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Cerebrovascular protective functions of amyloid precursor protein: Progress and therapeutic prospects
Available online 5 September 2025, 108921Author links open overlay panel, , AbstractUnder physiological conditions, amyloi...
Hydroxyl carboxylic acid receptor-2 (HCAR2) as a potential target in neurometabolic diseases
KeywordsHydroxyl carboxylic acid receptor-2Β-HydroxybutyrateNeuroinflammationNeurometabolic dysfunctionsChronic painNeurod...
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments
5-HT1AR/5-HT1BR/5-HT2AR/5-HT2BRserotonin receptors type 1A, 1B, 2A, 2BA2ARadenosine receptor type 2AACKR3atypical chemokin...
Macrophages at the crossroads of cellular senescence and cancer development and progression: Therapeutic opportunities and challenges
Macrophages are highly adaptable immune cells that play critical roles in various biological processes, including immune r...
The role of lysine acetylation in metabolic sensing and proteostasis
Post-translational modifications (PTMs) are the essential regulators of protein function and cellular homeostasis. Lysine ...
Human PSC-derived liver cells and their applications for disease models and drug discovery
AcLDLacetylated low-density lipoproteinALCAMactivated leukocyte cell adhesion moleculeAHRAryl hydrocarbon receptorASBTApic...
Neutrophil Extracellular Traps (NETs) as drivers of atherosclerosis: Pathogenic mechanisms and therapeutic opportunities
Cardiovascular diseases (CVDs) are the leading cause of death globally. The primary pathological process underlying CVDs i...
Therapeutic exploration of biased ligands at class A G protein-coupled receptors over the past 20 years
G protein-coupled receptors (GPCRs) represent the largest family of membrane proteins within the human genome, comprising ...
Suppressor tRNAs as personalized therapy for nonsense mutation-associated pathologies
Nonsense mutations – associated with many devastating genetic disorders that currently lack effective treatments – prematu...
Air pollution and diseases: signaling, G protein-coupled and Toll like receptors
It is well recognized that air pollution is a major public health issue with direct impact on lung health. The source of a...
Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow
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Cannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery
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Roles of NLRC4 inflammasome in neurological disorders: Mechanisms, implications, and therapeutic potential
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Semaphorin 3s signaling in the central nervous system: Mechanisms and therapeutic implication for brain diseases
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Peripheral GABAA receptors - Physiological relevance and therapeutic implications
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Signaling pathways and targeted therapies in Ewing sarcoma
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Uncovering the intricacies of O-GlcNAc modification in cognitive impairment: New insights from regulation to therapeutic targeting
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Is there a place for natural agents with anti-inflammatory and antioxidative properties in critically ill patients? Potential usefulness of Xanthohumol
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Combinational CAR T-cell therapy for solid tumors: Requisites, rationales, and trials
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Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy
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EGFL7: An emerging biomarker with great therapeutic potential
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Glucuronidation of orally administered drugs and the value of nanocarriers in strategies for its overcome
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Non-vesicular extracellular RNA: A potential drug target to intervene cell-cell communication
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Probiotic supplement for the treatment of polycystic ovarian syndrome
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Essential role of sulfide oxidation in brain health and neurological disorders
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Non-canonical signaling initiated by hormone-responsive G protein-coupled receptors from subcellular compartments
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Biased signaling in GPCRs: Structural insights and implications for drug development
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Biased agonism at free-fatty acid receptor-4 (FFA4/GPR120)
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G protein-coupled purinergic P2Y receptors in infectious diseases
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CircRNAs as upstream regulators of miRNA//HMGA2 axis in human cancer
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