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SCI Abstract
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Association of exercise-induced pulmonary hypertension with nailfold capillary density in systemic sclerosis: a single-center retrospective observational study
Exercise-induced pulmonary hypertension (exercise PH) is instrumental in the early detection of pulmonary arterial hyperte...
Arthritis Research & Therapy
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Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
Cadherins (CDH), such as CDH11, are glycoprotein adhesion molecules contributing to cell-cell interactions in health and d...
Arthritis Research & Therapy
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Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4)
Systemic sclerosis (SSc) is an autoimmune disease, which is characterized by fibrosis of the skin, progressing to affect t...
Arthritis Research & Therapy
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The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren’s Disease: a prospective monocentric study
To evaluate the diagnostic accuracy of salivary gland ultrasound (SGUS) in patients with high suspicion of Sjögren...
Arthritis Research & Therapy
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A 6-year prospective study on work participation and the associated factors in Dutch patients with systemic lupus erythematosus (SLE)
Previous studies showed that many patients with SLE do not have paid work. However, having paid work is important for self...
Arthritis Research & Therapy
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The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions
Currently, the pathophysiology of new bone formation in radiographic axial spondyloarthritis (r-axSpA) remains unclear. Ce...
Arthritis Research & Therapy
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis
Advances in treatment have swiftly alleviated systemic inflammation of Takayasu’s arteritis (TAK), while subclinical...
Arthritis Research & Therapy
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway
Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joint...
Arthritis Research & Therapy
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Cancer incidence and the influence of immunosuppressive agents in Korean patients with systemic lupus erythematosus: a retrospective cohort study
To investigate cancer incidence and the potential influence of immunosuppressive agents in Korean systemic lupus erythemat...
Arthritis Research & Therapy
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Machine learning prediction and explanatory models of serious infections in patients with rheumatoid arthritis treated with tofacitinib
Patients with rheumatoid arthritis (RA) have an increased risk of developing serious infections (SIs) vs. individuals with...
Arthritis Research & Therapy
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A phase 3, randomized, double-blind, active-controlled clinical trial to compare BAT1806/BIIB800, a tocilizumab biosimilar, with tocilizumab reference product in participants with moderate-to-severe rheumatoid arthritis with inadequate response to methotrexate: treatment period 2 analysis (week 24 to week 48)
Equivalent efficacy and comparable pharmacokinetic, immunogenicity, and safety profiles of the biosimilar BAT1806/BIIB800 ...
Arthritis Research & Therapy
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Early identification of macrophage activation syndrome secondary to systemic lupus erythematosus with machine learning
The macrophage activation syndrome (MAS) secondary to systemic lupus erythematosus (SLE) is a severe and life-threatening ...
Arthritis Research & Therapy
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Efficacy and safety study of targeted small-molecule drugs in the treatment of systemic lupus erythematosus
Targeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention f...
Arthritis Research & Therapy
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Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation
Exploring the pathogenesis of osteoarthritis (OA) is important for its prevention, diagnosis, and treatment. Therefore, we...
Arthritis Research & Therapy
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Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states
This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Eryth...
Arthritis Research & Therapy
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The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome
The purpose of this study was to investigate the role of macrophage polarization in the pathogenesis of primary Sjogren...
Arthritis Research & Therapy
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Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies
To classify the different clinical phenotypes and compare the distinct prognoses of microscopic polyangiitis (MPA). A retr...
Arthritis Research & Therapy
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Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization
While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolo...
Arthritis Research & Therapy
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Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia. Maintaining ...
Arthritis Research & Therapy
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Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse
Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthriti...
Arthritis Research & Therapy
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Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA). Cartilage samples were collected from OA p...
Arthritis Research & Therapy
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Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis
PANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune dis...
Arthritis Research & Therapy
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Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes
Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association stu...
Arthritis Research & Therapy
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Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progress...
Arthritis Research & Therapy
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Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation
Innate immunity plays a significant role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA), which is c...
Arthritis Research & Therapy
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The relation between synovitis of individual finger joints and grip force over the first 5 years in early rheumatoid arthritis — a cohort study
The objective of this study was to investigate the relation between swelling and tenderness of individual finger joints an...
Arthritis Research & Therapy
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Characterization of human placenta-derived exosome (pExo) as a potential osteoarthritis disease modifying therapeutic
Human placenta-derived exosomes (pExo) were generated, characterized, and evaluated as a therapeutic candidate for the tre...
Arthritis Research & Therapy
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Long-term follow-up of children with chronic non-bacterial osteomyelitis—assessment of disease activity, risk factors, and outcome
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone-disease of unknown origin. The National Pediatric Rh...
Arthritis Research & Therapy
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Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis
This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients wit...
Arthritis Research & Therapy
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Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach
Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have clustered them using machi...
Arthritis Research & Therapy
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