×
Close
Sign Up
Login
Home
Library S
Library D
Events & Partner
WeMed
MDLA Events Platform
Events
Media Partners
Educational Partner
User Tools
FAQ/USER GUIDE
Language
English
中文/ Chinese
French
Português
Español
Arabic
Russian
Contact Us
×
Close
mdla_1
mdla_2
mdla_3
mdla_4
mdla_5
mdla_6
Categories
Pharmacology & Pharmacy
35311
Global Medical University
5169
Allergy
1797
Anatomy & Morphology
1584
Andrology
379
Anesthesia & Intensive Care
1282
Anesthesiology
5456
Audiology & Speech-Language Pathology
347
Behavioral Sciences
100
Biochemical Research Methods
7129
Biochemistry & Molecular Biology
29964
Biodiversity Conservation
345
Biology
8446
Biophysics
8229
Biotechnology & Applied Microbiology
8602
Cardiac & Cardiovascular Systems
31023
Cardiovascular & Respiratory Systems
1381
Cell & Tissue Engineering
696
Cell Biology
11195
Chemistry, Analytical
4293
Chemistry, Applied
10903
Chemistry, Medicinal
8728
Chemistry, Multidisciplinary
18516
Clinical Immunology & Infectious Disease
454
Clinical Medicine
8949
Clinical Neurology
16596
Clinical Psychology & Psychiatry
1309
Critical Care Medicine
3193
Dentistry, Oral Surgery & Medicine
13492
Dermatology
7467
Developmental Biology
6899
Ecology
643
Education, Scientific Disciplines
2067
Emergency Medicine
4081
Endocrinology, Metabolism & Nutrition
24452
Engineering, Biomedical
3750
Entomology
450
Environmental Medicine & Public Health
4715
Evolutionary Biology
268
Gastroenterology & Hepatology
12194
General & Internal Medicine
6958
Genetics & Heredity
15063
Geriatrics & Gerontology
5126
Gerontology
369
Health Care Sciences & Services
16177
Health Policy & Services
649
Hematology
5598
Immunology
24695
Infectious Diseases
13982
Integrative & Complementary Medicine
2934
Medical Ethics
1230
Medical Informatics
2270
Medical Laboratory Technology
419
Medicine, General & Internal
44236
Medicine, Legal
532
Medicine, Research & Experimental
17733
Microbiology
23270
Mycology
0
Nanoscience & Nanotechnology
5454
Neuroimaging
1395
Neurology
4546
Neurosciences
39652
Nursing
9694
Nutrition & Dietetics
7854
Obstetrics & Gynecology
8286
Oncology
52188
Ophthalmology
9705
Optics
4283
Orthopedics
11773
Orthopedics, Rehabilitation & Sports Medicine
1799
Otolaryngology
1590
Otorhinolaryngology
4862
Parasitology
1138
Pathology
5141
Pediatrics
21657
Peripheral Vascular Disease
4823
Pharmacology/Toxicology
12080
Physiology
8870
Polymer Science
533
Primary Health Care
870
Psychiatry
19047
Psychology
5209
Psychology, Applied
112
Psychology, Biological
388
Psychology, Clinical
811
Psychology, Developmental
244
Psychology, Educational
169
Psychology, Experimental
166
Psychology, Mathematical
0
Psychology, Multidisciplinary
1688
Psychology, Psychoanalysis
30
Psychology, Social
119
Public Health & Health Care Science
2246
Public, Environmental & Occupational Health
27064
Quantum Science & Technology
0
Radiology, Nuclear Medicine & Imaging
12394
Radiology, Nuclear Medicine & Medical Imaging
8088
Rehabilitation
3048
Remote Sensing
0
Reproductive Biology
2852
Reproductive Medicine
1196
Research/Laboratory Medicine & Medical Technology
3967
Respiratory System
7406
Rheumatology
6039
Social Sciences, Biomedical
1196
Substance Abuse
2751
Surgery
33760
Toxicology
4445
Transplantation
948
Tropical Medicine
300
Urology & Nephrology
13014
Veterinary Sciences
35
Virology
2501
Zoology
0
Channels
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
180
Medrxiv - Pharmacology and Therapeutics
257
AAPS JOURNAL
326
ACTA PHARMACOLOGICA SINICA
520
ADVANCED DRUG DELIVERY REVIEWS
0
ANTIVIRAL RESEARCH
0
CANCER CHEMOTHERAPY AND PHARMACOLOGY
379
CHEMICO-BIOLOGICAL INTERACTIONS
936
CHEMMEDCHEM
258
CLINICAL PHARMACOKINETICS
338
CLINICAL PHARMACOLOGY & THERAPEUTICS
239
CNS DRUGS
233
CNS NEUROSCIENCE & THERAPEUTICS
107
DRUG DISCOVERY TODAY
263
DRUG METABOLISM AND DISPOSITION
399
DRUG RESISTANCE UPDATES
207
DRUG SAFETY
323
DRUGS
478
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
708
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
637
EUROPEAN JOURNAL OF PHARMACOLOGY
1442
INTERNATIONAL IMMUNOPHARMACOLOGY
2738
INTERNATIONAL JOURNAL OF PHARMACEUTICS
1946
JOURNAL OF CONTROLLED RELEASE
1312
JOURNAL OF ETHNOPHARMACOLOGY
2270
JOURNAL OF FOOD AND DRUG ANALYSIS
181
JOURNAL OF PHARMACEUTICAL ANALYSIS
427
NATURE REVIEWS DRUG DISCOVERY
604
NEUROPHARMACOLOGY
0
NEUROPSYCHOPHARMACOLOGY
713
NEUROTOXICOLOGY
0
PHARMACOGENOMICS
11
PHARMACOLOGY & THERAPEUTICS
370
PHARMACOTHERAPY
54
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
82
TOXICOLOGY AND APPLIED PHARMACOLOGY
0
TOXICOLOGY IN VITRO
477
VALUE IN HEALTH
20
VASCULAR PHARMACOLOGY
0
ANNALS OF PHARMACOTHERAPY
110
ANTIBIOTICS-BASEL
1968
BIOMEDICAL CHROMATOGRAPHY
222
BIOPHARMACEUTICS & DRUG DISPOSITION
16
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
0
CHEMOTHERAPY
77
CHINESE MEDICINE
406
CHIRALITY
70
CLINICAL NEUROPHARMACOLOGY
50
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
111
CLINICAL THERAPEUTICS
52
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
46
DOSE-RESPONSE
68
DRUG DEVELOPMENT RESEARCH
102
EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE
302
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
707
HUMAN & EXPERIMENTAL TOXICOLOGY
105
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
0
INTERNATIONAL JOURNAL OF TOXICOLOGY
36
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
172
JOURNAL OF ANTIBIOTICS
280
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
375
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
30
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
170
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
1846
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
505
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
176
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
0
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
0
JOURNAL OF PHARMACOLOGICAL SCIENCES
0
JOURNAL OF PHARMACY AND PHARMACOLOGY
18
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
559
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
121
PHARMACOGENOMICS & PERSONALIZED MEDICINE
325
PHARMACOLOGY
124
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
0
SKIN PHARMACOLOGY AND PHYSIOLOGY
69
THERAPEUTIC ADVANCES IN DRUG SAFETY
22
THERAPEUTIC DRUG MONITORING
158
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
50
INDIAN JOURNAL OF PHARMACOLOGY
16
JOURNAL OF APPLIED BIOMEDICINE
44
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
47
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
354
THERAPIE
374
SCIENTIA PHARMACEUTICA
97
ADMET AND DMPK
111
ADVANCED THERAPEUTICS
83
ADVANCES IN PHARMACOLOGY AND PHARMACY
135
ADVANCES IN TRADITIONAL MEDICINE
34
ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE
26
ASIAN JOURNAL OF PHARMACEUTICS
166
CANADIAN JOURNAL OF HOSPITAL PHARMACY
192
CURRENT DRUG THERAPY
20
EGYPTIAN PHARMACEUTICAL JOURNAL
42
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
272
GABI JOURNAL-GENERICS AND BIOSIMILARS INITIATIVE JOURNAL
62
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
212
JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH
164
JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY
29
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
130
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
287
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS
53
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
39
JOURNAL OF PHARMACY PRACTICE
78
JOURNAL OF RESEARCH IN PHARMACY PRACTICE
40
RESEARCH JOURNAL OF PHARMACOGNOSY
98
PHARMACEUTICAL MEDICINE
63
PHARMACIA
140
PHARMACOECONOMICS-OPEN
276
PHARMACY
176
PHARMACY PRACTICE-GRANADA
31
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
136
DRUGS & AGING
282
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
492
INVESTIGATIONAL NEW DRUGS
357
JOURNAL OF PHARMACEUTICAL INNOVATION
376
NEUROTHERAPEUTICS
355
PEDIATRIC DRUGS
204
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
335
SCI Abstract
search
ALL
RECOMMENDED
+
Semi-mechanistic population pharmacokinetic modeling of DZIF-10c, a neutralizing antibody against SARS-Cov-2: predicting systemic and lung exposure following inhaled and intravenous administration
DZIF-10c (BI 767551) is a recombinant human monoclonal antibody of the IgG1 kappa isotype. It acts as a SARS-CoV-2 neutral...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Model-informed approach to estimate treatment effect in placebo-controlled clinical trials using an artificial intelligence-based propensity weighting methodology to account for non-specific responses to treatment
In randomized, placebo controlled clinical trials (RCT) in major depressive disorders (MDD), treatment response (TR) is es...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Comparison of the power and type 1 error of total score models for drug effect detection in clinical trials
Composite scale data consists of numerous categorical questions/items that are often summed as a total score and are commo...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
A PopPBPK-RL approach for precision dosing of benazepril in renal impaired patients
Current treatment recommendations mainly rely on rule-based protocols defined from evidence-based clinical guidelines, whi...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
QSP modeling of a transiently inactivating antibody-drug conjugate highlights benefit of short antibody half life
Antibody drug conjugates (ADC) are a promising class of oncology therapeutics consisting of an antibody conjugated to a pa...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Novel endpoints based on tumor size ratio to support early clinical decision-making in oncology drug-development
In oncology drug development, overall response rate (ORR) is commonly used as an early endpoint to assess the clinical ben...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Translational pharmacokinetic and pharmacodynamic modelling of the anti-ADAMTS-5 NANOBODY (M6495) using the neo-epitope ARGS as a biomarker
M6495 is a first-in-class NANOBODY® molecule and an inhibitor of ADAMTS-5, with the potential to be a disease modifyi...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Application of model-informed drug development (MIDD) for dose selection in regulatory submissions for drug approval in Japan
Model-informed drug development (MIDD) is an approach to improve the efficiency of drug development. To promote awareness ...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?
P-glycoprotein (P-gp) is a key efflux transporter and may be involved in drug-drug interactions (DDIs) at the blood-brain ...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
A physiologically-based quantitative systems pharmacology model for mechanistic understanding of the response to alogliptin and its application in patients with renal impairment
Alogliptin is a highly selective inhibitor of dipeptidyl peptidase-4 and primarily excreted as unchanged drug in the urine...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
No QT interval prolongation effect of sepiapterin: a concentration-QTc analysis of pooled data from phase 1 and phase 3 studies in healthy volunteers and patients with phenylketonuria
Sepiapterin is an exogenously synthesized new chemical entity that is structurally equivalent to endogenous sepiapterin, a...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Stronger together: a cross-SIG perspective on improving drug development
Pharmacometric modeling and simulation (M&S) plays an increasingly important role in drug development. In order to bri...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Quantifying natural amyloid plaque accumulation in the continuum of Alzheimer’s disease using ADNI
Brain amyloid beta neuritic plaque accumulation is associated with an increased risk of progression to Alzheimer’s d...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?
Plasma pharmacokinetic (PK) profiles often do not resemble the PK within the central nervous system (CNS) because of blood...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Defining preclinical efficacy with the DNAPK inhibitor AZD7648 in combination with olaparib: a minimal systems pharmacokinetic–pharmacodynamic model
AZD7648 is a potent inhibitor of DNA-dependent protein kinase (DNA-PK), which is part of the non-homologous end-joining DN...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
The impact of misspecified covariate models on inclusion and omission bias when using fixed effects and full random effects models
Identification of covariates that can explain sources of variability among individuals in pharmacometric models is key, as...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Sampling from covariate distribution may not always be necessary in PK/PD simulations: illustrative examples with antibiotics
Pharmacokinetics (PK)/pharmacodynamics (PD) modeling and simulation is crucial for optimizing antimicrobial dosing. This s...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Imputation of missing clock times – application to procalcitonin concentration time course after birth
The time course of biomarkers (e.g., acute phase proteins) are typically described using days relative to events of intere...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Information-theoretic evaluation of covariate distributions models
Statistical modelling of covariate distributions allows to generate virtual populations or to impute missing values in a c...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Advancing inclusive healthcare through PBPK modelling: predicting the impact of CYP genotypes and enzyme ontogenies on infant exposures of venlafaxine and its active metabolite O-desmethylvenlafaxine in lactation
About 15–20% of women experience postnatal depression and may seek advice about medication use whilst breastfeeding....
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Predicting efficacy assessment of combined treatment of radiotherapy and nivolumab for NSCLC patients through virtual clinical trials using QSP modeling
Non-Small Cell Lung Cancer (NSCLC) remains one of the main causes of cancer death worldwide. In the urge of finding an eff...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
On inductive biases for the robust and interpretable prediction of drug concentrations using deep compartment models
Conventional pharmacokinetic (PK) models contain several useful inductive biases guiding model convergence to more realist...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Note on importance of correct stoichiometric assumptions for modeling of monoclonal antibodies
Pharmacokinetic modeling of monoclonal antibodies (mAbs) with non-linear binding is based on equations of the target-media...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Oral docetaxel plus encequidar – A pharmacokinetic model and evaluation against IV docetaxel
The development of optimized dosing regimens plays a crucial role in oncology drug development. This study focused on the ...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson’s disease
The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apom...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
General quasi-equilibrium multivalent binding model to study diverse and complex drug-receptor interactions of biologics
Pharmacokinetics and pharmacodynamics of many biologics are influenced by their complex binding to biological receptors. B...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Visual predictive check of longitudinal models and dropout
Visual predictive checks (VPC) are commonly used to evaluate pharmacometrics models. However their performance may be hamp...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
A review of the physiological effects of microgravity and innovative formulation for space travelers
During the space travel mission, astronauts’ physiological and psychological behavior will alter, and they will star...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Generative models for synthetic data generation: application to pharmacokinetic/pharmacodynamic data
The generation of synthetic patient data that reflect the statistical properties of real data plays a fundamental role in ...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Population pharmacokinetics and exposure–response relationships of maribavir in transplant recipients with cytomegalovirus infection
Maribavir is approved for management of post-transplant cytomegalovirus (CMV) infections refractory and/or resistant to CM...
Journal Of Pharmacokinetics And Pharmacodynamics
comment
0
thumb_up
0
Load More
Modal title
×
Modal title
×
Share
Login
Global News and Health Forum
Join Now!
Member Login
Remember me
Forgot password?
Or using
Linkedin