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Toll-like receptor 9 contributes to perivascular adipose tissue dysfunction in spontaneously hypertensive rats
Arterial hypertension is a persistent global health issue increasingly identified as a low-grade chronic inflammatory cond...
Alectinib causes sinus bradycardia by suppressing L-type calcium current in sinus node
Alectinib is a highly selective tyrosine kinase inhibitor (TKI). It has been approved by over 80 countries for the current...
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells
Liver fibrosis, characterized by excessive accumulation of extracellular matrix proteins, represents a critical pathologic...
Relaxing effect of ramelteon on the uterus of non-pregnant and pregnant rats: Importance of melatonin receptors and BKCa
Melatonin is produced and released by pineal gland into the bloodstream in response to a hypothalamic circadian clock. All...
Melatonin induces urethral contraction and increases intraurethral pressure via MT1 receptor activation in female rats
The hormone melatonin is primarily produced by the pineal gland and released into blood circulation during the dark period...
Nicotinic acid increases adipose tissue dietary fatty acid trapping and reduces postprandial hepatic and cardiac fatty acid uptake in prediabetes
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Cath-HG exhibits anti-acne activities via multiple mechanisms
Acne vulgaris is one of the most prevalent dermatological conditions worldwide, which is characterized by androgen-induced...
Erythromycin repurposing for hepatocellular carcinoma treatment: Targeting CD24 to enhance anti-tumor immunity
Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers and is the third leading cause of cancer-related ...
Evolocumab ameliorates myocardial fibrosis and improves metabolic syndrome–induced cardiac dysfunction in rats via inhibiting PCSK9/NLRP3 inflammasome and Caspase-1 / IL-1β pathways
Metabolic syndrome (syndrome X, MetS) is a multifactorial disease with multiple risk factors that arises from insulin resi...
Impact of sodium butyrate on stroke-related intestinal injury in diabetic mice: Interference with Caspase-1/GSDMD pyroptosis pathway and preservation of intestinal barrier
Stroke remains a significant global health challenge, causing 93.8 million prevalent cases and 11.9 million incident strok...
Chlorogenic acid alleviates DNCB-induced atopic dermatitis by inhibiting the Akt1/NF-κB signaling pathway
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by erythema, dryness, swelling, and persistent...
To explore the potential combined treatment strategy for colorectal cancer: Inhibition of cancer stem cells and enhancement of intestinal immune microenvironment
Traditional treatments for colorectal cancer (CRC), such as surgery, radiotherapy and chemotherapy, are unsatisfactory due...
Steroid constituents of Solidago canadensis alleviate LPS-induced inflammation via AMPK regulated mitophagy/NLRP3 and NF-κB pathway
Inflammation is a protective mechanism of the host in response to infection and cellular danger signals(Gilroy, 2021). How...
Evaluating spironolactone monotherapy against combined treatment with metformin in rat PCOS model
Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic cum endocrine dysfunction (Norman et al., 2007). PCOS i...
Timosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue
Metabolic syndrome (MetS) is a globally prevalent comprehensive disease characterized by obesity, hypertension, hyperglyce...
Plasma esketamine and noresketamine levels and antidepressant response with oral esketamine treatment
ObjectiveOral esketamine has relatively low and variable bioavailability, which may complicate broader use as an antidepre...
Pharmacokinetics of oxycodone in rats: Influence of micronized magnesium lactate on oxycodone bioavailability
Medicine is a constantly evolving field where technological and research advancements bring revolutionary changes to the d...
AI in action: Changes to student perceptions when using generative artificial intelligence for the creation of a multimedia project-based assessment
IntroductionNew modes of assessments are needed to evaluate of the authenticity of student learning in an artificial intel...
Rutin protects the pancreas from inflammatory injury and oncogene-driven tumorigenesis by inhibiting acinar to ductal metaplasia
Pancreatic diseases are a typical representative of clinically difficult diseases. The rapid progression of acute pancreat...
New perspectives on the treatment of diabetic nephropathy: Challenges and prospects of mesenchymal stem cell therapy
Diabetic nephropathy (DN) is a renal microvascular lesion caused by diabetes and is also one of the main causes of end-sta...
TRPV1: A novel target for the therapy of diabetes and diabetic complications
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The NF-κB pathway: Key players in neurocognitive functions and related disorders
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Protein kinase C (PKC) inhibitor Calphostin C activates PKC in a light-dependent manner at high concentrations via the production of singlet oxygen
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Positive allosteric modulation of glutamate transporter reduces cocaine-induced locomotion and expression of cocaine conditioned place preference in rats
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Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice
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Stimulation of kappa opioid receptors in the nucleus accumbens promotes feeding behavior in mice: Acute restoration of feeding during anorexia induced by 5-fluorouracil
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Regulation of hippocampal miRNA expression by intestinal flora in anxiety-like mice
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Rhoifolin, baicalein 5,6-dimethyl ether and agathisflavone prevent amnesia induced in scopolamine zebrafish (Danio rerio) model by increasing the mRNA expression of bdnf, npy, egr-1, nfr2α, and creb1 genes
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Sonic hedgehog signaling facilitates pyroptosis in mouse heart following ischemia/reperfusion via enhancing the formation of CARD10-BCL10-MALT1 complex
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Small-molecule mediated MuRF1 inhibition protects from doxorubicin-induced cardiac atrophy and contractile dysfunction
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