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Combination of S-1 and the oral ATR inhibitor ceralasertib is effective against pancreatic cancer cells
Combination of S-1 and the oral ATR inhibitor ceralasertib is effective against pancreatic cancer cells
In our previous study, we found that the Chk1 inhibitor prexasertib enhances the antitumour effect of the oral anticancer ...
Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination
Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination
High-dose methotrexate (HDMTX) therapy is an important component in treatment regimens for acute lymphoblastic leukemia (A...
Phase I–II study of OBI-888, a humanized monoclonal IgG1 antibody against the tumor-associated carbohydrate antigen Globo H, in patients with advanced solid tumors
Phase I–II study of OBI-888, a humanized monoclonal IgG1 antibody against the tumor-associated carbohydrate antigen Globo H, in patients with advanced solid tumors
OBI-888 is a humanized, monoclonal IgG1 antibody specific to the tumor-associated carbohydrate antigen Globo H. We conduct...
Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury
Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury
Neratinib, a small-molecule tyrosine kinase inhibitor (TKI) that irreversibly binds to human epidermal growth factor recep...
Population pharmacokinetic and exposure-toxicity analyses of nab-paclitaxel after pegylated recombinant human granulocyte colony-stimulating factor administration in patients with metastatic breast cancer
Population pharmacokinetic and exposure-toxicity analyses of nab-paclitaxel after pegylated recombinant human granulocyte colony-stimulating factor administration in patients with metastatic breast cancer
This study aimed to establish a population pharmacokinetic (PK) model to evaluate the dynamic relationship between the con...
Acute kidney injury in a child treated with cisplatin and amphotericin B
Acute kidney injury in a child treated with cisplatin and amphotericin B
Cisplatin and amphotericin B are both known to be potentially nephrotoxic. We describe acute kidney injury due to the comb...
Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma
Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies. Our previous work revealed Chitinase 3-...
Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19
Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19
A physiologically based pharmacokinetic (PBPK) model for fedratinib was updated and revalidated to bridge a gap between th...
Pharmacogenomic associations of cyclophosphamide pharmacokinetic candidate genes with 4hydroxycyclophosphamide formation in children with Cancer
Pharmacogenomic associations of cyclophosphamide pharmacokinetic candidate genes with 4hydroxycyclophosphamide formation in children with Cancer
4-hydroxycyclophosphamide (4HCY) is the principal precursor to the cytotoxic metabolite of cyclophosphamide (CY), which is...
Low serum concentrations of bevacizumab and nivolumab owing to excessive urinary loss in patients with proteinuria: a case series
Low serum concentrations of bevacizumab and nivolumab owing to excessive urinary loss in patients with proteinuria: a case series
Proteinuria can cause interindividual variability in the pharmacokinetics of therapeutic antibodies and may affect therape...
Successful use of Palbociclib combined with Venetoclax and Azacitidine in an adult with refractory/relapsed therapy-related acute myeloid leukemia
Successful use of Palbociclib combined with Venetoclax and Azacitidine in an adult with refractory/relapsed therapy-related acute myeloid leukemia
Therapy-related acute myeloid leukemia (t-AML) is considered high risk as it related to prior exposure to cytotoxic chemot...
Continuous exposure to doxorubicin induces stem cell-like characteristics and plasticity in MDA-MB-231 breast cancer cells identified with the SORE6 reporter
Continuous exposure to doxorubicin induces stem cell-like characteristics and plasticity in MDA-MB-231 breast cancer cells identified with the SORE6 reporter
Cancer stem cells (CSCs) account for recurrence and resistance to breast cancer drugs, rendering them a cause of mortality...
Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2
Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2
Hair cell damage is a common side effect caused by the anticancer drug cisplatin (CDDP), which reduces patient quality of ...
The Gustave Roussy Immune score is a powerful biomarker for predicting therapeutic resistance to chemotherapy in gastric cancer patients
The Gustave Roussy Immune score is a powerful biomarker for predicting therapeutic resistance to chemotherapy in gastric cancer patients
It is highly important to be able to predict the therapeutic efficacy of chemotherapy on patients with unresectable advanc...
Pharmacokinetic and bioequivalence study of two capecitabine tablets in Chinese patients with solid tumor cancer
Pharmacokinetic and bioequivalence study of two capecitabine tablets in Chinese patients with solid tumor cancer
Capecitabine (CAP) is one of the fluoropyrimidine deoxynucleoside carbamates, which can be converted to 5-fluorouracil (5-...
Effect of midostaurin on the pharmacokinetics of P-gp, BCRP, and CYP2D6 substrates: assessing potential drug-drug interactions in healthy participants
Effect of midostaurin on the pharmacokinetics of P-gp, BCRP, and CYP2D6 substrates: assessing potential drug-drug interactions in healthy participants
Midostaurin, approved for FLT3-mutated acute myeloid leukemia and advanced systemic mastocytosis, is mainly metabolized by...
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway
Osteosarcoma is the most common malignant bone tumor in children and adolescents. Conventional chemotherapy remains unsati...
A comparison of the renal function biomarkers serum creatinine, pro-enkephalin and cystatin C to predict clearance of pemetrexed
A comparison of the renal function biomarkers serum creatinine, pro-enkephalin and cystatin C to predict clearance of pemetrexed
For drugs with a narrow therapeutic window, there is a delicate balance between efficacy and toxicity, thus it is pivotal ...
Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer
Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer
Ovarian cancer is a malignant tumor of the female reproductive system, and its mortality rate is as high as 70%. Estrogen ...
Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice
Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice
The Ataxia Telangiectasia and Rad3-related (ATR) protein complex is an apical initiator of DNA damage response pathways. S...
Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children
Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children
Model-based methods can predict pediatric exposure and support initial dose selection. The aim of this study was to evalua...
Overexposure to venetoclax is associated with prolonged-duration of neutropenia during venetoclax and azacitidine therapy in Japanese patients with acute myeloid leukemia
Overexposure to venetoclax is associated with prolonged-duration of neutropenia during venetoclax and azacitidine therapy in Japanese patients with acute myeloid leukemia
An observational study was conducted to evaluate the pharmacokinetics of venetoclax and its impact on the efficacy and saf...
Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221
Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221
Chemotherapy-induced peripheral neuropathy (CIPN) is a treatment-limiting and debilitating neurotoxicity of many commonly ...
Oral docetaxel plus encequidar – a phase 1 clinical trial
Oral docetaxel plus encequidar – a phase 1 clinical trial
To determine the bioavailability, safety, and tolerability of a single dose of oral docetaxel plus encequidar (oDox ...
Evaluation of mycophenolic acid exposure in a patient with immune-related hepatotoxicity caused by nivolumab and ipilimumab therapy for malignant melanoma: a case report
Evaluation of mycophenolic acid exposure in a patient with immune-related hepatotoxicity caused by nivolumab and ipilimumab therapy for malignant melanoma: a case report
Guidelines such as the National Comprehensive Cancer Network recommend mycophenolate mofetil (MMF) for the treatment of se...
Machine learning application identifies plasma markers for proteinuria in metastatic colorectal cancer patients treated with Bevacizumab
Machine learning application identifies plasma markers for proteinuria in metastatic colorectal cancer patients treated with Bevacizumab
Proteinuria is a common complication after the application of bevacizumab therapy in patients with metastatic colorectal c...
18β-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis
18β-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis
18β-glycyrrhetinic acid (GA), the main metabolite of glycyrrhizic acid extracted from the root of licorice, has been ...
Using maximum plasma concentration (Cmax) to personalize taxane treatment and reduce toxicity
Using maximum plasma concentration (Cmax) to personalize taxane treatment and reduce toxicity
Taxanes are a widely used class of anticancer agents that play a vital role in the treatment of a variety of cancers. Howe...
Ommaya reservoir use in pediatric ALL and NHL: a review at St. Jude Children’s Research Hospital
Ommaya reservoir use in pediatric ALL and NHL: a review at St. Jude Children’s Research Hospital
The intraventricular route of chemotherapy administration, via an Ommaya Reservoir (OmR) improves drug distribution in the...
A first-in-human phase I study of TAS-117, an allosteric AKT inhibitor, in patients with advanced solid tumors
A first-in-human phase I study of TAS-117, an allosteric AKT inhibitor, in patients with advanced solid tumors
TAS-117 is a highly potent and selective, oral, allosteric pan-AKT inhibitor under development for advanced/metastatic sol...
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