cognition
IntroductionDue to the brain’s potential for neuroplasticity, atypical functional organisation of language and memory netw...
Code ICH: reorganising stroke care for intracerebral haemorrhage
Code ICH: reorganising stroke care for intracerebral haemorrhage
Non-traumatic intracerebral haemorrhage (ICH) remains a high mortality and morbidity disease with few single intervention ...
Highlighting the past and future of inherited peripheral neuropathies
Highlighting the past and future of inherited peripheral neuropathies
Inherited peripheral neuropathies (IPN) are among the most common inherited conditions in Neurology and are still largely ...
Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards
Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards
IntroductionInherited peripheral neuropathies (IPNs) are a group of inherited diseases affecting the peripheral nervous sy...
Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms
Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms
IntroductionThe pathogenesis of multiple sclerosis (MS) requires both environmental events and genetic factors.1–4 Conside...
Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy
Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy
IntroductionSelf-reported fatigue, a prevalent and debilitating symptom affecting up to two-thirds of people with multiple...
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
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A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI
A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI
WHAT IS ALREADY KNOWN ON THIS TOPICThere is emerging evidence that suggests accelerated intermittent theta burst stimulati...
Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales
Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales
IntroductionThe challenge of monitoring changing patterns of disease at population levels1 arises from variations in healt...
Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse
Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse
WHAT IS ALREADY KNOWN ON THIS TOPICMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) patients may ex...
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
WHAT IS ALREADY KNOWN ON THIS TOPICPlasma pTau217 is the most promising biomarker for cerebral amyloidosis and Alzheimer’s...
Exercise as medicine in Parkinsons disease
Exercise as medicine in Parkinsons disease
IntroductionParkinson’s disease (PD) is a chronic debilitating disorder of the central nervous system. It is the fastest g...
Identification of DAGLA as an autoantibody target in cerebellar ataxia
Identification of DAGLA as an autoantibody target in cerebellar ataxia
IntroductionCerebellar ataxia can be caused by different aetiologies including genetic, infectious or neurodegenerative di...
Nigrostriatal blood-brain barrier opening in Parkinsons disease
Nigrostriatal blood-brain barrier opening in Parkinsons disease
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Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
The era of modern medicine is often linked to the first clinical application of penicillin in 1943.1 How far we have come ...
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
In their JNNP meta-analysis Pozzilli et al concludes that sphingosine-1-phosphate receptor (S1PR) modulators substantially...
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
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Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial
Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial
IntroductionSafety and efficacy of an oral, fixed-dose sodium phenylbutyrate and taurursodiol combination (PB and TURSO) i...
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
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Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
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