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Picoliter ice particles by supersonic cryogenic jets for transdermal drug delivery: Extracellular vesicle application for skin diseases
The data supporting the results in this study are available within the paper and its Supplementary Information. The raw an...
Raman spectroscopy as a tool to accelerate development of complex medicinal products
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Targeting HMGB1 modulates cancer-associated fibroblasts and enhances radiotherapy in lung adenocarcinoma
Lung cancer is the second most common cancer in the world and has the highest mortality rate [1,2]. NSCLC represents appro...
Photochemical internalization with verteporfin-liposomes enhances oxaliplatin retention and efficacy in models of pancreatic cancer
Resistance to chemotherapy remains a significant challenge for the treatment of pancreatic cancer. In addition to conventi...
Antibacterial hyaluronic acid hydrogel with sustained release of larazotide as effective colitis treatment
The gastrointestinal tract is extensively colonized by a diverse microbial community. Composed of the mucus layer, gut mic...
Computation-aided design of rod-shaped nanoparticles for tumoral targeting
Significant challenges remain in drug delivery, particularly in targeting hard-to-reach tissues such as solid tumors, whic...
Outer membrane vesicle–coated ferrocene nanoparticles induce dual ferroptosis for cancer immunotherapy
Bacteria are found as integral component of numerous kinds of cancer, including colorectal, pancreatic, lung, and breast c...
Injectable PROTAC-loaded hydrogel remodels the tumor microenvironment to potentiate radio-immunotherapy
Cancer has become one of the world's major health problems, posing a serious threat to human life and causing widespread c...
Fluorescent Probes Targeting Acyl-CoA Synthetase Long-Chain Family Member 4 for Intraoperative Imaging of Hepatocellular Carcinoma
PurposeThis study aims to develop and validate a novel ACSL4-targeted fluorescent probe to enhance intraoperative visualiz...
Understanding the kinetics of macrophage uptake and the metabolic fate of iron-carbohydrate complexes used for iron deficiency anemia treatment
Iron-carbohydrate complexes (ICCs) are widely used nanomedicines to treat iron deficiency anemia, yet their intracellular ...
Pulmonary delivery of small circular RNA vaccines for influenza prevention
Respiratory viral infection is associated with various diseases, such as influenza caused by seasonal influenza infection....
Immunomodulatory microbubbles targeting integrin αvβ3 in combination with immunotherapy for the theranostic of anaplastic thyroid cancer in mice
Thyroid cancer (TC) is the most common endocrine tumor, with a rapidly increasing incidence in recent years. Anaplastic th...
Lipid nanoparticle mediated delivery of dsDNA to the murine retina
Gene therapy has become a successful tool for treating inherited retinal diseases (IRDs). To date, recombinant adeno-assoc...
Novel TNF-α-targeting mRNA therapy for sustained psoriasis treatment and relapse prevention by suppressing IL-15-TRM signaling
Psoriasis is a chronic autoimmune skin disease driven by immune system dysregulation and is pathologically characterized b...
Corrigendum to “Poly(ethylene oxide)-modified poly(β-amino Ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery” [Journal of Controlled Release, 86 (2003) 223–234]
Volume 387, 10 November 2025, 114170Author links open overlay panelAnupama Potineni a, David M. Lynn b, Robert Langer b, M...
Polymeric-based neoantigen nanovaccine synergizes with PD-1/PD-L1 modulators, reprogramming the melanoma microenvironment
Programmed cell death protein 1 (PD-1) and its ligand PD-L1 are targets of immune checkpoint blockade (ICB) therapies that...
Nanotechnology-based approaches to tackle bacterial infections
Bacterial infections have emerged as a critical global health concern. More specifically, antibiotic resistant infections,...
DNA nanostructures with 1D, 2D and 3D for intelligent drug delivery
The rapid advancement of nanotechnology and its materials has provided powerful technical support for the innovation of mo...
Effects of nanoparticle physicochemical properties on macrophage polarization
According to the world health statistics 2024, cancer accounts for over 20 million new diagnoses annually and results in m...
Polymer-based chemo-immunotherapy: Combining immunogenic cell death induction and PD-L1 blockade enhances antitumor immunity in melanoma
Melanoma remains a challenging malignancy despite the significant outcomes achieved with immune checkpoint inhibitor (ICI)...
Fluorinated multifunctional polymer vesicles for enhanced ocular surface penetration and synergistic treatment of dry eye disease
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ROS-differentiated release of Apelin-13 from hydrogel comprehensively treats myocardial ischemia-reperfusion injury
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Gas-propelled anti-hair follicle aging microneedle patch for the treatment of androgenetic alopecia
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Biomimetic exosome harnessing exosomal lipidomics and functional proteins for PEDF-pDNA delivery in high altitude pulmonary edema intervention
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Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment
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Phase-separating Pt(IV)-graft-glycopeptides sequentially sensing pH and redox for deep tumor penetration and targeting chemotherapy
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In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes
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Harnessing the Potential of Human Breast Milk to Boost Intestinal Permeability for Nanoparticles and Macromolecules
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Smart core-shell microneedles for psoriasis therapy: In situ self-assembly of calcium ion-coordinated dexamethasone hydrogel
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Investigating the delivery of PD-L1-targeted immunoliposomes in a dynamic cervical cancer-on-a-chip model
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