Human PSC-derived liver cells and their applications for disease models and drug discovery

AcLDL

acetylated low-density lipoprotein

ALCAM

activated leukocyte cell adhesion molecule

AHR

Aryl hydrocarbon receptor

ASBT

Apical sodium-dependent bile acid transporter

αSMA

α-smooth muscle actin

BMP

bone morphogenetic protein

CFTR

Cystic fibrosis transmembrane conductance regulator

COL1A1

type I collagen alpha 1 chain

CPs

cholangiocyte progenitors

CYP1A1

cytochrome P450 1A1

Fah

Fumarylacetoacetate hydrolase

FCGR2B

Fc gamma receptor IIb

FGF

fibroblast growth factor

FLT4

fms related receptor tyrosine kinase 4

GFAP

glial fibrillary acidic protein

GGT

gamma-glutamyl transferase

HBOs

hepatobiliary organoids

HGF

hepatocyte growth factor

HLCs

hepatocyte-like cells

HNF4α

hepatocyte nuclear factor 4 alpha

HSCs

hepatic stellate cells

hPSCs

human pluripotent stem cells

Il2rg

Interleukin 2 Receptor Subunit Gamma

KDR

Kinase insert domain receptor

Klf4

Kruppel-like factor 4

LC-MS/MS

Liquid chromatography/Mass spectrometry

LRAT

lecithin retinol acyltransferase

LSECs

liver sinusoidal endothelial cells

LPCs

liver progenitor cells

LYVE1

lymphatic vessel endothelial hyaluronan receptor 1

MASH

metabolic dysfunction-associated steatohepatitis

NASH

non-alcoholic steatohepatitis

NCAM

neural cell adhesion molecule

NGFR

nerve growth factor receptor

PDGF

Platelet-derived growth factor

PDX1

Pancreatic and duodenal homeobox 1

PHHs

primary human hepatocytes

PSCs

pluripotent stem cells

Rag2

Recombination activating gene 2

ROCK

Rho-associated protein kinase

SOX

SRY-box transcription factor

TGFβ

transforming growth factor beta

TGFβRI

transforming growth factor beta receptor 1

TIMP-1

Tissue inhibitor of metallopeptidase-1

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