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Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Urine alkalinization prevents nephrotoxicity in patients receiving high-dose methotrexate (HDMTX). While the standard appr...
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Myocardial ischemia/reperfusion injury (MIRI) seriously threatens the health of people. The mitochondrial dysfunction in c...
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regu...
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
The efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction betw...
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin
It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome ...
Public interest in drug-related problems reflected in information search trends: an infodemiological study
Public interest in drug-related problems reflected in information search trends: an infodemiological study
The analysis of how people search and “navigate” the internet to obtain health-related information and how the...
Repurposing metformin as a potential anticancer agent using in silico technique
Repurposing metformin as a potential anticancer agent using in silico technique
The focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medicatio...
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Sometimes clinical efficacy and potential risk of therapeutic and toxic agents are difficult to predict over a long period...
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles
Patients with cystic fibrosis commonly suffer from lung infections caused by Pseudomonas aeruginosa. Recently, the Levoflo...
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
Melanoma poses a significant threat to human health, making the development of a safe and effective treatment a crucial ch...
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
Several countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (N...
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication
COVID-19 pandemic has turned our world upside down by meddling with our normal lives. While there is no definitive drug ag...
Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study
Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study
Multiple Sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease of the CNS. Riluzole and dimethyl fumar...
Dispersive micro-solid phase extraction based on two MOFs as highly effective adsorbents for analysis of nilotinib in plasma and wastewater
Dispersive micro-solid phase extraction based on two MOFs as highly effective adsorbents for analysis of nilotinib in plasma and wastewater
Nilotinib (NIL) is a prescription medication employed in the treatment of specific types of leukemia, namely chronic myelo...
Population Pharmacokinetics of Loxoprofen and its alcoholic metabolites in healthy Korean men
Population Pharmacokinetics of Loxoprofen and its alcoholic metabolites in healthy Korean men
Loxoprofen has been actively used clinically to relieve musculoskeletal pain and inflammatory symptoms. However, there are...
A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure–Activity Relationship (SAR) of coumarins
A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure–Activity Relationship (SAR) of coumarins
The Ferluago W.D.J. Koch genus includes 48 accepted perennial herbs that are distributed in the Mediterranean region, Sout...
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Alzheimer’s disease (AD) is a neurological disease that causes memory loss over time. Current therapies are limited ...
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an e...
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar is one of the most famous fruit byproducts worldwide with several unique properties. There are two types of ...
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Nivolumab is used in a treatment called immunotherapy, which helps the immune system cells to attack cancer cells. The ele...
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Renal cell carcinoma (RCC) is a common malignancy. Local anesthetics were displayed powerful effects against various cance...
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
Typical antipsychotics are known to produce extrapyramidal side effects such as drug induced parkinsonism, acute dystonia,...
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury
Dexamethasone-induced neurotoxicity has been previously reported. However, the molecular mechanisms are still not complete...
Towards greater impact in health technology assessment: System dynamic approach for new and emerging technologies in Iran
Towards greater impact in health technology assessment: System dynamic approach for new and emerging technologies in Iran
As classical health technology assessment models fail to predict the complexities of related impacts, the application of m...
Immediate hypersensitivity reaction to levetiracetam: a case report study
Immediate hypersensitivity reaction to levetiracetam: a case report study
Anticonvulsant drugs are one of the most common causes of delayed hypersensitivity reactions, such as drug reacti...
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
Acute myeloid leukemia (AML) is a hematopoietic malignancy. Chidamide has shown anti-cancer effect in different malignanci...
Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
Diabetes Mellitus (DM) is a prominent health care issue worldwide. One of the most prevalent comorbidities of DM is cardio...
Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
Colloid and/or co-load may be more effective than crystalloid for preventing postspinal anesthesia hypotension. We tested ...
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Several studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogen...
Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies
Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies
Gastric cancer (GC) is known as the fourth leading cause of cancer-related death and the fifth major cancer in the world, ...
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