Koch-Weser J, Metoprolol. N Eng J Med. 1979;30:698–703. https://doi.org/10.1056/NEJM197909273011306.
Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138:103–41. https://doi.org/10.1016/j.pharmthera.2012.12.007.
Article CAS PubMed Google Scholar
Nagele P, Liggett SB, Warner DS. Genetic variation, β-blockers, and perioperative myocardial infarction. Anesthesiology. 2011;115:1316–27. https://doi.org/10.1097/ALN.0b013e3182315eb2.
Article CAS PubMed Google Scholar
Rau T, Wuttke H, Michels L, et al. Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study. Clin Pharmacol Ther. 2009;85:269–72. https://doi.org/10.1038/clpt.2008.218.
Article CAS PubMed Google Scholar
Laurent-Kenesi MA, Funck‐Brentano C, Poirier JM, Decolin D, Jaillon P. Influence of CYP2D6‐dependent metabolism on the steady‐state pharmacokinetics and pharmacodynamics of metoprolol and nicardipine, alone and in combination. Br J Clin Pharmacol. 1993;36:531–38. https://doi.org/10.1111/j.1365-2125.1993.tb00411.x.
Article CAS PubMed PubMed Central Google Scholar
Cerqueira PM, Cesarino EJ, Mateus FH, et al. Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients. Chirality. 1999;11:591–97. https://doi.org/10.1002/(SICI)1520-636X(1999)11:7%3C;591::AID-CHIR12%3E;3.0.CO;2-T.
Balmér K, Persson A, Lagerström P-O, Persson B-A, Schill G. Liquid chromatographic separation of the enantiomers of metoprolol and its α-hydroxy metabolite on chiralcel OD for determination in plasma and urine. J Chromatogr A. 1991;553:391–97. https://doi.org/10.1016/S0021-9673(01)88509-5.
Johnson JA, Burlew BS. Metoprolol metabolism via cytochrome P4502D6 in ethnic populations. Drug Metab Dispos. 1996;24:350–55. https://doi.org/10.1016/S0090-9556(25)07354-4.
Article CAS PubMed Google Scholar
Jonkers RE, Koopmans RP, Portier E, van Boxtel CJ. Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers. J Pharmacol Exp Ther. 1991;256:959–66. https://doi.org/10.1016/S0022-3565(25)23095-6.
Article CAS PubMed Google Scholar
Lennard M, Tucker G, Silas J, et al. Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers. Clin Pharmacol Ther. 1983;34:732–37. https://doi.org/10.1038/clpt.1983.242.
Article CAS PubMed Google Scholar
Andersson T, Lundborg P, Regårdh CG. Lack of effect of omeprazole treatment on steady-state plasma levels of metoprolol. Eur J Clin Pharmacol. 1991;40:61–5. https://doi.org/10.1007/BF00315140.
Article CAS PubMed Google Scholar
Mautz DS, Nelson WL, Shen DD. Regioselective and stereoselective oxidation of metoprolol and bufuralol catalyzed by microsomes containing cDNA-expressed human P4502D6. Drug Metab Dispos. 1995;23:513–17. https://doi.org/10.1016/S0090-9556(25)06590-0.
Article CAS PubMed Google Scholar
Otton S, Crewe H, Lennard M, Tucker G, Woods H. Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes. J Pharmacol Exp Ther. 1988;247:242–47. https://doi.org/10.1016/S0022-3565(25)20010-6.
Article CAS PubMed Google Scholar
Leemann T, Devi K, Dayer P. Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (±)-metoprolol. Eur J Clin Pharmacol. 1993;45:65–71. https://doi.org/10.1007/BF00315352.
Article CAS PubMed Google Scholar
Cerqueira PM, Coelho EB, Geleilete TJM, Goldman GH, Lanchote VL. Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients. J Clin Pharmacol. 2005;45:1422–33. https://doi.org/10.1177/0091270005281816.
Article CAS PubMed Google Scholar
Murthy SS, Shetty HU, Nelson WL, Lennard MS. Enantioselective and diastereoselective aspects of the oxidative metabolism of metoprolol. Biochem Pharmacol. 1990;40:1637–44. https://doi.org/10.1016/0006-2952(90)90466-X.
Article CAS PubMed Google Scholar
Kim KH, Kim HJ, Kang J-S, Mar W. Determination of metoprolol enantiomers in human urine by coupled achiral–chiral chromatography. J Pharm Biomed Anal. 2000;22:377–84. https://doi.org/10.1016/S0731-7085(99)00279-4.
Article CAS PubMed Google Scholar
Lim H-K, Linh PT, Hong C-H, Kim K-H, Kang J-S. Enantioselective determination of metoprolol and major metabolites in human urine by capillary electrophoresis. J Chromatogr B Biomed Sci. 2001;755:259–64. https://doi.org/10.1016/S0378-4347(01)00118-9.
Pflugmann G, Spahn H, Mutschler E. Rapid determination of the enantiomers of metoprolol, oxprenolol and propranolol in urine. J Chromatogr B Biomed Sci. 1987;416:331–39. https://doi.org/10.1016/0378-4347(87)80516-9.
Baranowska I, Adolf W, Magiera S. Enantioselective determination of Metoprolol and its metabolites in human urine high-performance liquid chromatography with fluorescence detection (HPLC–FLD) and tandem mass spectrometry (MS/MS). J Chromatogr B. 2015;1004:79–84. https://doi.org/10.1016/j.jchromb.2015.09.019.
Kim K, Lee J, Ko M, et al. Determination of metoprolol enantiomers in human urine by GC-MS using (–)-α-methoxy-α-(trifluoromethyl) phenylacetyl chloride as a chiral derivatizing agent. Chromatographia. 2002;55:81–5. https://doi.org/10.1007/BF02492319.
Yu T, Du Y, Chen B. Evaluation of clarithromycin lactobionate as a novel chiral selector for enantiomeric separation of basic drugs in capillary electrophoresis. Electrophoresis. 2011;32:1898–905. https://doi.org/10.1002/elps.201000630.
Article CAS PubMed Google Scholar
Lebedeva MV, Prokhorova AF, Shapovalova EN, Shpigun OA. Clarithromycin as a chiral selector for enantioseparation of basic compounds in nonaqueous capillary electrophoresis. Electrophoresis. 2014;35:2759–64. https://doi.org/10.1002/elps.201400135.
Article CAS PubMed Google Scholar
Acree Jr. W.E. Impact of automation on Immunoanalysis testing. Immunoanalysis. 2023;3:12. https://doi.org/10.34172/ia.2023.12.
Chien R-L, Burgi DS. Field amplified sample injection in high-performance capillary electrophoresis. J Chromatogr A. 1991;559:141 − 52. https://doi.org/10.1016/0021-9673(91)80066-P
Jouyban K, Dehpour AR, Seyfinejad B, Jouyban A. Metoprolol metabolites’ ratios and/or enantiomeric profiles: a simple and low-cost tool for personalized medicine through CYP2D6 phenotyping. Pharm Sci. 2025;31:1–2. https://doi.org/10.34172/PS.024.40525.
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