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Advancement of artificial intelligence based treatment strategy in type 2 diabetes: A critical update
In the unrelenting race to strive to dominate type 2 diabetes mellitus (T2DM) care better, this review paper sets out on a...
Targeted Reduction-Responsive Nanovehicles for Photodynamic Therapy-Primed Immunotherapy in Melanoma
Melanoma, a common malignant skin tumor, faces challenges with multidrug resistance and high recurrence rates. Combining p...
Metabolomics-driven elucidation of the synergistic therapeutic mechanism of a novel SGLT-2/PPAR-γ dual receptor supramolecular system for treatment diabetes and obesity
Available online 12 April 2025, 101308Author links open overlay panel, , , , , Highlights•A novel SGLT-2/PPAR-γ dual recep...
Oblique-incidence Reflectivity Difference Technology Identifies the Antiviral Drug Ribavirin as an Inhibitor of Lung Tumor Progression by Targeting AMPK Signaling
Lung cancer takes the lead in terms of global cancer incidence and mortality rates. 5'-Adenosine monophosphate (AMP)-activ...
α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation
Available online 12 April 2025, 101301Author links open overlay panel, , , , , , , , Highlights•SNX10 knockdown promotes D...
Virulence arresting drugs discovery by strategies targeting bacterial virulence: mainly focusing on quorum-sensing interference and biofilm inhibition
The rising prevalence of multidrug-resistant pathogens poses a substantial threat to global healthcare systems, demanding ...
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro
Vascular endothelial senescence is an important pathophysiological factor in the development and exacerbation of cardiovas...
Advancements in plant-derived exosome-like vesicles: Versatile bioactive carriers for targeted drug delivery systems
Available online 14 April 2025, 101300Author links open overlay panel, , , , , Highlights•Plant-derived exosomes are less ...
Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide
Available online 14 April 2025, 101309Author links open overlay panel, , , , , , , , , , Highlights•Targeting the activate...
Targeting Atf4 for enhanced neuroprotection: Role of quercetin-loaded evs in ischemic stroke
Available online 16 April 2025, 101312Author links open overlay panel, , , , Highlights•The study is the first to report t...
A Multimodal Contrastive Learning Framework for Predicting P-Glycoprotein Substrates and Inhibitors
P-glycoprotein (P-gp) is a transmembrane protein widely involved in the absorption, distribution, metabolism, excretion, a...
ACtriplet: An improved deep learning model for activity cliffs prediction by integrating triplet loss and pre-training
Activity cliffs (ACs) are generally defined as pairs of similar compounds that only differ by a minor structural modificat...
SITA: Predicting Site-specific Immunogenicity for Therapeutic Antibodies
Antibody (Ab) humanization is critical to reduce immunogenicity and enhance efficacy in the preclinical phase of the devel...
DTLCDR: A target-based multimodal fusion deep learning framework for cancer drug response prediction
Available online 21 April 2025, 101315Author links open overlay panel, , , , , , Highlights:•DTLCDR is constructed to pred...
Chemical Analysis, Antihyperglycemic Properties and Enzyme Inhibition of Opuntia dillenii (Ker Gawl.) Haw: A Detailed Analysis of Pulp and Peel Extracts
Opuntia dillenii (Ker Gawl.) Haw, which has long been prized for its therapeutic virtues, has shown promise in treating hy...
Decoding protein dynamics with limited proteolysis coupled to mass spectrometry: A comprehensive review
Available online 21 April 2025, 101319Author links open overlay panel, , , Highlights:•This review provides a comprehensiv...
Unlocking the potential of atractylenolide II: mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay
Available online 21 April 2025, 101318Author links open overlay panel, , , , , , , Highlights•FXR activation inhibits hepa...
In Vivo Analysis Techniques for Antibody Drug: Recent Advances and Methodological Insights
Antibody drugs, such as monoclonal antibodies and antibody-drug conjugates, have shown significant potential in treating d...
Identification of forsythoside A from Forsythia fruit for alleviating MAFLD via metabolic remodeling and IL-17 pathway regulation
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
From foe to friend: Rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor
Available online 25 April 2025, 101322Author links open overlay panel, , , , Highlights•Reprogram MDM2-HSC70 axis triggers...
miR-135b: An emerging player in cardio-cerebrovascular diseases
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Epigenetic regulation of targeted ferroptosis: A new strategy for drug development
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“Small is beautiful” – Examining reliable determination of low-abundant therapeutic antibody glycovariants
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Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC
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Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy
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Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC/IM-QTOF-MS and an in-house high-definition MS2 library: Sishen formula as a case
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Optical biosensing of monkeypox virus using novel recombinant silica-binding proteins for site-directed antibody immobilization
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Cirsium japonicum mitigates allergic nasal inflammation by regulating NRF2-mediated mucin production: Systematic transcriptome and molecular docking analyses
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Multidimensional screening of Astragalus membranaceus small molecules to mitigate carbon ion radiation-induced bystander effects
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Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods
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