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Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Materials and methodsPatients and normal volunteersThis study was approved by the Biomedical Ethics Committee of Anhui Med...
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
Antibodies to citrullinated protein/peptide (ACPA) are established biomarkers for diagnosis and classification of rheumato...
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
IntroductionRheumatoid arthritis (RA) is a chronic inflammatory joint disease that affects up to 1% of the population.1 Th...
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
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Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
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Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
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EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
Overarching principles OP A: sJIA and AOSD are the same disease, that should be designated by the same unique name, Still...
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
IntroductionFor several decades, MRI has been used to investigate the early diagnosis of inflammatory sacroiliitis.1 2 How...
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
IntroductionImaging plays a pivotal role in the diagnosis and ongoing management of axial spondyloarthritis (axSpA), a con...
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
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Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz, MD, a Scientist Emeritus in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (...
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDS H. pylori infection promotes synovial cell proliferation and infla...
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICRheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) serology are impo...
Guselkumab in Behcets disease
Guselkumab in Behcets disease
The mucocutaneous and articular clinical phenotype is the most common presentation of Behçet’s disease (BD).1 Current trea...
Mystery of hidden pearls: bursitis in the shoulder
Mystery of hidden pearls: bursitis in the shoulder
A woman aged 52 years, known to have rheumatoid arthritis for 12 years, presented with worsening of joint pain for 2 weeks...
Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases
Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases
StarterRaoul Dufy received corticosteroid therapy in 1950 as one of the first patients to be treated with cortisone to rel...
Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases
Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disorder characteristic by excessive ...
Systemic juvenile idiopathic arthritis and adult-onset Stills disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Stills disease
Systemic juvenile idiopathic arthritis and adult-onset Stills disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Stills disease
IntroductionStill’s disease was described in children in 1897 by Sir George Frederick Still and is today called systemic j...
Efficacy and safety of therapies for Stills disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Stills disease
Efficacy and safety of therapies for Stills disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Stills disease
IntroductionAdult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) are the adult and child c...
Plasma proteome profiling in giant cell arteritis
Plasma proteome profiling in giant cell arteritis
IntroductionEarly in its disease course, giant cell arteritis (GCA) can cause irreversible vision loss and cerebrovascular...
Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease
Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease
IntroductionBoth rheumatic musculoskeletal diseases (RMDs) and cancer occur frequently in the general population and these...
Expression of HIF1{alpha} in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
Expression of HIF1{alpha} in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
WHAT IS KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis study shows that the death of intestinal epithelial cells via necropto...
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
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Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study
Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study
IntroductionSerological activity in systemic lupus erythematosus (SLE) generally refers to the presence of anti-dsDNA anti...
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
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Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
IntroductionSystemic lupus erythematosus (SLE) is a complex autoimmune disease in which patients experience diverse organ ...
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
IntroductionOsteoarthritis is a highly complex disease that poses a significant burden on both individuals and society due...
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögrens disease
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögrens disease
AbstractObjectives Inflammatory cytokines that signal through the Janus kinases–signal transducer and activator of transcr...
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
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Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
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