Azizian H, Farhadi Z, Khaksari M (2022) Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats. Horm Mol Biol Clin Investig 43(4):427–436

Article  CAS  PubMed  Google Scholar 

Azizian H, Farhadi Z, Bader M, Alizadeh Ghalenoei J, Ghafari MA, Mahmoodzadeh S (2023) GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats. PLoS ONE 18(12):e0293630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balderas-Villalobos J, Molina-Muñoz T, Mailloux-Salinas P, Bravo G, Carvajal K, Gómez-Viquez NL (2013) Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome. Am J Physiol Heart Circ Physiol 305(9):H1344–H1353

Article  CAS  PubMed  Google Scholar 

Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ (2006) Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol 48(8):1688–1697

Article  CAS  PubMed  Google Scholar 

Chen J, Liu Y, Pan D, Xu T, Luo Y, Wu W, Wu P, Zhu H, Li D (2022) Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a. Cell Commun Signal 20(1):1–16

Article  Google Scholar 

De Francesco EM, Rocca C, Scavello F, Amelio D, Pasqua T, Rigiracciolo DC, Scarpelli A, Avino S, Cirillo F, Amodio N (2017) Protective role of GPER agonist G-1 on cardiotoxicity induced by doxorubicin. J Cell Physiol 232(7):1640–1649

Article  PubMed  Google Scholar 

Dearing C, Handa RJ, Myers B (2022) Sex differences in autonomic responses to stress: implications for cardiometabolic physiology. Am J Physiol Endocrinol Metab 323(3):E281–E289

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eguchi K, Boden-Albala B, Jin Z, Rundek T, Sacco RL, Homma S, Di Tullio MR (2008) Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic population. Am J Cardiol 101(12):1787–1791

Article  PubMed  PubMed Central  Google Scholar 

Fredersdorf S, Thumann C, Zimmermann WH, Vetter R, Graf T, Luchner A, Riegger GA, Schunkert H, Eschenhagen T, Weil J (2012) Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: in vivo and in vitro data. Cardiovasc Diabetol 11:1–11

Article  Google Scholar 

Gao F, Ma X, Ostmann AB, Das SK (2011) GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals. Endocrinology 152(4):1434–1447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzalez E, Broselid S, Kahn R, Olde B, Leeb-Lundberg F (2017) G protein-coupled estrogen receptor 1 (GPER1)/GPR30 Increases ERK1/2 activity through PDZ-dependent and-independent mechanisms. J Biol Chem 292(24):9932–9943

Article  Google Scholar 

Han Z-W, Chang Y-C, Zhou Y, Zhang H, Chen L, Zhang Y, Si J-Q, Li L (2019) GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury. Neural Regen Res 14(7):1221

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holmes A, Coppey L J, Davidson E P, Yorek M A (2015) Rat models of diet-induced obesity and high fat/low dose streptozotocin type 2 diabetes: effect of reversal of high fat diet compared to treatment with enalapril or menhaden oil on glucose utilization and neuropathic endpoints. J Diabetes Res 2015

Huang D, Wang X, Zhu Y, Gong J, Liang J, Song Y, Zhang Y, Liu L, Wei C (2021) Bazi Bushen capsule alleviates post-menopausal atherosclerosis via GPER1-dependent anti-inflammatory and anti-apoptotic effects. Front Pharmacol 12:658998

Article  CAS  PubMed  PubMed Central  Google Scholar 

Irandoost P, Mesri Alamdari N, Saidpour A, Shidfar F, Farsi F, Asghari Jafarabadi M, Alivand MR, Vafa M (2020) The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats. BMC Res Notes 13(1):1–6

Article  Google Scholar 

Jafarynezhad F, Shahbazian M, Farhadi Z, Yadeghari M, Rezvani M E, Safari F, Azizian H (2022) The G-protein-coupled estrogen receptor agonist prevents cardiac lipid accumulation by stimulating cardiac peroxisome proliferator-activated receptor α: a preclinical study in ovariectomized-diabetic rat model. Int J Endocrinol Metab 20(3). https://doi.org/10.5812/ijem-123560

Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L (2010) Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2. Lewis Rats Plos One 5(11):e15433

Article  CAS  PubMed  Google Scholar 

Jiao L, Machuki JOA, Wu Q, Shi M, Fu L, Adekunle AO, Tao X, Xu C, Hu X, Yin Z, Sun H (2020) Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases. Am J Physiol Heart Circ Physiol 318(4):H820–H829

Article  CAS  PubMed  Google Scholar 

Kang S, Dahl R, Hsieh W, Shin A, Zsebo KM, Buettner C, Hajjar RJ, Lebeche D (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J Biol Chem 291(10):5185–5198

Article  CAS  PubMed  Google Scholar 

Kimura T, Kagami K, Sato A, Osaki A, Ito K, Horii S, Toya T, Masaki N, Yasuda R, Nagatomo Y (2022) Sarco/endoplasmic reticulum Ca2+ ATPase 2 activator ameliorates endothelial dysfunction; insulin resistance in diabetic mice. Cells 11(9):1488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kooptiwut S, Mahawong P, Hanchang W, Semprasert N, Kaewin S, Limjindaporn T, Yenchitsomanus P-T (2014) Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell death. J Steroid Biochem Mol Biol 139:25–32

Article  CAS  PubMed  Google Scholar 

Lee TM, Lin SZ, Chang NC (2014) Both GPER and membrane oestrogen receptor-α activation protect ventricular remodelling in 17β oestradiol-treated ovariectomized infarcted rats. J Cell Mol Med 18(12):2454–2465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Zhang T, Dai H, Liu G, Wang H, Sun Y, Zhang Y, Ge Z (2007) Involvement of endoplasmic reticulum stress in myocardial apoptosis of streptozocin-induced diabetic rats. J Clin Biochem Nutr 41(1):58–67

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Cheng L, Liang H, Duan W, Hu J, Zhi W, Yang J, Liu Z, Zhao M, Liu J (2016) GPER inhibits diabetes-mediated RhoA activation to prevent vascular endothelial dysfunction. Eur J Cell Biol 95(2):100–113

Article  CAS  PubMed  Google Scholar 

Li R, Wang Y, Chen P, Meng J, Zhang H (2020) G-protein coupled estrogen receptor activation protects the viability of hyperoxia-treated primary murine retinal microglia by reducing ER stress. Aging (Albany NY) 12(17):17367

Article  CAS  PubMed  Google Scholar 

Ma S, Feng J, Zhang R, Chen J, Han D, Li X, Yang B, Li X, Fan M, Li C (2017) SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice. Oxid Med Cell Longev 2017. https://doi.org/10.1155/2017/4602715

Martensson UE, Salehi SA, Windahl S, Gomez MF, SwäRd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, GräNde P-O (2009) Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology 150(2):687–698

Article  PubMed  Google Scholar 

Murarka S, Movahed MR (2010) Diabetic cardiomyopathy. J Card Fail 16(12):971–979

Article  PubMed  Google Scholar 

Ng YH, Lamberts RR, Jones PP, Sammut IA, Diffee GM, Wilkins GT, Baldi JC (2022) Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart. Sci Rep 12(1):16904

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nurullin L, Tyapkina O, Volkov E (2016) Fluorescent microscopy identification of the expression of a2 and b1 NA+/K+-ATPase, a1S (L-TYPE), ÑÀ2+-channel, serca 1/2/3 CA2+-ATPase subunits at fast and slow muscles in the hypogravity modeling experiments in rats. Tsitologiia 58(6):444–450

CAS  PubMed  Google Scholar 

Oza MJ, Kulkarni YA (2020) Formononetin alleviates diabetic cardiomyopathy by inhibiting oxidative stress and upregulating SIRT1 in rats. Asian Pac J Trop Biomed 10(6):254–262

Article  CAS  Google Scholar 

Park SW, Zhou Y, Lee J, Lee J, Ozcan U (2010) Sarco (endo) plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc Natl Acad Sci U S A 107(45):19320–19325

Article