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Novel bifunctional antibacterial peptides mediated by a covalent conjugation strategy combat priority multidrug-resistant gram-negative pathogens through dual targets
Novel bifunctional antibacterial peptides mediated by a covalent conjugation strategy combat priority multidrug-resistant gram-negative pathogens through dual targets
The escalating antibiotic resistance presents formidable challenges in the treatment of Gram-negative bacterial infections...
New dimeric 5-hydroxy-2-hexenoic acid isolated from culture broth of Clonostachys rogersoniana
New dimeric 5-hydroxy-2-hexenoic acid isolated from culture broth of Clonostachys rogersoniana
A new dimeric 5-hydroxy-2-hexenoic acid, clonohexenoic acid (1), a known 14-membered macrolide, acremodiol B (2), and two ...
Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model
Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model
Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than thos...
In vitro synergistic effect and mutant prevention concentration of eravacycline alone or in combination with various antibiotics against OXA-48 producing enterobacterales
In vitro synergistic effect and mutant prevention concentration of eravacycline alone or in combination with various antibiotics against OXA-48 producing enterobacterales
This study examines the effects of combining eravacycline with various antibiotics on carbapenem-resistant Enterobacterale...
Contezolid, a novel oxazolidinone antibiotic, acts as a potential anti-inflammatory agent
Contezolid, a novel oxazolidinone antibiotic, acts as a potential anti-inflammatory agent
Contezolid, a novel oxazolidinone antibiotic, has comparable or superior antibacterial efficacy and safety to linezolid, n...
Antibacterial properties of quaternized cellulose nanocrystals in clinical isolates of multidrug-resistant gram-negative bacteria
Antibacterial properties of quaternized cellulose nanocrystals in clinical isolates of multidrug-resistant gram-negative bacteria
Gram-negative bacterial pathogens are responsible for various infections. Over the past decade, these pathogens have acqui...
Unlocking hidden bioactive compounds: from indolocarbazole and RiPP biosynthesis to the activation of cryptic secondary metabolism via microbial interactions
Unlocking hidden bioactive compounds: from indolocarbazole and RiPP biosynthesis to the activation of cryptic secondary metabolism via microbial interactions
Actinomycetes, particularly Streptomyces, are soil microorganisms that produce diverse secondary metabolites with pharmace...
Isolation and synthesis of a new cyclic tetrapeptide from marine-associated Bacillus sp. and its bacterial biofilm formation inhibitory activity
Isolation and synthesis of a new cyclic tetrapeptide from marine-associated Bacillus sp. and its bacterial biofilm formation inhibitory activity
A new cyclic tetrapeptide named Cereusitin B (1), along with a number of known cyclic dipeptides was isolated from the fer...
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2–5) were isolated from a c...
Correction: Synthesis and antibacterial action of 3’,6’-disubstituted spectinomycins
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Exploration of vanoxerine analogues as antibacterial agents
Exploration of vanoxerine analogues as antibacterial agents
Mycobacterium tuberculosis is a bacterial pathogen, responsible for approximately 1.3 million deaths in 2022 through tuber...
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes
Linezolid binds to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis by preventing the for...
Streptomyces yaizuensis sp. nov., a berninamycin C-producing actinomycete isolated from sponge
Streptomyces yaizuensis sp. nov., a berninamycin C-producing actinomycete isolated from sponge
While screening for antibiotics in a marine sample, we discovered a berninamycin C-producing actinomycete, designated YSPA...
Sinulariapeptide F, a new peptide from culture broth of marine-derived fungus Simplicillium sp. SCSIO 41222
Sinulariapeptide F, a new peptide from culture broth of marine-derived fungus Simplicillium sp. SCSIO 41222
One new compound named sinulariapeptide F (1) together with one known butyrolactone (2) and seven known peptides (3–...
Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6
Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6
A new bioactive substance was identified from a leaf-litter actinomycete strain by screening for antibacterial activity ag...
Antimicrobial activity of α/β hybrid peptides incorporating tBu-β3,3Ac6c against methicillin-resistant Staphylococcus aureus
Antimicrobial activity of α/β hybrid peptides incorporating tBu-β3,3Ac6c against methicillin-resistant Staphylococcus aureus
The incorporation of β-amino acids into peptides is a promising approach to develop proteolytically stable therapeuti...
Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from ...
Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases
Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases
Waldiomycin is an inhibitor of histidine kinases (HKs). Although most HK inhibitors target the ATP-binding region, waldiom...
Identification of novel antistaphylococcal hit compounds
Identification of novel antistaphylococcal hit compounds
Staphylococcus aureus is one of the most common nosocomial biofilm-forming pathogens worldwide that has developed resistan...
Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Two new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP21...
Actinoplanes kirromycinicus sp. nov., isolated from soil
Actinoplanes kirromycinicus sp. nov., isolated from soil
A novel actinomycete, designated as TPMA0078T, was isolated from a soil sample collected in Shinjuku, Tokyo, Japan. 16S rR...
Minimum inhibitory concentrations of aztreonam–avibactam, ceftazidime–avibactam and meropenem in clinical isolates of Klebsiella pneumoniae harboring carbapenemase genes
This study was aimed at understanding the distributions of the MICs (minimum inhibitory concentrations) of aztreonam–...
Repurposing of dibucaine and niflumic acid as antimicrobial agents in combination with antibiotics against Staphylococcus aureus
Repurposing of dibucaine and niflumic acid as antimicrobial agents in combination with antibiotics against Staphylococcus aureus
The versatile human commensal bacteria and pathogen Staphylococcus aureus cause several community and hospital-acquired il...
Herbidomicins, two pairs of polyketide tautomers produced by an actinomycete of the genus Herbidospora
Herbidomicins, two pairs of polyketide tautomers produced by an actinomycete of the genus Herbidospora
Herbidospora is one of the underexplored actinomycete genera from which only a limited number of secondary metabolites are...
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Ten new proansamycin B congeners (1–10) together with one known (11) were isolated and characterized on the basis of...
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured mate...
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors
The multidrug-resistant clone identified as Escherichia coli sequence type 131 (E. coli ST131) has spread world-wide. This...
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
Antimicrobial resistance is a global health problem. In 2021, it was estimated almost half a million of multidrug-resistan...
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized bec...
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is respons...
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