Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells

Bai X, Ni J, Beretov J et al (2018) Cancer stem cell in breast cancer therapeutic resistance. Cancer Treat Rev 69:152–163. https://doi.org/10.1016/j.ctrv.2018.07.004

Article  CAS  PubMed  Google Scholar 

Battaglia AM, Chirillo R, Aversa I et al (2020) Ferroptosis and cancer: mitochondria meet the “Iron Maiden” cell death. Cells 9:1505. https://doi.org/10.3390/cells9061505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229–263. https://doi.org/10.3322/caac.21834

Article  PubMed  Google Scholar 

Cao W, Hu C, Wu L et al (2016) Rosmarinic acid inhibits inflammation and angiogenesis of hepatocellular carcinoma by suppression of NF-κB signaling in H22 tumor-bearing mice. J Pharmacol Sci 132:131–137. https://doi.org/10.1016/j.jphs.2016.09.003

Article  CAS  PubMed  Google Scholar 

Chang L-C, Chiang S-K, Chen S-E et al (2018) Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis. Cancer Lett 416:124–137. https://doi.org/10.1016/j.canlet.2017.12.025

Article  CAS  PubMed  Google Scholar 

Chen Y, Yang X, Li H et al (2024) Self-assembled fe-phenolic acid network synergizes with ferroptosis to enhance tumor nanotherapy. Small 20:e2402073. https://doi.org/10.1002/smll.202402073

Article  CAS  PubMed  Google Scholar 

Chu M, An X, Fu C et al (2023) Disulfiram/copper induce ferroptosis in triple-negative breast cancer cell line MDA-MB-231. FBL 28:186. https://doi.org/10.31083/j.fbl2808186

Article  CAS  PubMed  Google Scholar 

Consoli V, Sorrenti V, Pittalà V et al (2022) Heme oxygenase modulation drives ferroptosis in TNBC cells. Int J Mol Sci 23:5709. https://doi.org/10.3390/ijms23105709

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding Y, Chen X, Liu C et al (2021) Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. J Hematol Oncol 14:19. https://doi.org/10.1186/s13045-020-01016-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du J, Wang L, Huang X et al (2021) Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. Phytomedicine 85:153551. https://doi.org/10.1016/j.phymed.2021.153551

Article  CAS  PubMed  Google Scholar 

Gan H, Huang X, Luo X et al (2023) A Mitochondria-targeted ferroptosis inducer activated by glutathione-responsive imaging and depletion for triple negative breast cancer theranostics. Adv Healthc Mater 12:e2300220. https://doi.org/10.1002/adhm.202300220

Article  CAS  PubMed  Google Scholar 

Garrido-Castro AC, Lin NU, Polyak K (2019) Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment. Cancer Discov 9:176–198. https://doi.org/10.1158/2159-8290.CD-18-1177

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassannia B, Vandenabeele P, Berghe TV (2019) Targeting ferroptosis to iron out cancer. Cancer Cell 35:830–849. https://doi.org/10.1016/j.ccell.2019.04.002

Article  CAS  PubMed  Google Scholar 

Huang Y, Cai Y, Huang R, Zheng X (2018) Rosmarinic acid combined with adriamycin induces apoptosis by triggering mitochondria-mediated signaling pathway in HepG2 and Bel-7402 cells. Med Sci Monit 24:7898–7908. https://doi.org/10.12659/MSM.910673

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang J-Y, Hsu T-W, Chen Y-R, Kao S-H (2024) Rosmarinic acid potentiates cytotoxicity of cisplatin against colorectal cancer cells by enhancing apoptotic and ferroptosis. Life (Basel) 14:1017. https://doi.org/10.3390/life14081017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khalafi A, Moradian F, Rafiei A (2020) Anticancer effect of bovine lactoferrin on breast cancer cell line MCF7 and the evaluation of bax and bak genes expression involved in apoptosis. Res Mol Med 8:107–116

Article  CAS  Google Scholar 

Kim C, Gao R, Sei E et al (2018) Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing. Cell 173:879-893.e13. https://doi.org/10.1016/j.cell.2018.03.041

Article  CAS  PubMed  PubMed Central  Google Scholar 

Konstantinou EK, Panagiotopoulos AA, Argyri K et al (2023) Molecular pathways of rosmarinic acid anticancer activity in triple-negative breast cancer cells: a literature review. Nutrients 16:2. https://doi.org/10.3390/nu16010002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhang H, Merkher Y et al (2022) Recent advances in therapeutic strategies for triple-negative breast cancer. J Hematol Oncol 15:121. https://doi.org/10.1186/s13045-022-01341-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, He D, Li S et al (2023) Ferroptosis: the emerging player in remodeling triple-negative breast cancer. Front Immunol 14:1284057. https://doi.org/10.3389/fimmu.2023.1284057

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahmoud MA, Okda TM, Omran GA, Abd-Alhaseeb MM (2021) Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation. J Appl Biomed 19:202–209. https://doi.org/10.32725/jab.2021.024

Article  PubMed  Google Scholar 

Maroufi NF, Rashidi M, Vahedian V et al (2022) Effect of Apatinib plus melatonin on vasculogenic mimicry formation by cancer stem cells from breast cancer cell line. Breast Cancer 29:260–273. https://doi.org/10.1007/s12282-021-01310-4

Article  PubMed  Google Scholar 

Mathew M, Sivaprakasam S, Dharmalingam-Nandagopal G et al (2024) Induction of oxidative stress and ferroptosis in triple-negative breast cancer cells by niclosamide via blockade of the function and expression of SLC38A5 and SLC7A11. Antioxidants (Basel) 13:291. https://doi.org/10.3390/antiox13030291

Article  CAS  PubMed  Google Scholar 

Messeha SS, Zarmouh NO, Asiri A, Soliman KFA (2020) Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. Eur J Pharmacol 885:173419. https://doi.org/10.1016/j.ejphar.2020.173419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moon D-O, Kim M-O, Lee J-D et al (2010) Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells. Cancer Lett 288:183–191. https://doi.org/10.1016/j.canlet.2009.06.033

Article  CAS  PubMed  Google Scholar 

Neitemeier S, Jelinek A, Laino V et al (2017) BID links ferroptosis to mitochondrial cell death pathways. Redox Biol 12:558–570. https://doi.org/10.1016/j.redox.2017.03.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pouremamali F, Vahedian V, Hassani N et al (2022) The role of SOX family in cancer stem cell maintenance: With a focus on SOX2. Pathol Res Pract 231:153783. https://doi.org/10.1016/j.prp.2022.153783

Article  CAS  PubMed  Google Scholar 

Wang Y, Pang X, Liu Y et al (2023) SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy res

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