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Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review
Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review
Schizophrenia is a severe neuropsychiatric disorder ranking among the top ten global disability causes. In rodents, sub-ch...
Prolonged administration of letrozole induces polycystic ovary syndrome leading to osteoporosis in rats: model development and validation studies
Prolonged administration of letrozole induces polycystic ovary syndrome leading to osteoporosis in rats: model development and validation studies
Polycystic ovary syndrome (PCOS) mainly affects women of reproductive age. Clinical studies suggest a link between PCOS an...
Cinobufagin: Unveiling the hidden bufadienolide’s promise in combating alimentary canal cancer development and progression – a comprehensive review
Cinobufagin: Unveiling the hidden bufadienolide’s promise in combating alimentary canal cancer development and progression – a comprehensive review
Cinobufagin (CB) is a bufadienolide extracted from the parotid gland of frogs. This compound is a Na + /K̴...
Quinic acid alleviates liver toxicity induced by acetaminophen in mice via anti-oxidative and anti-inflammatory effects
Quinic acid alleviates liver toxicity induced by acetaminophen in mice via anti-oxidative and anti-inflammatory effects
Acetaminophen (N-acetyl-para-aminophenol: APAP)-induced hepatotoxicity is a common toxicity that is associated with oxidat...
Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials
Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials
Novel treatments that act beyond the conventionally targeted monoamine system are urgently needed to provide more effectiv...
3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
Studies on the assessment of anticancer efficacy of plant-derived phytochemicals by targeting signaling pathways have draw...
Marine peptides in lymphoma: surgery at molecular level for therapeutic understanding
Marine peptides in lymphoma: surgery at molecular level for therapeutic understanding
Lymphoma, the most common form of blood cancer, affects primarily the intricate network of tissues and organs known as the...
Role of platelets and NETs in arterial thrombosis
Role of platelets and NETs in arterial thrombosis
Arterial thrombosis is one of the main causes of mortality and mortality worldwide. Platelets are effectively targeted by ...
Evaluation of the iodoacetic acid effects on adipose-derived mesenchymal stem cells and alteration of their osteogenic differentiation potential by inducing oxidative stress
Evaluation of the iodoacetic acid effects on adipose-derived mesenchymal stem cells and alteration of their osteogenic differentiation potential by inducing oxidative stress
Drinking water disinfection byproducts (DBPs) can adversely affect human health. Iodoacetic acid (IAA) is a DBP associated...
The role of resveratrol in delivering antioxidant, anti-inflammatory, and anti-apoptotic defense against nephrotoxicity generated by titanium dioxide
The role of resveratrol in delivering antioxidant, anti-inflammatory, and anti-apoptotic defense against nephrotoxicity generated by titanium dioxide
Titanium dioxide is a prevalent food ingredient for human ingestion. We investigated the nephrotoxic effects of titanium d...
Evidence-based investigation of the efficacy and safety of venetoclax-containing regimens versus chemoimmunotherapy in chronic lymphocytic leukemia
Evidence-based investigation of the efficacy and safety of venetoclax-containing regimens versus chemoimmunotherapy in chronic lymphocytic leukemia
Randomized controlled trials (RCTs) comparing the treatment outcomes and adverse events of venetoclax-containing regimens ...
Identification and potential mechanism of a novel gastric cancer suppressor tRF-24-6VR8K09LE9
Identification and potential mechanism of a novel gastric cancer suppressor tRF-24-6VR8K09LE9
One of the most common gastrointestinal tumors is gastric cancer (GC), which has a high lethality and a poor prognosis. Re...
Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells
Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells
Breast cancer is the most common malignant tumor in women. Among its subtypes, triple-negative breast cancer (TNBC) is mor...
Impact of lisinopril on cisplatin-induced inflammation, oxidative stress, apoptosis, and impaired steroidogenesis in rat testis: involvement of Nrf2/Keap1/HO-1 and PPARγ signaling
Impact of lisinopril on cisplatin-induced inflammation, oxidative stress, apoptosis, and impaired steroidogenesis in rat testis: involvement of Nrf2/Keap1/HO-1 and PPARγ signaling
Testicular dysfunction is a significant long-term side effect of the chemotherapeutic drug cisplatin (CDDP), primarily due...
Exploring anticancer potential of betanin in DMBA-induced oral squamous cell carcinoma: an in silico and experimental study
Exploring anticancer potential of betanin in DMBA-induced oral squamous cell carcinoma: an in silico and experimental study
In addition to being able to fight cancer, betanin (BTN) has amazing natural antioxidant and peroxy-radical scavenging pro...
Novel insights into bexarotene's role in preventing cholestasis: mechanisms and implications
Novel insights into bexarotene's role in preventing cholestasis: mechanisms and implications
Cholestasis is defined as an impairment in the flow of bile, resulting in the accumulation of its components. Despite urso...
The potential of curcumin in mitigating acetaminophen-induced liver damage
The potential of curcumin in mitigating acetaminophen-induced liver damage
Acetaminophen (APAP) is a widely used over-the-counter medication for pain and fever, but its overuse can lead to liver to...
Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses
Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses
The escalating global burden of cardiovascular diseases is a growing concern. Numerous research studies have established t...
Cardioprotective effects of GPER agonist in ovariectomized diabetic rats: reversing ER stress and structural changes
Cardioprotective effects of GPER agonist in ovariectomized diabetic rats: reversing ER stress and structural changes
The incidence of diabetic cardiomyopathy (DCM) significantly increases in postmenopausal women, suggesting protective role...
Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis
Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis
New methods are essential to characterize the performance of substitute procedures for detecting therapeutic action(s) of ...
Cimifugin improves intestinal barrier dysfunction by upregulating SIRT1 to regulate the NRF2/HO-1 signaling pathway
Cimifugin improves intestinal barrier dysfunction by upregulating SIRT1 to regulate the NRF2/HO-1 signaling pathway
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal dysfunction. Cimifugin is an active component of Radix sapo...
Behavioural and neurochemical alterations following acute inflammation induced by intraperitoneal and intratracheal injection with lipopolysaccharide in mice
Behavioural and neurochemical alterations following acute inflammation induced by intraperitoneal and intratracheal injection with lipopolysaccharide in mice
The persistent symptoms of anxiety, depression, and fatigue that follow severe acute respiratory syndrome coronavirus 2 in...
Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence
Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence
Previous research from our group revealed a strong association between daily defined dose (DDD)-costs and -prescriptions o...
Insufficient correctness of package inserts for psychotropic drugs in Germany
Insufficient correctness of package inserts for psychotropic drugs in Germany
Package inserts often cause displeasure among patients as they are perceived as misleading and confusing. The aim of this ...
A comprehensive review on physiological and biological activities of carnosine: turning from preclinical facts to potential clinical applications
A comprehensive review on physiological and biological activities of carnosine: turning from preclinical facts to potential clinical applications
Carnosine, a compound with plethora of benefits, was originally discovered in 1900 and is formed by the amide linkage of &...
Potential promising of synthetic lethality in cancer research and treatment
Potential promising of synthetic lethality in cancer research and treatment
Cancer is a complex disease driven by multiple genetic changes, including mutations in oncogenes, tumor suppressor genes, ...
Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review
Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review
Resveratrol (RV—3, 5, 4′‐trihydroxystilbene) is a natural compound found in plants like red grapes, berr...
The effects of self-assembling peptide on glial cell activation
The effects of self-assembling peptide on glial cell activation
Glial cells play a critical role in the healthy and diseased phases of the central nervous system (CNS). CNS diseases invo...
Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation
Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation
Slow transit constipation (STC) seriously affects the physical and mental health of patients. While the active ingredients...
Knockdown of SIGLEC1 inhibits osteogenic differentiation to alleviate ankylosing spondylitis progression by suppressing the TGF-β1/SMAD signaling pathway
Knockdown of SIGLEC1 inhibits osteogenic differentiation to alleviate ankylosing spondylitis progression by suppressing the TGF-β1/SMAD signaling pathway
Ankylosing spondylitis (AS) is a chronic inflammatory joint disease, which can result in disability in severe cases and en...
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